MMSL, 2019 (vol. 88), issue 3

PERFLUOROISOBUTENE: POISONOUS CHOKING GASReview article

Jiri Patocka

MMSL 2019, 88(3):98-105 | DOI: 10.31482/mmsl.2019.006  

Perfluoroisobutene (PFIB) is a colorless toxic gas which can be absorbed into the body by inhalation. The substance irritates the respiratory tract and may be used as a potential chemical warfare agent.  Inhalation exposure may cause severe symptoms of pulmonary edema associated with wheezing, difficulty in breathing and sputum expectoration. A bluish skin color is also observed. Initially, cough and chest pain may occur. However, severe symptoms of pulmonary edema may be delayed for several hours before a rapid deterioration of health occurs. Excessive exposure may cause death.

NATURAL IMMUNE BOOSTER IMUREGEN SIGNIFICANTLY AFFECTS THE PROLIFERATION OF TUMOR CELLSOriginal article

Klara Duskova, Lucie Cechakova, Lenka Plzakova, Zuzana Sinkorova, Klara Kubelkova

MMSL 2019, 88(3):106-114 | DOI: 10.31482/mmsl.2019.007  

Background. Extracts from plant and/or animal tissues are frequently used in alternative medicine as drugs or food supplements. Such extracts may contain a complex of pharmacologically or physiologically active factors but frequently there exists no experimental confirmation as to precise mechanisms of action. This work aimed to verify if a long used bovine blood extract Imuregen registered as a food supplement has desirable effect on tumor cells.Methods. Two independent methodological approaches were used. Viability of cell cultures was evaluated using WST-1-based cell cytotoxicity assay. Cell growth was monitored in real time using xCELLigence cell...

A SHORT HISTORY OF IMUREGEN – AN ORIGINAL TISSUE EXTRACTReview article

Klara Kubelkova, Ales Macela

MMSL 2019, 88(3):115-120 | DOI: 10.31482/mmsl.2019.008  

Imuregen is a unique dietary supplement that was developed by leading Czech immunologists, made and distributed from the Czech Republic, and first came out in the 1950s. Imuregen boasts of decades of research and clinical exposure. It was created for the immune system sourced only from all natural ingredients that support cellular immunity and energy, tissue regeneration, wound healing, endocrine gland repair, intestinal integrity, memory enhancement, and has antitumor effects.

PROPHYLACTIC AGENTS IN THE MANAGEMENT OF ORGANOPHOSPHORUS INTOXICATIONReview article

Barbora Svobodová, Lukáš Górecki, Jan Korábečný

MMSL 2019, 88(3):121-133 | DOI: 10.31482/mmsl.2019.016  

Nerve agents (NAs) belong to family of organophosphorus inhibitors (OPIs) of acetylcholinesterase (AChE) enzyme. Although the use of highly toxic OPIs as chemical warfare agents is prohibited, they have been misused several times and thus still represents an emerging threat. For these reasons, the development of novel prophylactic agents and therapeutic intervention against NAs is still up-to-date and of high importance. Prophylactic administration of antidotes not only increases body's resistance to the effects of NAa, e.g. when operating at a contaminated environment after a terrorist attack, but also potentiates the subsequent antidotal therapy...

SUCCESSFUL EMERGENCY THORACOTOMY FOR BLAST INJURY: A CASE REPORTCase report

Radek Pohnán, Vladislav Hytych, Radek Doležel

MMSL 2019, 88(3):134-138 | DOI: 10.31482/mmsl.2019.012  

Exsanguination is one of the leading causes of death in a battlefield. Patients who require cardiopulmonary resuscitation after moribund trauma have an unfavorable prognosis. The determinant of survival in critically injured is a time to surgical intervention. Resuscitative emergency thoracotomy may be the lifesaving treatment in selected patients with trunk trauma and cardiac arrest after hemorrhagic shock.This is a case report of successfully applied resuscitative surgical techniques in severely injured allied soldier with hemorrhagic shock and cardiac arrest after suicide bomber explosion. A prompt diagnosis and a rapid emergency thoracotomy are...

INTERNAL MEDICAL DISCIPLINES IN THE MINISTRY OF DEFENCE – THE CURRENT STATE AND OPTIONS FOR FURTHER DEVELOPMENTOriginal article

Jan M. Horáček

MMSL 2019, 88(3):139-148 | DOI: 10.31482/mmsl.2019.014  

Internal medical disciplines (internal medicine and other internal specialties) are among the key clinical branches for the Ministry of Defence and the military medical service. The work provides an overview of the current state of internal medical disciplines within the Ministry of Defence. The main problem is the lack of qualified medical personnel and a complicated system of specialized training due to complexity of these fields. The results section provides options for the further development of internal medical disciplines to secure fulfilment of tasks of military medical service in favour of the Ministry of Defence, in the field of therapeutic-preventive,...