MMSL 2001, 70(S1):33-34

PHARMACOKINETIC STUDIES ON THREE REACTIVATORS OF CHOLINESTERASE

T. K. Ivanov, Ch. D. Dishovski, E. I. Tzerovski, I. J. Petrova
Military Medical Academy, Laboratory of Experimental Toxicology, Bulgaria

The drug therapy on intoxication with organophosphoric compounds (OPC) included mainly combination of cholinesterase reactivators and cholinolytics (4). A variety 'Of bispyridinium mono- and dioximes have been synthesized over several years in order to improve the treatment of poisoning with highly toxic organophosphates. The “H” -oximes (HI-6 and HLo-7) synthesized by Prof. Hagedorn are the most popular now.
Some of the pyridine-heterocyclic oximes, synthesized in Military Medical Academy, Sofia have good protective effect against OPC intoxication. Very important is their anticonvulsive action (3)....

Keywords: Cholinesterase; toxicology

Published: December 2, 2001  Show citation

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Ivanov, T.K., Dishovski, C.D., Tzerovski, E.I., & Petrova, I.J. (2001). PHARMACOKINETIC STUDIES ON THREE REACTIVATORS OF CHOLINESTERASE. Vojenské Zdravotnické Listy, 70(Suppl.1), 33-34
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