MMSL, 2024 (vol. 93), issue 2
LIVER ENZYMES AND BIOCHEMICAL FUNCTION TESTS IN T2DM: IMPACT OF DURATION, GLYCEMIC CONTROL AND SOME OTHER CO-VARIABLESOriginal article
Amjad Hazim Al-Naemi
MMSL 2024, 93(2):151-160 | DOI: 10.31482/mmsl.2023.017 
Background and Purpose: T2DM is the most common cause of end- stage liver diseases, and different mechanisms contribute to diabetic hepatopathy’s wide spectrum presentation. In this study, we aimed to identify abnormalities in liver function tests (LFTs) for a group of Iraqi T2DM patients, determine their prevalence, and investigate the influence of some independent co-variables (duration of DM, HbA1c, BMI, age, and gender). Methods: This case-control study enrolled 43 T2DM patients alongside 40 healthy, age- and sex- matched non-diabetic subjects. After overnight fasting, blood was collected, and fasting plasma glucose (FPG), HbA1c, and serum...
EVALUATION OF FREE THYROXINE LEVEL AND BCL11A GENE POLYMORPHISM WITH BETA-THALASSEMIAOriginal article
Mayssam M. Salih, Ahmed G. Al-Ziaydi, Aalan Hadi Al-zamili
MMSL 2024, 93(2):160-166 | DOI: 10.31482/mmsl.2023.018
Background: Thalassemia` is an autosomal recessive hereditary chronic hemolytic anaemia caused by a partial or total deficit in the production of β -globin chains that make up the main adult haemoglobin. Patients with the beta-thalassemia major have changes in thyroid function and result from thyroid function tests. The B-cell lymphoma /leukemia11A (BCL11A) gene is mainly located in the human chromosome 2p16.1 region; the BCL11A gene can regulate the expression of fetal haemoglobin.The aim: analysis of the association between beta-thalassemia and the BCL11A gene polymorphism in the Iraqi patient and to evaluate the effect of beta-thalassemia on...
MICRORNA-122 AS A BIOMARKER ASSOCIATED WITH OXIDATIVE STRESS IN PATIENTS SUFFERING FROM METABOLIC DISEASESOriginal article
Ruqaya S. Reda, Nawal Khinteel Jabbar
MMSL 2024, 93(2):167-175 | DOI: 10.31482/mmsl.2023.020
Background: Recent evidence has shown that circulating microribonucleic acid (miRNA) has been related to many diseases either as an inhibitor or a stimulant factor, among them miRNA-122 which has proven through studies its relationship with insulin resistance, an adversative lipid profile, obesity, type 2 diabetes, and metabolic syndrome in several studies; however, the mechanisms involved are unknown. This study investigates the role of miRNA-122 expression in overweight patients suffering from metabolic disorders such as diabetes and hypertension and its relationship to the development of oxidative stress in patient groups.Materials and Methods:...
ALTERNATIVE COMMUNICATION TOOLS FOR THE ELDERLY IN TIMES OF RESTRICTED SOCIAL CONTACTSOriginal article
Irena Tušer, Jana Pupíková, Eliška Polcarová, Rudolf Urban, Tomáš Zeman, Renata Havránková, Ludmila Čírtková, Tibor Brečka, Hana Kličková, Leoš Navrátil
MMSL 2024, 93(2):176-187 | DOI: 10.31482/mmsl.2023.025
Background and objective: Nursing homes are threatened by external and internal threats, effect of which may result in a crisis situation (state of emergency). While managing an already existing emergency, it is necessary to create conditions allowing the elderly to maintain their fundamental human and civil rights. Any interference with human and civil rights is acceptable only in a state of emergency when crisis measures are applied. Social isolation was one of the emergency measures within the Covid-19 pandemics and involuntary social isolation may result in one´s state of depression. To eliminate this prediction, it is necessary to create such...
PREVALENCE AND DISTRIBUTION OF RESISTANT GENES OF ANTIBIOTICS, HEAVY METALS AND BIOCIDES IN SOME ENTEROBACTERIA SPECIESOriginal article
Samir M. Khalaf, Muhsin A. Essa
MMSL 2024, 93(2):188-192 | DOI: 10.31482/mmsl.2023.024
The problem of bacterial resistance to antibiotics has become a global issue and a major health challenge that requires continuous studies on how this resistance develops and spreads, and its relationship to resistance to other factors such as heavy metals and biocides. The current study aimed to determine the prevalence and distribution of antibiotics, heavy metals, and biocides-resistant genes on the chromosomes and plasmids of some Enterobacteria species. The results showed that antibiotics resistant genes (blaCTX, sul 1) were present in all isolates except for Klebsiella pneumoniae chromosome, while for heavy...
PHARMACOKINETIC OF SINGLE-DOSE ORAL PREGABALIN ADMINISTRATION IN NORMAL CHICKSOriginal article
Qutaiba M. Bashar, Yasser M. Albadrany
MMSL 2024, 93(2):193-198 | DOI: 10.31482/mmsl.2023.027
This study aimed to investigate the concentration of pregabalin in the plasma of chicks to determine its pharmacokinetic parameters. Pregabalin (300 mg/kg) was administered orally to 42 clinically healthy Ross chicks as part of a randomized controlled study. Blood samples were collected from the jugular vein at 0.5, 1, 2, 4, 8, and 24 h after drug administration from six chicks per each time. The concentrations of pregabalin in the plasma samples were determined using a quantitative HPLC assay, and pharmacokinetic parameters were calculated using the PKSolver program. Pharmacokinetic parameters were determined using a noncom-partmental model. The concentrations...
THE IMPACT OF ADHD ON THE PERFORMANCE OF THE PROFESSION OF A PROFESSIONAL SOLDIER AND OTHER RISK FACTORS INFLUENCING THE USE OF ADDICTIVE SUBSTANCES IN ADOLESCENCEOriginal article
Simona Sedláčková, Lidmila Hamplová, Vladimír Pavlík
MMSL 2024, 93(2):199-205 | DOI: 10.31482/mmsl.2023.028
Background: ADHD syndrome is still at the forefront of discussed diagnoses in children, and is a continuing phenomenon even into adulthood. At the same time, the development of substance and non-substance addictions at an early age is a constant problem. The phenomenon of behavioral disorders, hyperactivity, impulsivity, and inattention, resulting from the immature development of brain centers in children, often brings with it persecution from pedagogues and educators. For both children and adults, there is no suggested therapeutic procedure, except for medication, although it is possible to work with the given disorder with an appropriate bio-psycho-social...
PREVENTIVE MEASURES OF RESPIRATORY DISEASES AND IMPACT ON EMPLOYEE MORBIDITY - POSSIBILITIES OF USING ELECTRONIC PLATFORMSReview article
Klára Václavíková, Kristýna Šoukalová, Marcela Kožená, Zdeněk Brodský, Michaela Mandysová, Hana Ochtinská, Karel Šatera, Kateřina Horáčková
MMSL 2024, 93(2):206-217 | DOI: 10.31482/mmsl.2023.019
Aims: Prevention is one of the most effective methods in the fight against respiratory infections. Electronic platforms can streamline care and have positive applications in the case of infectious diseases. This study was conducted to search for and describe the current scientific knowledge on prevention and the use of electronic platforms and their impact on the application of prevention strategies.Methods: A scoping review was conducted. In January 2022, a search was performed in selected licensed and free databases (EBSCOhost, Ovid, Scopus, Web of Science) based on PCC keywords using Boolean operators.Results: A total of 1927 sources were retrieved,...
RESISTIN IN RHEUMATOID ARTHRITISReview article
Fatimah Haitham Fathi, Ammar A.Y. Almulathanon, Jehan A. Mohammad
MMSL 2024, 93(2):218-223 | DOI: 10.31482/mmsl.2023.021
Rheumatoid arthritis (RA) is a chronic multisystem illness that affects millions of individuals. The primary goal of RA therapy is to improve patients' quality of life by reducing pain severity, preserving or improving functional capability, and decreasing disability. The significance of resistin in the pathophysiology of RA has been explored in recent years, although its role is unclear as it is largely produced by macrophages. In this review, we have analyzed 10 studies from the PubMed site that demonstrate a relationship between resistin levels and the severity of RA.
THE CHINESE SURVEILLANCE SYSTEM OF COVID-19 DISEASE IN THE LIGHT OF ARTIFICIAL INTELLIGENCEReview article
Kitti Nagy, Vanda Bostik
MMSL 2024, 93(2):224-230 | DOI: 10.31482/mmsl.2023.023
There are two key sources of data that contribute to biomedicine research: surveillance and questionnaires and interviews. The Centers for Disease Control and Prevention (CDC, Atlanta, GA, USA) defines surveillance as the ongoing systematic collection, analysis, and interpretation of health data, essential to the planning, implementation, and evaluation of public health practice, closely integrated with the timely dissemination to those who need to know. The three things to keep in mind about surveillance systems are that they are ongoing (collecting information only once is not a surveillance system), the data collected are used (analyzed and interpreted)...