MMSL, 2023 (vol. 92), issue 2
IMMUNE DEREGULATION IN MYELODYSPLASTIC SYNDROMES – THE ROLE OF CYTOKINES AND SOLUBLE ADHESION MOLECULES. A PILOT STUDYOriginal article
Tomáš Kupsa, Jan M. Horáček, Petra Bělohlávková, Martin Štajer, Ladislav Jebavý, Martin Jakl, Pavel Skořepa, Pavel Žák
MMSL 2023, 92(2):98-104 | DOI: 10.31482/mmsl.2022.028 
A significant effort has been made to innovative treatment approaches in majority of haematooncologic diseases including myelodysplastic syndromes. Adopting novel therapies brings new questions about enhancing their efficacy. Increasing evidence show a significant role of tumour microenvironment, which compounds of cytokines, chemokines, soluble adhesion molecules, specific T-lymphocyte populations and further populations of antigen presenting cells.In this article, we publish results of our pivotal trial analysing serum levels of cytokines, chemokines and soluble adhesion molecules in patients with high-risk myelodysplastic syndromes treated with...
EVALUATION OF MALONDIALDEHYDE, HOMOCYSTEINE AND ANTIOXIDANT INFLUENCE CHEMOTHERAPY IN BREAST CANCER PATIENTSOriginal article
Tarteel A. Hamza, Sinan Adnan Muhsin, Talat Tariq Khalil
MMSL 2023, 92(2):105-111 | DOI: 10.31482/mmsl.2022.027
The study was designed to evaluate the medical relevance of total homocysteine (tHcy), total antioxidant capacity (TAC), and malondialdehyde (MDA) before and after chemotherapy for women with breast cancer (BRCA). Blood samples were taken from Oncology Unit in Merjian Teaching hospital in Hilla city (Iraq). Sixty patients suffering from breast cancer (BRCA) were enrolled in this study, and twenty-one apparently healthy subjects were considered as a control group control. We found that significantly increased lipid peroxidation, measured as MDA, was demonstrated in the serum of BRCA patients who were not taken any medication was higher than in the control...
A DECLINE IN VITAMIN K AND SOD LEVELS AND THE CHANGE IN PARP1 AND SIRT1 EXPRESSION MIGHT BE ASSOCIATED WITH PROGRESSION OF BREAST CANCEROriginal article
Zainab T. Abd-alzahraa, Zainab N. Al-Abady
MMSL 2023, 92(2):112-121 | DOI: 10.31482/mmsl.2022.030
Cancer cells have a special energy metabolism that enables them to multiply quickly. Under normal oxygen conditions, the Warburg effect is a distinguishing aspect of cancer metabolism in which anaerobic glycolysis is favored. Enhanced glycolysis also helps to produce nucleotides, amino acids, lipids, and folic acid, all of which are necessary for cancer cell division. In a variety of metabolic processes, including glycolysis, the co-enzyme nicotinamide adenine dinucleotide (NAD) mediates redox reactions. NAD levels that are higher promote glycolysis and supply energy to cancer cells. NAD metabolism, like energy metabolism, is linked in cancer genesis...
ESTIMATION OF OXIDATIVE STRESS AND ANTIOXIDANT CAPACITY IN COVID-19 PATIENTS, CURED PATIENTS AND PERSONS TAKING VACCINEOriginal article
Bushra R Hade, Raheem Al-Mammori, Talat Tariq Khalil
MMSL 2023, 92(2):122-127 | DOI: 10.31482/mmsl.2022.031
The study was designed to evaluate the medical relevance of Malondialdehyde (MDA) (a marker of oxidative stress) and total antioxidant capacity (TAC) in coronavirus disease 2019 (COVID-19) groups, cured groups, and control groups; before and after taking the vaccine. Blood samples were taken from Oncology Unit in Al-Mahaweel hospital in Hilla city. Sixteen patients, sixteen cured patients, thirty control, sixteen subjects were taken one dose of Pfizer vaccine, sixteen subjects were taken two doses of Pfizer vaccine. We found that significantly increased lipid peroxidation, measured as MDA, was demonstrated in the serum of COVID-19 patients and TAC...
NIGERIA’S PUBLIC HEALTH RESPONSE TO THE COVID 19 PANDEMIC THROUGH PAST EBOLA EXPERIENCESReview article
Akinyemi Adetunji, Vanda Bostik
MMSL 2023, 92(2):128-134 | DOI: 10.31482/mmsl.2022.044
This article aims to analyze how Nigeria, the 86th ranked State according to the Global Health Security Index (GHS Index), fared through the Covid-19 pandemic by linking its Ebola experience to the pandemic response. The paper will tackle (one of) these questions: Does their response as a State truly reflect the ranking? Or were they, like the rest of the world, truly unprepared and powerless against the outbreak?
EFFECTS OF FORMULATED TOPICAL NIFEDIPINE OINTMENT ON TGF–β AND ACCELERATION OF FACIAL SKIN WOUND HEALING IN RABBITSOriginal article
Wasan J. Al-Dabbagh, Faehaa A. Al-Mashhadane, Ayad A. Al-Sarraj
MMSL 2023, 92(2):135-140 | DOI: 10.31482/mmsl.2022.032
The purpose of this study was to evaluate the impact of 1% and 2% topical nifedipine ointments on TGF–β and the acceleration of facial skin wound healing in rabbits. Nifedipine ointments of 1% and 2% were prepared. Fifty healthy male rabbits were involved and distributed into two groups according to the study period: group A (7 days) and group B (14 days). Each group was subdivided into five groups (5 rabbits/group): Group I (Normal): rabbits did not undergo a surgical procedure and did not receive treatment; group II (negative control): rabbits had surgical wounds without treatment; group III (positive control): rabbits had surgical wounds...
IMPACT OF VITAMIN D3 SUPPLEMENTATION ON DENTAL IMPLANT STABILITYOriginal article
Omer W. Salih, Faehaa A. Al-Mashhadane, Rayan S. Hamed
MMSL 2023, 92(2):141-147 | DOI: 10.31482/mmsl.2022.035
Objectives: The goal of this study was to see how systemic vitamin D3 supplementation affected the durability of dental implants as assessed by radiofrequency analysis.Methods: This split-mouth clinical trial included a total of twelve patients seeking dental implant therapy, ranging in age from 25 to 50 years. The patients were divided into control group and treatment group. Each patient in both groups received dental implants in posterior maxillary extraction sites. The radiofrequency analysis (RFA) was conducted using Osstell Mentor device to evaluate the stability of dental implant at various time points.Results: During the three months of the...
THE ROLE OF CARTILAGE INTERMEDIATE LAYER PROTEIN2 (CILP2) IN EVALUATING THE EFFECT OF TREATMENTS (PLATELET-RICH PLASMA AND HYALURONIC ACID) ON PATIENTS WITH EARLY KNEE OSTEOARTHRITISOriginal article
Ali K. Albdeery, Ajil A. Alzamily, Ihsan A. Alsalman
MMSL 2023, 92(2):148-158 | DOI: 10.31482/mmsl.2022.036
Background: Cartilage intermediate layer protein 2 (CILP2) is a monomeric glycoprotein that is mostly expressed in the intermediate zone of articular cartilage and can be detected in the extracellular matrix (ECM). The level of CILP2 in serum and its quantity on the articular cartilage surface and throughout the articular cartilage indicates the potential utility of CILP2 for investigation as a biomarker for determining cartilage deterioration in joint disorders. The CILP2 measurement of changes in cartilage biomarkers may be an effective and sensitive tool for detecting the early development of knee osteoarthritis (KOA) in people at risk for KOA....
SOLUBILITY ENHANCEMENT OF PIROXICAM USING DIFFERENT CONCENTRATIONS OF THE HYDROTROPIC AGENT SODIUM BENZOATEOriginal article
Rasha Khalid Dhahir
MMSL 2023, 92(2):159-164 | DOI: 10.31482/mmsl.2022.033
Background: Piroxicam is a non-steroidal anti-inflammatory drug, used to alleviate inflammatory signs and symptoms. It is a potent acidic drug that presents mainly in unionized form in the stomach, thus it has a high permeability through the stomach, but poor aqueous solubility. This study, tried to explore the application of hydrotropes to improve the solubility of piroxicam by using different concentrations of the hydrotropic agent sodium benzoate.Methods: Maximum absorbance of piroxicam and its calibration curve was determined using methanol as a solvent, saturated solubility of piroxicam in distilled water and in various concentrations of sodium...
EFFECTS OF LOCAL GROWTH HORMONE THERAPY ON IGF-1 AND TGF-β DURING FACIAL SKIN WOUND HEALING IN RABBITSOriginal article
Lubna A. Tohala, Faehaa A. Al-Mashhadane, Ayad A. Al-Saraj
MMSL 2023, 92(2):165-173 | DOI: 10.31482/mmsl.2022.038
Growth hormone (GH) the most abundant hormone secreted by the anterior pituitary gland could have a role with other growth factors in wound healing because they can help in the physiological wound healing process.Aims: To investigate the effects of GH on facial skin wound healing in rabbits and to evaluate its effect on "insulin-like growth factor (IGF-1)" and "transforming growth factor- β (TGF-β)" in serum. Material and Method: Thirty healthy male rabbits included in this study were classified into two groups according to the day of euthanization 7 and 14 days of study, each group was subdivided into three groups; negative control group,...
THE IMPACT OF COVID-19 PANDEMIC ON THE DEPRESSIVE SYMPTOMS AND QUALITY OF LIFE AMONG HEALTH WORKERS IN SAUDI ARABIAOriginal article
Durrah Alsallal, Najla Alshabanat, Nourah Alwahhabi, Sireen Shilbayeh
MMSL 2023, 92(2):174-183 | DOI: 10.31482/mmsl.2022.040
Background: During coronavirus disease 2019 (COVID-19) pandemic, workers in the healthcare sector are experiencing high workload, making them susceptible to psychological illness.Purpose: This study aimed to explore the influence of COVID-19 outbreak on the depressive symptoms and quality of life among health workers (HWs) in Saudi Arabia.Methods: In this cross-sectional study, the psychological impact and quality of life were assessed using Patient Health Questionnaire-9 (PHQ-9) and Quality-of-Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q). Results: A total of 151 HWs participated in the study, from which 80 participants completed the survey...
HYPERLIPIDEMIA CONNOTED VITIATION OF SERUM ADIPOKINES AND REDOX IMBALANCESOriginal article
Jehan A. Mohammad, Fatimah Haitham Fathi, Ammar A.Y. Almulathanon, Marwan M. Merkhan
MMSL 2023, 92(2):184-190 | DOI: 10.31482/mmsl.2023.016
Background and objectives: Atherosclerosis is the underlying pathology of ischemic heart disease. There are many aggravating metabolic and oxidant parameters which are participating together overwhelming the pathology of vascular stenosis. Adipokines play a positive metabolic effect in healthy individuals and oxidation reaction greatly impacts the lipid metabolism and might negatively impact the condition. In the present study, we aimed to characterize the level of adiponectin, obestatin, and redox parameters in atherosclerotic patients.Methods: Serum was collected from atherosclerotic patients and froze to be ready for analysis.Results: The results...
THE HEALTH DAY IN VYŠKOV AS A EXAMPLE OF PRIMARY PREVENTION IN THE ARMY OF THE CZECH REPUBLICLetter to the editor
Petr Lašák, Vladimír Pavlík, Václav Šafka, Blanka Kupsová, Martin Doležel
MMSL 2023, 92(2):191-192
The author describes the possibilities of primary prevention in the form of an organized Health Day in Vyškov garrison. The author emphasizes the importance of preventive intervention programs and the significance of regular physical activity in the ACR. He describes the advantages of the Diers pedoscan pedometer.