MMSL, 2019 (vol. 88), issue 4
THE INFLUENCE OF TOTAL PARENTERAL NUTRITION ON THE METABOLISM OF NON-ESTERIFIED FATTY ACIDS IN CRITICALLY ILL PATIENTS: ONGOING DATA FROM A PROSPECTIVE RANDOMIZED STUDYOriginal article
Pavel Skořepa, Joao Fortunato, Ondřej Sobotka, Alena Tichá, Vladimír Bláha, Luboš Sobotka, Jan M. Horáček
MMSL 2019, 88(4):150-158 | DOI: 10.31482/mmsl.2019.015 
Introduction: Metabolic changes induced by stress reaction are, among other things, characterized by increased turnover of non-esterified fatty acids (NEFA), which results in an increase in their plasma concentration. The aim of the study was to determine how intravenous nutritional support (TPN) will affect the concentration of NEFA in critically ill individuals. Methods: 38 patients in averaged 65 ± 11 years old hospitalized in a medical intensive care unit of university hospital in years 2015-2018 were examined. They were given isocaloric (30 kcal/kg/day) and isonitrogenic (1.8 g/kg/day) TPN in combination with glucose (5.8 g/kg/day; glucose...
BRAIN ENERGETIC DEMANDS DURING COGNITIVE ACTIVITIES IN RELATION TO AEROBIC LOADReview article
Vladimir Michalicka, Radek Pohnan
MMSL 2019, 88(4):159-165 | DOI: 10.31482/mmsl.2019.013
Fatigue is common clinical issue, where previous effort, whether physical or mental leads to a reduction in the ability to perform activities. Fatigue severely affects human performance and error rate. Recently, in addition to researching physical fatigue, great emphasis has been placed on research into mental fatigue. The relationship between the two types of fatigue is intensively investigated. Exploration of fatigue and its impact on job performance in high-risk military occupations aims to reduce error rates and eliminate potentially large damage, injuries and loss of life. In this review are described the basic theses of fatigue, physiological...
PHARMACOLOGICAL PROFILE OF DIZOCILPINE (MK-801) AND ITS POTENTIAL USE IN ANIMAL MODEL OF SCHIZOPHRENIAReview article
Jan Konečný, Radomír Jůza, Ondřej Soukup, Jan Korábečný
MMSL 2019, 88(4):166-179 | DOI: 10.31482/mmsl.2019.019
N-Methyl-D-aspartate (NMDA) receptor belongs to the group of glutamate receptors, which are further divided into ionotropic and metabotropic. It affects synaptic plasticity and the development of neuronal synapsis in CNS. Ionotropic NMDA receptors are activated by glutamate, thereby flowing positively charged ions through the membrane along its concentration gradient. However, glutamate overload leads to excitotoxicity, due to high levels of Ca2+, which leads to cell death assocciated with neurodegenerative diseases. NMDA antagonists like dizocilpine reduce intracellular concentration of Ca2+ by modulating permeability...
TREATMENT OF HEMOTHORAX IN THE ERA OF THE MINIMALY INVASIVE SURGERYReview article
Radek Pohnán, Šárka Blažková, Vladislav Hytych, Petr Svoboda, Michal Makeľ, Iva Holmquist, Miroslav Ryska
MMSL 2019, 88(4):180-187 | DOI: 10.31482/mmsl.2019.011
Hemothorax is a frequent clinical situation often associated with chest injury or with iatrogenic lesions. Spontaneous hemothorax is uncommon and among its cause may include coagulation disorders, pleural, pulmonary or vascular pathology. Diagnostics is based on radiography or ultrasound and thoracentesis which may be also therapeutic solution. The majority of hemothoraxes can be managed non-operatively but hemodynamic instability, the volume of evacuated blood and persisting blood loss or persisting hemothorax require surgery. A surgical approach may vary from open thoracotomy to rapidly developing minimally invasive methods - video-assisted thoracoscopic...
THE IMPACT OF CATERING ON THE HEALTH AND LIFE SATISFACTION OF COALITION SOLDIERS DURING THEIR DEPLOYMENT ON A MILITARY OPERATIONReview article
Tomas Vasek, Jaroslav Zdara, Zbynek Suchanek, Petr Lasak, Jana Fajfrova
MMSL 2019, 88(4):188-194 | DOI: 10.31482/mmsl.2019.021
The following thesis focuses on the issues regarding catering and food and its impact on health and life satisfaction of coalition soldiers during their deployment on a military operation in the Middle East area. Obviously, food is a part of our lifestyle and it is certainly an area affecting our life satisfaction, all the more affecting the life satisfaction of soldiers specifically in an armed conflict environment where they are exposed to higher stress conditions. Furthermore, life satisfaction is one of the variables influencing the work itself. And work influences our lifestyle and vice versa. It can be also said that life satisfaction influenced...
DECONTAMINATION OF HIGH-RISK BIOLOGICAL AGENTS – SPRAYING CHALLENGESReview article
Aleš Rybka, Alan Gavel, Jakub Meloun, Lucie Tichá, Jaroslav Pejchal
MMSL 2019, 88(4):195-200 | DOI: 10.31482/mmsl.2019.023
Many unfavourable factors can affect decontamination efficacy when personnel wearing personal protective equipment are decontaminated prior to their final exit from the hot zone. One of the most important factors is the quality of aerosol, which is determined mainly by the size and amount of droplets. Aerosol quality is closely related to the target area coverage efficacy or to deflection of droplets from the direction of flight, so called drift. Studies comparing, e.g., droplet size, velocity, trajectory, spray height, viscosity, surface tension, and wind speed are scarce. The quality of spraying and its application have been intensively studied by...
THE DOUBLE DUCT CYSTICUS: RARE FINDING AT CHOLECYSTECTOMYCase report
Jaroslav Verner, Petr Chmátal, Jiří Chrobok, Jakub Tlapák
MMSL 2019, 88(4):201-204 | DOI: 10.31482/mmsl.2019.020
The case report presents a case of a very rare anomaly of bile ducts. A 57-year-old patient underwent elective laparoscopic cholecystectomy. The double duct cysticus was the reason of conversion to open surgery. The findings was confirmed due perioperative cholangiography and histological conclusion. This rare abnormality can cause serious surgical accidents. We present our case to point out possible risks of routine laparoscopic cholecystectomy.