MMSL - In Press
USABILITY OF MILITARY HEALTH SERVICE TO SUPPORT AN INTEGRATED RESCUE SYSTEMReview article
Vojtěch Humlíček, Josef Fusek
MMSL X:X | DOI: 10.31482/mmsl.2024.014 
The Military Health Service of the Czech Army can support the Integrated Rescue System in the Czech Republic in dealing with emergency and crisis in cases where the basic components cannot ensure the execution of rescue work and clean-up operation by their own forces. The aim of the article is to evaluate the real possibilities of deploying the forces and resources of the Military Health Service to support the integrated rescue system from the point of view of valid legal and internal regulations and to analyze their availability. It was found that the fundamental conditions for the support of the Integrated Rescue System are regulated in the current...
DESIGN, CHEMICAL SYNTHESIS, AND IN VITRO EVALUATION OF NOVEL UNCHARGED CHOLINESTERASE REACTIVATOROriginal article
Vendula Hepnarova, Martina Hrabinova, Jakub Opravil, Mojmir Vanek, Eva Mezeiova, Lukas Gorecki, Tomas Kucera, Daniel Jun, Ondrej Soukup, Lubica Muckova, Jan Korabecny
MMSL X:X | DOI: 10.31482/mmsl.2024.015
The primary toxicological mechanism of organophosphorus compounds (OPCs) is the irreversible inhibition of acetylcholinesterase (AChE), leading to the accumulation of acetylcholine and subsequent cholinergic crisis, which can result in fatal respiratory failure. Conventional oxime reactivators, such as pralidoxime and obidoxime, are limited by their inability to permeate the blood-brain barrier (BBB) and inconsistent efficacy across different OPC types. To address these limitations, we designed a novel non-quaternary oxime reactivator codenamed K1396, with enhanced lipophilicity for improved BBB penetration and dual-binding capability at both the peripheral...
CAROTID ARTERY DISSECTION AND CONNECTIVE TISSUE DISORDERS: A REVIEW OF KNOWN GENE/PROTEIN MUTATION FINDINGSReview article
Petr Malý, Leona Chrastinová, Martin Malý, Jan M. Horáček
MMSL X:X | DOI: 10.31482/mmsl.2024.016
In this review, we comprehensively analyze the existing literature on the association between connective tissue disorders (CTDs) and carotid artery dissection (CAD), focusing on proven gene and protein mutations. By synthesizing evidence from various studies, we aim to provide a clearer understanding of the underlying mechanisms and potential genetic factors involved in the development of this condition. CAD, a leading cause of stroke in young adults, has been linked to CTDs such as Ehlers-Danlos syndrome, Marfan syndrome, and Loeys-Dietz syndrome, all of which involve genetic mutations that weaken vascular connective tissues. The review reveals that...
THE IMPACT OF SIMULATION METHOD AND ENVIRONMENT ON STRESS LEVELS AND PERFORMANCE IN MILITARY PARAMEDICS: A PILOT STUDYOriginal article
Jan Páleník, Michal Soták, Karel Roubík, Mikuláš Kosák, Martin Pochop, Adéla Bubeníková, Tomáš Tyll
MMSL X:X | DOI: 10.31482/mmsl.2024.017
Background: Medical simulation is widely recognized as an essential component of healthcare professional training, including in military training programs around the world. Combat medicine presents unique challenges that can affect the quality of care provided. We aimed to analyze the benefits of medical simulation in the training of combat paramedics.Methods: Two groups of military medics underwent a simulation scenario. One group had previously completed a simulation training with a full-body mannequin, while the second group completed the same training under simulated battle conditions with using imitations of real injuries. The speed and precision...
EFFECTIVE FORWARDED SURGICAL CARE IN THE ARMY OF THE CZECH REPUBLIC AND THE WORLDReview article
Jan Brixi
MMSL X:X | DOI: 10.31482/mmsl.2025.001
This topic is probably the most important in the field of military healthcare in the long term, because care of this nature is the very reason why the whole sector was created. Effective forwarded surgical care is a crucial factor in reducing preventable battlefield casualties, known and developed since the historical beginnings of military healthcare. This highly demanding medical discipline is an absolutely essential component of the modern war effort, in which it takes on a whole new dimension thanks to unimaginable technological, medical and military-tactical progress. The changed character of the world's main battlefields seems to be crucial at...
TRENDS IN ORAL ANTICOAGULANT PRESCRIPTION PATTERNS IN THE CZECH REPUBLIC: A RETROSPECTIVE ANALYSIS OF 2019–2024Original article
Tomas Veleta, Jiri Vlcek, Jiri Cyrany, Radovan Maly, Tomas Soukup
MMSL X:X | DOI: 10.31482/mmsl.2025.002
Background: The patterns of oral anticoagulant (OAC) prescription have significantly changed in recent years, with direct oral anticoagulants (DOACs) gradually replacing warfarin. While this transition occurred earlier in some countries, limited data are available about its timeline in the Czech Republic.Objectives: This study aimed to analyse trends in OAC prescriptions in the Czech Republic from 2019 to 2024, focusing on the shift from warfarin to DOACs and the patterns of utilisation of individual DOACs.Methods: A retrospective analysis was conducted using national electronic prescription data from the State Institute for Drug Control (SÚKL). Annual...
RESILIENT PLATFORM FOR MICROBIOME DATABASES: ESSENTIAL ATTRIBUTESReview article
Tomáš Ráčil, Petr Františ, Alexandr Štefek
MMSL X:X | DOI: 10.31482/mmsl.2025.003
The rapid growth of microbiome research is hindered by significant challenges in data management, including data fragmentation across disparate silos, a lack of methodological standardization, and barriers to advanced privacy-preserving analysis. To address these issues, this article proposes a conceptual architectural blueprint for a resilient, scalable, and integrated platform for microbiome data. Our proposed architecture is a modular, cloud-native system designed to support the entire research lifecycle. Key attributes include a multi-layered microservices framework to ensure scalability, adherence to FAIR (Findable, Accessible, Interoperable,...
BLOOD DONOR MOTIVATION IN THE CONTEXT OF SOCIODEMOGRAPHIC CHARACTERISTICS AND MOTIVATIONAL FACTORSOriginal article
Pavlína Rabasová, Karel Pavlica, Roman Pospíšil, Hana Konečná, Zuzana Čermáková
MMSL X:X | DOI: 10.31482/mmsl.2025.004
Introduction: The motivation of donors to donate substances of human origin, such as blood and its components, bone marrow, gametes, and others, is influenced by various factors, such as sociodemographic characteristics, motivational factors, and the level of social competence.Aim: To describe and analyse the motivation of donors to donate blood and blood components in relation to sociodemographic characteristics and motivational factors at the Blood Centre of the University Hospital Ostrava.Design and Methods: Quantitative research based on an anonymous questionnaire survey, followed by inferential analysis of bivariate data. The self-designed questionnaire...
MAPPING CHALLENGES, STRATEGIS, AND PREPAREDNESS NEEDS OF ESSENTIAL SERVICES DURING THE COVID-19 PANDEMIC AND FUTURE VIRAL SERVICESOriginal article
Vanda Bostik, Aneta Markova, Radka Prazdna, Adela Mojzisova, Petra Bendova, Ivana Havrankova, Zuzana Truhlarova, Pavel Zikl
MMSL X:X | DOI: 10.31482/mmsl.2025.005
This study is based on a detailed analysis of the challenges faced by various social services in the Czech Republic during the COVID-19 pandemic. The study took into account a combination of several different data sources and included an analysis of recommendations issued during the pandemic, data from preliminary research conducted among social service providers, a questionnaire survey, and two-phase qualitative focus group interviews. Data on residential, outpatient, and field social services in the Czech Republic were collected. The main objective of the research was to map the difficulties these services faced, their working strategies and responses...
MODULATION OF AUTISM SYMPTOMS IN A 13-YEAR-OLD BOY BY FOOD SUPPLEMENT JUVENILCase report
Jela Hrnciarova, Anna Hanusova, Tereza Horakova, Josef Fusek, Klara Kubelkova, Ales Macela
MMSL X:X | DOI: 10.31482/mmsl.2025.006
Antidepressants, antipsychotics, anti-anxiety drugs, or sleeping pills are most often used to treat autism spectrum disorders. The treatment thus focuses on the manifestations accompanying autism, such as inattention, irritability, or sleep disorders, but does not address the essence of the social deficits of autistic children. In addition, drug treatment is often poorly tolerated. Since a certain association of autism with gut microbiota dysbiosis has been demonstrated, and given the existence of the microbiota-gut-brain axis, it can be assumed that modulation of the gut microbiota could contribute to the treatment of the essence of some Autism Spectrum...