MMSL 2023, 92(1):36-47 | DOI: 10.31482/mmsl.2022.021
PHYTOCHEMICAL AND PHARMACOLOGICAL REVIEW ON ORIGANUM VULGARE: A POTENTIAL HERBAL CURE-ALLReview article
- College of Pharmacy, Alhadbaa Street, 41002, University of Mosul, Mosul, Ninevah Province, Iraq
Origanum vulgare (O. Vulgare) is a medicinal and aromatic shrub. It is commonly used as a culinary spice and in "traditional medicine" to cure a variety of diseases. Almost all parts including roots, leaves, stems, and flowers, are employed in medical systems to treat a variety of ailments. In recent scientific literature, among other things, the plant was reported to behave clinical effectiveness against antibacterial, hyperglycemia, anthelminthic and antifungal actions. Carvacrol, limonene, thymol, ocimene, pinene, caryophyllene, terpenes-cymene, and other significant medicinal chemicals have been extracted from this genus through phytochemical studies. The phytochemical ingredients of O. vulgare are highlighted in this review and its traditional uses, as well as evidence-based studies on the plant's diverse pharmacological effects. This illustrates the importance of conducting a thorough investigation in order to report new information on the mechanisms of action of these impacts.
Keywords: phytochemistry; Origanum vulgare; Oregano; pharmacological screening
Received: December 24, 2021; Revised: May 14, 2022; Accepted: May 23, 2022; Prepublished online: July 11, 2022; Published: March 3, 2023 Show citation
References
- Ivask K, Orav A, Kailas T, et al. Composition of the essential oil from wild marjoram (Origanum vulgare L. ssp.) cultivated in Estonia. Journal of Essential Oil Research. 2005 Jul 1;17(4):384-7. https://doi.org/10.1080/10412905.2005.9698938
Go to original source...
- Leyva-López N, Gutiérrez-Grijalva EP, Vazquez-Olivo G, et al. Essential oils of Oregano: Biological activity beyond their antimicrobial properties. Molecules. 2017 Jun;22(6):989. https://doi.org/10.3390/molecules22060989
Go to original source...
Go to PubMed...
- Islam MT, da Mata AM, de Aguiar RP, et al. Therapeutic potential of essential oils focusing on diterpenes. Phytotherapy Research. 2016 Sep;30(9):1420-44.
Go to original source...
Go to PubMed...
- Masteliæ J, Milos M, Jerkoviæ I. Essential oil and glycosidically bound volatiles of Origanum vulgare L. ssp. hirtum (Link) Ietswaart. Flavour and fragrance journal. 2000 May;15(3):190-4. https://doi.org/10.1002/1099-1026(200005/06
Go to original source...
- Baricevic D. The Biological-pharmacological activity of the Origanum genus. --p. 177-213. Oregano: the genera Origanum and Lippia. London, GB: Taylor & Francis, 2002.
- Bharti V, Vasudeva N. Origanum vulgare Linn. leaf: An Extensive Pharmacognostical and Phytochemical Quality Assessment. Advanced pharmaceutical bulletin. 2013 Dec;3(2):277. https://doi.org/10.5681/apb.2013.045
Go to original source...
Go to PubMed...
- Lukas B, Schmiderer C, Novak J. Phytochemical diversity of Origanum vulgare L. subsp. vulgare (Lamiaceae) from Austria. Biochemical systematics and ecology. 2013 Oct 1; 50:106-13. https://doi.org/10.1016/j.bse.2013.03.037
Go to original source...
- Mockute D, Bernotiene G, Judzentiene A. The essential oil of Origanum vulgare L. ssp. vulgare growing wild in Vilnius district (Lithuania). Phytochemistry. 2001 May 1;57(1):65-9. https://doi.org/10.1016/S0031-9422(00)00474-X
Go to original source...
Go to PubMed...
- DESHAPRABHU S. The Wealth of India: Raw Materials, Vol. VII; N-Pe. The Wealth of India: Raw Materials, Vol.VII; N-Pe. 1966.
- Wogiatzi E, Gougoulias N, Papachatzis A, et al. Chemical composition and antimicrobial effects of Greek Origanum species essential oil. Biotechnology & Biotechnological Equipment. 2009 Jan1;23(3):1322-4. https://doi.org/10.1080/13102818.2009.10817662
Go to original source...
- Yazdani E, Sendi JJ, Hajizadeh J. Effect of Thymus vulgaris L. and Origanum vulgare L. essential oils on toxicity, food consumption, and biochemical properties of lesser mulberry pyralid Glyphodes pyloalis Walker (Lepidoptera: Pyralidae). Journal of Plant Protection Research. 2014 Jan1;54(1):53-61.
Go to original source...
- Kumar M, Sheikh MA, Bussmann RW. Ethnomedicinal and ecological status of plants in Garhwal Himalaya, India. Journal of ethnobiology and ethnomedicine. 2011 Dec;7(1):32. https://doi.org/10.1186/1746-4269-7-32
Go to original source...
Go to PubMed...
- Prakash O, Kanyal L, Chandra M, et al. Chemical diversity and antioxidant activity of essential oils among different accessions of Origanum vulgare L. collected from Uttarakhand region.
- EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS). Scientific Opinion on the use of Oregano and lemon balm extracts as a food additive. EFSA Journal. 2010 Feb;8(2):1514.
Go to original source...
- Kintzios SE, editor. Oregano: the genera Origanum and Lippia. CRC press; 2003 Aug 27.
Go to original source...
- Esen G, Azaz AD, Kurkcuoglu M, et al. Essential oil and antimicrobial activity of wild and cultivated Origanum vulgare L. subsp. hirtum (Link) letswaart from the Marmara region, Turkey. Flavour and Fragrance Journal.2007 Sep 1;22(5):371-6. https://doi.org/10.1002/ffj.1808
Go to original source...
- Koukoulitsa C, Karioti A, Bergonzi MC, et al. Polar constituents from the aerial parts of Origanum vulgare L. ssp. hirtum growing wild in Greece. Journal of agricultural and food chemistry. 2006 Jul 26;54(15):5388-92.
Go to original source...
- De Falco E, Mancini E, Roscigno G, et al. Chemical composition and biological activity of essential oils of Origanum vulgare L. subsp. vulgare L. under different growth conditions. Molecules. 2013 Dec 4;18(12):14948-60. https://doi.org/10.3390/molecules181214948
Go to original source...
Go to PubMed...
- Grboviæ F, Stankoviæ MS, Æurèiæ M, et al. In vitro cytotoxic activity of Origanum vulgare L. on HCT-116 and MDA-MB-231 cell lines. Plants. 2013;2(3):371-378.
Go to original source...
Go to PubMed...
- Lukas B, Schmiderer C, Mitteregger U, et al. Arbutin in marjoram and Oregano. Food Chemistry. 2010 Jul 1;121(1):185-90. https://doi.org/10.1016/j.foodchem.2009.12.028.
Go to original source...
- Force M, Sparks WS, Ronzio RA. Inhibition of enteric parasites by emulsified oil of Oregano in vivo. Phytotherapy Research. 2000 May;14(3):213-4. https://doi.org/10.1002/(SICI)1099-1573(200005)14:3
Go to original source...
Go to PubMed...
- Jerkoviæ I, Masteliæ J, Milo¹ M. The impact of both the season of collection and drying on the volatile constituents of Origanum vulgare L. ssp. hirtum grown wild in Croatia. International journal of food science & technology. 2001 Aug 1;36(6):649-54. https://doi.org/10.1046/j.1365-2621.2001.00502.x
Go to original source...
- Kikuzaki H, Nakatani N. Structure of a new antioxidative phenolic acid from (Origanum vulgare L.). Agricultural and Biological Chemistry. 1989 Feb 1;53(2):519-24. https://doi.org/10.1080/00021369.1989.10869290
Go to original source...
- Alkam T, Nitta A, Mizoguchi H, et al. A natural scavenger of peroxynitrites, rosmarinic acid, protects against impairment of memory induced by Aβ25-35. Behavioural brain research. 2007 Jun 18;180(2):139-45. https://doi.org/10.1016/j.bbr.2007.03.001
Go to original source...
Go to PubMed...
- Koukoulitsa C, Karioti A, Bergonzi MC, et al. Polar constituents from the aerial parts of Origanum vulgare L. ssp. hirtum growing wild in Greece. Journal of agricultural and food chemistry. 2006 Jul 26;54(15):5388-92.. https://doi.org/10.1021/jf061477i
Go to original source...
- Lombrea A, Antal D, Ardelean F, et al. A recent insight regarding the phytochemistry and bioactivity of Origanum vulgare L. essential oil. International Journal of Molecular Sciences. 2020 Jan;21(24):9653. https://doi.org/10.3390/ijms21249653
Go to original source...
Go to PubMed...
- Soltani S, Shakeri A, Iranshahi M, Boozari M. A Review of the Phytochemistry and Antimicrobial Properties of Origanum vulgare L. and Subspecies. Iranian journal of pharmaceutical research: IJPR. 2021;20(2):268. https://doi.org/10.22037/ijpr.2020.113874.14539
Go to original source...
Go to PubMed...
- Kaul VK, Singh B, Sood RP. Essential oil of Origanum vulgare L. from North India. Journal of Essential Oil Research. 1996 Jan 1;8(1):101-3https://doi.org/10.1080/10412905.1996.9700567
Go to original source...
- Vagi E, Rapavi E, Hadolin M, et al. Phenolic and triterpenoid antioxidants from Origanum majorana L. herb and extracts obtained with different solvents. Journal of agricultural and food chemistry. 2005 Jan 12;53(1):17-21. https://doi.org/10.1021/jf048777p
Go to original source...
Go to PubMed...
- Sezik E, Tümen G, Kirimer N, et al. Essential noil composition of four Origanum vulgare subspecies of Anatolian origin. Journal of Essential Oil Research. 1993 Jul 1;5(4):425-31. https://doi.org/10.1080/10412905.1993.9698253
Go to original source...
- Nowak R, Wójciak-Kosior M, Sowa I, et al. HPTLC densitometry determination of triterpenic acids in Origanum vulgare, Rosmarinus officinalis and Syzygium aromaticum. Acta poloniae pharmaceutica. 2013;70(3):413-8.
Go to PubMed...
- Picq M, Cheav SL, Prigent AF. Effect of two flavonoid compounds on central nervous system. Analgesic activity. Life sciences. 1991 Jan 1;49(26):1979-88. https://doi.org/10.1016/0024-3205(91)90640-W
Go to original source...
Go to PubMed...
- Koldaº S, Demirtas I, Ozen T, et al. Phytochemical screening, anticancer and antioxidant activities of Origanum vulgare L. ssp. viride (Boiss.) Hayek, a plant of traditional usage. Journal of the science of food and agriculture. 2015 Mar 15;95(4):786-98. https://doi.org/10.1002/jsfa.6903
Go to original source...
Go to PubMed...
- Chalchat JC, Pasquier B. Morphological and chemical studies of Origanum clones: Origanum vulgare L. ssp. vulgare. Journal of Essential Oil Research. 1998 Mar 1;10(2):119-25. https://doi.org/10.1080/10412905.1998.9700861
Go to original source...
- Trinchieri G. Cancer and inflammation: an old intuition with rapidly evolving new concepts. Annual review of immunology. 2012 Apr 23;30:677-706. 10.1146/annurev-immunol-020711-075008
Go to original source...
Go to PubMed...
- Javadian S, Sabouni F, Haghbeen K. Origanum Vulgare L. Extracts Versus Thymol: An Anti-Inflammatory Study on Activated Microglial and Mixed Glial Cells. Journal of food biochemistry. 2016 Feb 1;40(1):100-8. https://doi.org/10.1111/jfbc.12199
Go to original source...
- Mir RH, Sawhney G, Verma R, et al. Origanum vulgare L.: In vitro Assessment of Cytotoxicity, Molecular Docking Studies, Antioxidant and Anti-inflammatory Activity in LPS Stimulated RAW 264.7 Cells. Medicinal Chemistry. 2021 Nov 1;17(9):983-93. https://doi.org/10.2174/1573406416666200904110828
Go to original source...
Go to PubMed...
- Han X, Parker TL. Anti-inflammatory, tissue remodeling, immunomodulatory, and anticancer activities of Oregano (Origanum vulgare) essential oil in a human skin disease model. Biochimie Open. 2017 Jun 1;4:73-7. https://doi.org/10.1016/j.biopen.2017.02.005
Go to original source...
Go to PubMed...
- Conforti F, Marrelli M, Menichini F, et al. Chemical composition and protective effect of Oregano (Origanum heracleoticum L.) ethanolic extract on oxidative damage and on inhibition of NO in LPS-stimulated RAW 264.7 macrophages. Journal of Enzyme Inhibition and Medicinal Chemistry. 2011 Jun 1;26(3):404-11. https://doi.org/10.3109/14756366.2010.519336
Go to original source...
Go to PubMed...
- Leyva-López N, Nair V, Bang WY, et al. Protective role of terpenes and polyphenols from three species of Oregano (Lippia graveolens, Lippia palmeri and Hedeoma patens) on the suppression of lipopolysaccharide-induced inflammation in RAW 264.7 macrophage cells. Journal of Ethnopharmacology. 2016 Jul 1;187:302-12. https://doi.org/10.1016/j.jep.2016.04.051
Go to original source...
Go to PubMed...
- Siti HN, Kamisah Y, Kamsiah JJ. The role of oxidative stress, antioxidants and vascular inflammation in cardiovascular disease (a review). Vascular pharmacology. 2015 Aug 1;71:40-56. https://doi.org/10.1016/j.vph.2015.03.005
Go to original source...
Go to PubMed...
- Teixeira B, Marques A, Ramos C, Serrano C, Matos O, Neng NR, Nogueira JM, Saraiva JA, Nunes ML. Chemical composition and bioactivity of different Oregano (Origanum vulgare) extracts and essential oil. Journal of the Science of Food and Agriculture. 2013 Aug 30;93(11):2707-14. https://doi.org/10.1002/jsfa.6089
Go to original source...
Go to PubMed...
- Arana-Sánchez A, Estarrón-Espinosa M, Obledo-Vázquez EN, et al. Antimicrobial and antioxidant activities of Mexican Oregano essential oils (Lippia graveolens HBK) with different composition when microencapsulated inβ-cyclodextrin. Letters in Applied Microbiology. 2010 Jun;50(6):585-90. https://doi.org/10.1111/j.1472-765X.2010.02837.x
Go to original source...
Go to PubMed...
- Babili FE, Bouajila J, Souchard JP, et al. Oregano: chemical analysis and evaluation of its antimalarial, antioxidant, and cytotoxic activities. Journal of food science. 2011 Apr;76(3): C512-8. https://doi.org/10.1111/j.1750-3841.2011.02109.x
Go to original source...
Go to PubMed...
- Marrelli M, Conforti F, Formisano C, et al. Composition, antibacterial, antioxidant and antiproliferative activities of essential oils from three Origanum species growing wild in Lebanon and Greece. Natural product research. 2016 Mar 18;30(6):735-9. https://doi.org/10.1080/14786419.2015.1040993
Go to original source...
Go to PubMed...
- Boroski M, Giroux HJ, Sabik H, et al. Use of Oregano extract and Oregano essential oil as antioxidants in functional dairy beverage formulations. LWT-Food Science and Technology. 2012 Jun 1;47(1):167-74. https://doi.org/10.1016/j.lwt.2011.12.018.
Go to original source...
- Tuttolomondo T, La Bella S, Licata M, et al. Biomolecular characterization of wild sicilian Oregano: Phytochemical screening of essential oils and extracts, and evaluation of their antioxidant activities. Chemistry & biodiversity. 2013 Mar;10(3):411-33. https://doi.org/10.1002/cbdv.201200219
Go to original source...
Go to PubMed...
- Adam K, Sivropoulou A, Kokkini S, et al. Antifungal activities of Origanum vulgare subsp. hirtum, Mentha spicata, Lavandula angustifolia, and Salvia fruticose essential oils against human pathogenic fungi. Journal of Agricultural and Food Chemistry. 1998 May 18;46(5):1739-45. https://doi.org/10.1021/jf9708296
Go to original source...
- Aguilar-Pérez KM, Medina DI, Narayanan J, et al. Synthesis and nano-sized characterization of bioactive Oregano essential oil molecule-loaded small unilamellar nanoliposomes with antifungal potentialities. Molecules. 2021 Jan;26(10):2880. https://doi.org/10.3390/molecules26102880
Go to original source...
Go to PubMed...
- Herrera-Rodríguez SE, López-Rivera RJ, García-Márquez E, et al. Mexican Oregano (Lippia graveolens) essential oil-in-water emulsions: impact of emulsifier type on the antifungal activity of Candida albicans. Food science and biotechnology. 2019 Apr;28(2):441-8. https://doi.org/10.1007/s10068-018-0499-6
Go to original source...
Go to PubMed...
- Lemhadri A, Zeggwagh NA, Maghrani M, et al. Anti-hyperglycaemic activity of the aqueous extract of Origanum vulgare growing wild in Tafilalet region. Journal of ethnopharmacology. 2004 Jun 1;92(2-3):251-6. https://doi.org/10.1016/j.jep.2004.02.026
Go to original source...
Go to PubMed...
- Sarikurkcu C, Zengin G, Oskay M, et al. Composition, antioxidant, antimicrobial and enzyme inhibition activities of two Origanum vulgare subspecies (subsp. vulgare and subsp. hirtum) essential oils. Industrial Crops and Products. 2015 Aug 1;70:178-84. https://doi.org/10.1016/j.indcrop.2015.03.030
Go to original source...
- Alef B, Abdennacer B, Mohamed B. A-amylase inhibitory activities of Origanum glandolosum, a North African endemic species. Int. J. Adv. Res. 2013;1:25-32.
- Sharifi-Rad J, Sureda A, Tenore GC, et al. Biological activities of essential oils: From plant chemoecology to traditional healing systems. Molecules. 2017 Jan;22(1):70. https://doi.org/10.3390/molecules22010070
Go to original source...
Go to PubMed...
- Kubatka P, Kello M, Kajo K, et al. Oregano demonstrates distinct tumour-suppressive effects in the breast carcinoma model. European journal of nutrition. 2017 Apr 1;56(3):1303-16. https://doi.org/10.1007/s00394-016-1181-5
Go to original source...
Go to PubMed...
- Misharina TA, Burlakova EB, Fatkullina LD, et al. Effect of essential oil on the engraftment and development of Lewis carcinoma in F1 DBA C57 black hybrid mice. Applied biochemistry and microbiology. 2013 Jul;49(4):432-6.https://doi.org/10.1134/S0003683813040091
Go to original source...
- Hussain AI, Anwar F, Rasheed S, et al. Composition, antioxidant and chemotherapeutic properties of the essential oils from two Origanum species growing in Pakistan. Revista Brasileira de Farmacognosia. 2011 Dec;21(6):943-52.
Go to original source...
- Adame-Gallegos JR, Andrade-Ochoa S, Nevarez-Moorillon GV. Potential use of Mexican Oregano essential oil against parasite, fungal and bacterial pathogens. Journal of Essential Oil Bearing Plants. 2016 Apr 2;19(3):553-67. https://doi.org/10.1080/0972060X.2015.1116413
Go to original source...
- Oniga I, Pușcaș C, Silaghi-Dumitrescu R, et al. Origanum vulgare ssp. vulgare: Chemical composition and biological studies. Molecules. 2018;23(8):2077. https://doi.org/10.3390/molecules23082077
Go to original source...
Go to PubMed...
- Chun SS, Vattem DA, Lin YT et al. Phenolic antioxidants from clonal Oregano (Origanum vulgare) with antimicrobial activity against Helicobacter pylori. Process Biochemistry. 2005;40(2):809-816. https://doi.org/10.1016/j.procbio.2004.02.018
Go to original source...
- Mombeini T, Mazloumi S, Shams J. Pharmacological Effects of Origanum Vulgare L. in the Elevated Plus-Maze and Open Field Tests in the Rat. Journal of Basic and Clinical Pathophysiology. 2015 Sep 10;3(2):29-36. https://doi.org/10.22070/jbcp.2015.229
Go to original source...
- Bautista-Hernández I, Aguilar CN, Martínez-Ávila GC, et al. Mexican Oregano (Lippia graveolens Kunth) as Source of Bioactive Compounds: A Review. Molecules. 2021 Jan;26(17):5156. https://doi.org/10.3390/molecules26175156
Go to original source...
Go to PubMed...
- Amiresmaeili A, Roohollahi S, Mostafavi A, et al. Effects of Oregano essential oil on brain TLR4 and TLR2 gene expression and depressive-like behavior in a rat model. Research in pharmaceutical sciences. 2018 Apr;13(2):130. https://doi.org/10.4103/1735-5362.223795
Go to original source...
Go to PubMed...
- Afarineshe MK, Pahlavan Y, Sepehri GH, et al. Antinociceptive Effect of Aqueous Extract of Origanum vulgare L. in Male Rats: Possible Involvement of the GABAergic System. Iranian journal of pharmaceutical research: IJPR. 2013;12(2):407-13.
Go to PubMed...
- Costa TK, Barros MS, Braga RM, et al. Orofacial antinociceptive activity and anchorage molecular mechanism in silico of geraniol. Brazilian Oral Research. 2020 Aug 7;34. https://doi.org/10.1590/1807-3107bor-2020.vol34.0094
Go to original source...
Go to PubMed...
- Chabib L, Suryani A, Pangestu MI, et al. IAI CONFERENCE: The development of Origanum vulgare L. into nanoparticles in dosage forms. Pharmacy Education. 2021 Jul 28;21(2):205-9. https://doi.org/10.46542/pe.2021.212.205209
Go to original source...
- Khan A, Bashir S, Khan SR, et al. Antiurolithic activity of Origanum vulgare is mediated through multiple pathways. BMC complementary and alternative medicine.2011 Dec;11(1):96. https://doi.org/10.1186/1472-6882-11-96
Go to original source...
Go to PubMed...
- ElSawy NA, Mosa OF. The antiurolithic activity of Origanum vulgare on rats treated with ethylene glycol and ammonium chloride: Possible pharmaco-biochemical and ultrastructure effects. Current Urology. 2021 Jun;15(2):119. https://doi.org/10.1097/CU9.0000000000000017
Go to original source...
Go to PubMed...
- Sikander M, Malik S, Parveen K, et al. Hepatoprotective effect of Origanum vulgare in Wistar rats against carbon tetrachloride-induced hepatotoxicity. Protoplasma. 2013 Apr 1;250(2):483-93. https://doi.org/10.1007/s00709-012-0431-5
Go to original source...
Go to PubMed...
- Abdel-Latif HM, Abdel-Tawwab M, Khafaga AF, et al. Dietary Oregano essential oil improved the growth performance via enhancing the intestinal morphometry and hepato-renal functions of common carp (Cyprinus carpio L.) fingerlings. Aquaculture. 2020 Sep 15;526:735432. https://doi.org/10.1016/j.aquaculture.2020.735432
Go to original source...
- El-sayed M, Elkomy A, Farag E, et al. Hepatoprotective effect of organium majorana against albendazole-induced hepatotoxicity in rats. Benha Veterinary Medical Journal. 2021 Oct 1;41(1):148-53. https://doi.org/10.21608/bvmj.2021.72813.1396
Go to original source...
- Abbasnejad M, Mirtajadini M, Afarinesh MR, et al. Valuation of Origanum vulgare (leaves, stems and flowers) extract on spatial learning in male rats. Physiology and Pharmacology. 2006 Mar 10;10(2):143-50. https://iranjournals.nlai.ir/handle/123456789/511813
- Mohajeri MH, Prudence K. Animal and human efficacy data of a brain active Oregano extract. AGRO FOOD INDUSTRY HI-TECH. 2013 Jul 1;24(4):16-9.
- Wavra N. Bring on the Spice: Spices do more than just enhance flavor, they also can have a big impact on health. Read on to learn more. Environmental Nutrition. 2019 Jan 1;42(1):3-4.
- Liang CH, Chou TH, Ding HY. Inhibition of melanogenesis by a novel origanoside from Origanum vulgare. Journal of dermatological science. 2010 Mar 1;57(3):170-7. https://doi.org/10.1016/j.jdermsci.2009.12.009
Go to original source...
Go to PubMed...
- Morshedloo MR, Pirali Hamedani M, Yazdani D. An over review to Origanum vulgare L. and its pharmacological properties. Journal of Medicinal Plants. 2018 Dec 10;17(68):15-31.
- Nanni V, Di Marco G, Sacchetti G, et al. Oregano phytocomplex induces programmed cell death in melanoma lines via mitochondria and DNA damage. Foods. 2020 Oct;9(10):1486. https://doi.org/10.3390/foods9101486
Go to original source...
Go to PubMed...
- Veenstra JP and Johnson JJ. Oregano (Origanum vulgare) extract for food preservation and improvement in gastrointestinal health. International journal of nutrition. 2019;3(4):43. https://doi.org/10.14302/issn.2379-7835.ijn-19-2703
Go to original source...
Go to PubMed...
- Feng J, Lu M, Wang J, et al. Dietary Oregano essential oil supplementation improves intestinal functions and alters gut microbiota in late-phase laying hens. Journal of Animal Science and Biotechnology. 2021 Dec;12(1):1-5. https://doi.org/10.1186/s40104-021-00600-3
Go to original source...
Go to PubMed...
- Paderes NM and Lagangilang AP. Antiangiogenic Activity of Oregano (Origanum Vulgare) Aqueous Extract In-Vivo Through Chick Chorioallantoic Membrane (Cam) Assay. Systematic Reviews in Pharmacy. 2020;11(6):1222-1227.
- Bostancioğlu RB, Kürkçüoğlu M, Baºer KH, et al. Assessment of anti-angiogenic and anti-tumoral potentials of Origanum onites L. essential oil. Food and Chemical Toxicology. 2012 Jun 1;50(6):2002-8. https://doi.org/10.1016/j.fct.2012.03.074
Go to original source...
Go to PubMed...