MMSL, 2024 (vol. 93), issue 3
THE IMPACT OF THE COVID-19 PANDEMIC ON CZECH SOCIAL WORKERS ON THE FRONTLINEOriginal article
Aneta Marková, Radka Prázdná, Zuzana Truhlářová, Pavel Zikl, Petra Bendová, Ivana Havránková, Adéla Mojžíšová, Vanda Boštíková
MMSL 2024, 93(3):232-246 | DOI: 10.31482/mmsl.2023.030 
Many biological agents are epidemic or pandemic in nature (Ebola 2013, Spanish influenza 1918, Russian influenza 1989, SARS-CoV-2 2019). Recognising the onset of the spread of epidemics and pandemics remains a major challenge even in the 21st century despite the technologies and scientific knowledge at our disposal, as is the successful management of such situations. The reason concerns the existence of biological diversity and the laws that govern it, which are very difficult to predict and which are virtually uncontrollable. It is gradually becoming apparent that the current spread of SARS-CoV-2 that causes COVID-19 (9 million deaths since...
OXIDATIVE STRESS ALTERS THE THERAPEUTIC EFFECTS OF KETOROLAC IN THE CHICKS MODELOriginal article
Rafal L. Abdulah, Yaareb J. Mousa
MMSL 2024, 93(3):247-254 | DOI: 10.31482/mmsl.2023.029
The purpose of the research consisted of assessing the modification produced by hydrogen peroxide (H2O2)-induced oxidative stress (OS) on the ketorolac therapeutic effects in the chickens which are the analgesic, antipyretic, and anti-inflammatory. A significant decrease in the total antioxidant capacity (T-AOC) and subsequent occurrence of OS was observed in the stressed (H2O2) group on days 7th, 10th, and 14th by 39, 29, and 41%, respectively in comparison to the control (non-stressed) group. The analgesic effect of ketorolac in the stressed group had more intense in comparison...
MICROEMULSION: A POTENTIAL APPROACH FOR TRANSDERMAL DELIVERY OF SILDENAFIL CITRATEOriginal article
Ali Alazzo, Mohanad Alfahad, Mahmood H. M. Jasim, Radhwan Nidal Al-Zidan
MMSL 2024, 93(3):255-263 | DOI: 10.31482/mmsl.2023.031
Sildenafil citrate has low oral bioavailability, systemic adverse effects, and a relatively delayed action. These issues may be addressed through direct transdermal delivery to the penis. This study aims to investigate the microemulsion formulation of the drug for effective transdermal delivery. Sildenafil citrate was formulated as a microemulsion using clove oil, dimethyl sulphoxide, phosphate buffer (pH 7), propylene glycol, Tween®80, and distilled water. Different proportions of these components were used to create six formulations of the microemulsion (F1–F6), which were then characterised by their physical appearance and...
CIRCULATING MICRORNA-22 AS A BIOMARKER RELATED TO OXIDATIVE STRESS IN HYPOTHYROID WOMEN PATIENTOriginal article
Zahraa Mohammed Ali Abd, Nawal Khinteel Jabbar
MMSL 2024, 93(3):264-273 | DOI: 10.31482/mmsl.2023.032
Background: Recent research has linked the spread of microribonucleic acid (miRNA) to numerous disorders, either as a stimulant or an inhibitor. One of these is miRNA-22, which research has connected to oxidative stress and thyroid issues. However, the underlying mechanisms are unknown. This study investigates the expression of miRNA-22 in hypothyroid women and its relationship to the rise in oxidative stress in the patient population.Materials and Methods: 40 women patients with Hypothyroid and 40 in this study, healthy volunteers who served as controls were included. The levels of serum luteinizing hormone (LH), follicle-stimulating hormone (FSH),...
THE ROLE OF SERUM MIDKINE IN THE DIAGNOSIS AND PROGNOSIS OF THE COLORECTAL CARCINOMAOriginal article
Ali H. Abd-Allah, Haider A. Jabbar, Mazen J. Ibrahim
MMSL 2024, 93(3):274-287 | DOI: 10.31482/mmsl.2023.034
Background: The second-leading source of neoplasm-related death and a primary factor in gastrointestinal cancer, colorectal cancer (CCR) affects both genders globally. Poor eating behaviours, tobacco, an intestinal inflammatory disorder, swellings, inherited characteristics, and the elderly all increase the threat of acquiring this malignancy. The illness is more hostile in patients detected at earlier ages, although 90% of patients with colorectal tumours are older than 50, with a median oldness of 64 years. American Cancer Association estimates that it caused more than 49,700 fatalities in 2015.Objectives: Study the correlation of midkine with carcinoembryonic...
AUTOLOGOUS FAT REINJECTION AFTER PRESERVATION AT −2 TO −18°C: A CLINICAL STUDY OF 973 PATIENTSOriginal article
Mohammad Salman Saeed, Qasim S. Al Chalabi, Husam Ali Salman
MMSL 2024, 93(3):288-296 | DOI: 10.31482/mmsl.2023.035
Objective: To study the efficacy of autologous fat transplantation after preservation at −2 to −18°C in a domestic refrigerator.Patients and methods: This study was conducted in a private clinic from December 2017 to December 2021. A total of 973 female patients were included. Under a full aseptic technique, fat was harvested using a 4 mm suction blunt cannula with three longitudinal slits. Three 50 mL syringes of fat were obtained before transferring it to 10 mL syringes; then, the fat was centrifuged at 3500 rpm for 1 min and injected through an 18 gauge blunt cannula. In addition, 50 mL of fat without centrifugation was stored in a domestic...
THE BOON AND BANE OF PARTHENIUM HYSTEROPHORUS FOR HUMAN HEALTHReview article
Mohd Ubed Noor, Sadique Hussain, Sunvej Choudhary, Swati Tyagi, Mudita Mishra
MMSL 2024, 93(3):297-311 | DOI: 10.31482/mmsl.2023.033
The annual or ephemeral plant Parthenium hysterophorus L. is an upright and heavily branched member of the Asteraceae family. The herb is used to treat heart issues, fever, anemia, wounds, and ulcerated sores. It is applied topically to treat skin issues, while the plant’s decoction is frequently taken orally to address a wide range of ailments. Psoriasis, rheumatoid arthritis, diarrhea, urinary tract infections, dysentery, malaria, psoriasis, allergies, asthma, tinnitus, nausea, vomiting, and neuralgia are just a few of the health benefits that P. hysterophorus L. can provide. Asthma, bronchitis, dermatitis, and hay fever...