MMSL, 2023 (vol. 92), issue 1
BIOCHEMICAL STUDY OF SERUM β-HYDROXYBUTYRATE DEHYDROGENASE IN β-THALASSEMIAOriginal article
Hiba N. Sami, Mahmoud A. M. Fakhri
MMSL 2023, 92(1):2-13 | DOI: 10.31482/mmsl.2022.013 
Introduction: Thalassemia is a healthcare challenging disease all over the world. It imparts a great burden on patients’ families and healthcare institutions. Scientists focus on new aspects to overcome these challenges and increase patient tolerance of disease complications. This study aims to quantify β-Hydroxybutyrate Dehydrogenase BHBDH activity in thalassemia patients compared to the control group and their correlation with the patient's demographic characteristics.Methods: To do so, serum was collected from patients and the control group and analyzed biochemically for targeted laboratory tests. We determined β-Hydroxybutyrate...
VITAMIN E VERSUS PROPOLIS AS AN ADD-ON THERAPY TO SITAGLIPTIN/METFORMIN ON OXIDANT/ANTIOXIDANT STATUS AND LIPID PROFILE IN TYPE 2 DIABETIC PATIENTSOriginal article
Sarraa Dhiaa, Imad A. Thanoon, Nabeel N. Fadhil
MMSL 2023, 92(1):14-21 | DOI: 10.31482/mmsl.2022.015
The main health care challenges associated with diabetic patients are glycemic control. Insulin defection has been regarded as the mainstay which needs to be tackled to avoid glucose over presence in the circulatory system. These challenges have always been conjoined with the patient’s redox status, hence, oxidants/antioxidants determine the fate of pancreatic tissue status and they are reciprocally interrelated. Various remedies have been utilized by patients themselves and healthcare workers to control hyperglycemia if any. Herbal and pharmacological therapy were always being used hand in hand. Herein, we are demonstrating the antioxidant...
DRUG-INDUCED ACUTE PANCREATITIS – LITERATURE OVERVIEW AND OUR EXPERIENCEReview article
Ján Csomor, Petr Hříbek, Petr Urbánek
MMSL 2023, 92(1):22-28 | DOI: 10.31482/mmsl.2022.016
Drug induced acute pancreatitis is worldwide a very rare cause of acute pancreatitis at all. In the literature and in the statistics it comprises only 0.1-2 % of all cases of acute pancreatitis. Nowadays, more than 200 potential dangerous drugs are specified, that they can cause acute pancreatitis. The exact mechanism of this adverse drug reaction is still unclear and to establish the diagnosis one has to exclude more common form of acute pancreatitis (caused especially by gallstones and alcohol) and find the time connection with recieving a new, risky medication.
SLEEP DURATION IN STUDENTS OF THE UNIVERSITY OF DEFENSEOriginal article
Jiří Néma, Hynek Schvach, Vladimír Pavlík, Pavel Blažek
MMSL 2023, 92(1):29-35 | DOI: 10.31482/mmsl.2022.018
Sufficiently long and quality sleep is essential for maintaining long-term health, the ability to learn new things and prevent of civilization diseases. Excessive stress and many work and study responsibilities can lead to the reduction of sleep needed. Within our investigation, we decided to chart the length of sleep at the students of the University of Defense and asses their sleep habits considering, besides their study duties, also the loading by military duties and this load may lead to inappropriate sleep habits. Three questions were asked for our research:1) To Find out how long the University of Defense students sleep on working and non-working...
PHYTOCHEMICAL AND PHARMACOLOGICAL REVIEW ON ORIGANUM VULGARE: A POTENTIAL HERBAL CURE-ALLReview article
Zena Sideek Tawffiq, Ammar A.Y. Almulathanon
MMSL 2023, 92(1):36-47 | DOI: 10.31482/mmsl.2022.021
Origanum vulgare (O. Vulgare) is a medicinal and aromatic shrub. It is commonly used as a culinary spice and in "traditional medicine" to cure a variety of diseases. Almost all parts including roots, leaves, stems, and flowers, are employed in medical systems to treat a variety of ailments. In recent scientific literature, among other things, the plant was reported to behave clinical effectiveness against antibacterial, hyperglycemia, anthelminthic and antifungal actions. Carvacrol, limonene, thymol, ocimene, pinene, caryophyllene, terpenes-cymene, and other significant medicinal chemicals have been extracted from this genus through phytochemical...
CHITOSAN NANOPARTICLES AS DELIVERY SYSTEM FOR NASAL IMMUNISATIONReview article
Sylva Janovska, Radek Sleha, Marcela Slovakova, Ludovit Pudelka, Pavel Bostik
MMSL 2023, 92(1):48-56 | DOI: 10.31482/mmsl.2022.023
Nasal immunisation represents an innovative and perspective route of vaccine administration that provides many benefits compared to the more traditional approaches. Since most infections start on mucosal membranes, the mucosal immunisation provides a rational reason for its application. Mucosal delivery for vaccine administration (for example oral or nasal routes) could stimulate both systemic and mucosal immune responses. However, there are still some limitations that should be solved for a broader utilisation of this approach. There is still the necessity to use strongly immunogenic antigens or appropriate adjuvants for the induction of a strong...
SIX CUSPS VARIETY OF THE TOOTH CROWN OF THE LOWER FIRST PERMANENT MOLAROriginal article
Marek Grulich, Filip Kulhánek
MMSL 2023, 92(1):57-63 | DOI: 10.31482/mmsl.2022.024
Lower first permanent molars typically have five cusps and two roots. The occurrence of six cusps in the anatomical crown of the teeth is quite rare, especially among the European population, but this anatomical variant is typical for indigenous Australians (1). In this paper, we present a patient's case together with relevant digital documents. We also describe certain conservating, endodontic, surgical, and periodontic risks related to treating such teeth.
ANTIMICROBIAL AND ANTI-OXIDANT ACTIVITIES OF ESSENTIAL OILS DERIVED FROM SOME CITRUS PEELOriginal article
Khadeeja Y. Abid, Maimonah Q. Yahya
MMSL 2023, 92(1):64-74 | DOI: 10.31482/mmsl.2022.025
Essential oils can be used in a variety of ways to treat microorganisms that have evolved antibiotic resistance. The research assessed the antimicrobial and antioxidant activities of essential oil obtained from Citrus Limonum, Citrus reticulate, and Citrus sinensis fresh peels using the hydro-distillation method. Their chemical compositions were analyzed by Gas Chromatography-Mass Spectrometer. Citrus oils had antimicrobial and antioxidant properties and their activity was increased with increasing concentrations. Oils had a significant antimicrobial effect on tested bacteria except on P. aeruginosa only C. Limonum...
PROPOLIS-INDUCED HEPATORENOPROTECTION IN RODENTS EXPOSED TO RIFAMPICIN AND ISONIAZIDOriginal article
Ahmed Abdulsallam, Imad A. Thanoon, Abdulrahman I. Abduljabbar
MMSL 2023, 92(1):75-86 | DOI: 10.31482/mmsl.2022.026
The elimination of most drugs based on liver/renal excretion; making liver and kidneys the commonest target organ for exposure to toxic materials. Long-term use of drugs surpassed the effect and aggravate the toxicity. Tuberculosis (TB) is chronic disease with long-term therapy and the deleterious impact of antitubelculosis is certain. Various pharmacokinetic manoveuors were proposed to avoid the potential harmful effect of TB therapy. The present study aimed at mitigating the destructive effects of TB therapy using propolis. To do so, rats were exposed to isoniazid or rifampicin or a combination of them in groups of 8 rats each for a period of 8-weeks...
PEROXIREDOXIN 3 AND OXIDATIVE STRESS IN RECURRENT ABORTION PATIENTSOriginal article
Israa H. AL-Hamdani, Luay A. Al-Helaly
MMSL 2023, 92(1):87-94 | DOI: 10.31482/mmsl.2022.034
The pаthоphysiolоgy of recurrent spontaneous abortion (RSA) has been linked to oxidative stress (OS), which is defined as an imbalance between the formation of oxidants and the antioxidant defense system. The goal of this study was to assess the state of OS in recurrent spontaneous abortion by assessing some of its indicators in order to identify women who are at risk of abortion and enhance their reproductive health. Peroxiredoxin 3 (Prx3), progesterone (P4), glutathione (GSH), uric acid (UA), pеrоxynitritе (ONOO-), and mаlоndialdеhyde (MDA) were measured in 40 healthy non-pregnant (HNP)...
OBITUARY: Prof. WILLIAM GUNN, MD, MS, FRCSC, FRCSI (Hon), DSC (Hon), dr.h.c. (10. 2. 1926 - 1. 11. 2022)Letter to the editor
Leo Klein
MMSL 2023, 92(1):95-96
Professor Sisvan William Aram Gunn, a world-renowned authority on disaster medicine, a pioneer in the field of emergency medical systems and humanitarian medicine, a researcher, organiser and close associate of the represe-ntatives of Czechoslovak and Czech health care, died at the age of 96 in Switzerland, on November 1st, 2022. We have thoroughly featured the Professor’s life and extensive work achievements on his ninetieth birthday (MMSL, 85,2016, (1), 44-46). This brief obituary will recount just a few of his legacy’s most prominent facets.