MMSL, 2018 (vol. 87), issue 2
THE EVIDENCE OF ANNUAL OCCURRENCE OF VARICELLA ZOSTER VIRUS (VZV) IN TEMPER CLIMATE OF CZECH REPUBLICOriginal article
Vanda Boštíková, Miloslav Salavec, Radek Sleha, Pavel Blažek, Sylva Janovská, Petr Prášil, Stanislav Plíšek, Pavel Kosina, Pavel Boštík
MMSL 2018, 87(2):50-60 | DOI: 10.31482/mmsl.2018.011 
Study objectives: Varicella is a highly infectious disease, which is, however, preventable and an effective vaccine is available. Samples from a cohort of ambulatory and hospitalized patients (Faculty Hospital Hradec Králové) were analyzed as part of our molecular genetic study of varicella-zoster virus during years 2009 – 2016.Materials and methods: Altogether, 463 persons with varicella were younger than 18 years and 160 persons (25,7 %) were older. A total of 18 patients (2,9 %) were immunocompromised. Fifty patients reported the second incidence and 1 patient even third incidence of varicella.Results: Patients reported with varicella during...
SURGICAL TREATMENT OF GASTRIC ADENOCARCINOMA: TOTAL VS. SUBTOTAL GASTRECTOMY. A SINGLE CENTRE EXPERIENCEOriginal article
Kateřina Vinklerová, Radomír Hyšpler, Jiří Páral, Petr Lochman
MMSL 2018, 87(2):61-67 | DOI: 10.31482/mmsl.2018.013
The purpose of this study is to analyze postoperative morbidity and mortality of patients undergoing various types of gastric resection for adenocarcinoma in a single centre and to evaluate the oncological outcome regarding to completeness of resection.Ninety-eight patients with gastric adenocarcinoma were involved in the present study. We observed postoperative complications or death and a length of hospital stay, completeness of resection, TNM staging. Differences in overall survival between total (TG) and subtotal gastrectomy (SG) were analyzed using analysis of variance (ANOVA) and Kruskal-Wallis test with p < 0,05 value.There was no statistically...
SUMMARRY OF THE SWISS VACCINATION SYSTEMReview article
František Saňák
MMSL 2018, 87(2):68-73 | DOI: 10.31482/mmsl.2018.017
Vaccination protects the community as a whole from serious communicable diseases, such as polio, pertussis, diphteria, measles and others. The incidence of these diseases has been successfully reduced in the last decades. Switzerland with its National vaccination strategy takes part in an international effort on public health described in WHO’s 2011-2020 Global Vaccine Action Plan (1), and in the European 2015 - 2020 Vaccine Action Plan (2). However, in contrast to the Czech Republic, Switzerland doesn´t have a compulsory global vaccination schedule. It only presents the vaccination recommendations. Vaccination rates are not always high...
DIAGNOSIS OF AUTOIMMUNE DISEASESReview article
Adam Kostelník, Miroslav Pohanka
MMSL 2018, 87(2):74-81 | DOI: 10.31482/mmsl.2018.010
Autoimmune diseases are caused by reaction of immune system against own body´s healthy structures. Diagnostics of these states require collaboration between clinical and laboratory diagnostic part. This text is focusing on diagnostics selected systemic and organ specific autoimmune diseases. It does not aim for detail description of selected diseases rather summarizing the main clues leading to right diagnostics. Also suggesting laboratory methods used in diagnostics and summarizing their benefits and drawbacks.
CHITOSAN - PROTOTYPE POLYMER NANOPARTICLES WITH TRANSPORT CAPACITYReview article
Klára Kubelková, Simona Frydrychová, Jaroslav Pejchal
MMSL 2018, 87(2):82-91 | DOI: 10.31482/mmsl.2018.014
Chitosan is low toxic, non-immunogenic and biodegradable natural biopolymer. As the deacetylated form of chitin, it is extensively used in medicine, agriculture and industry for easy production, biocompatibility and antimicrobial activity. Chitosan is also widely studied as the main structural unit of nanomaterials. Numerous studies have shown the strong antimicrobial activity of chitosan including its efficacy as an adjuvant for construction of new vaccines. In this overview, we present the basic information on chitosan nanopar-ticles, their preparation, purification, and characterization as well as the new data on their utilization for the construction...
NOVICHOK AGENTS - MYSTERIOUS POISONOUS SUBSTANCES FROM THE COLD WAR PERIODReview
Jiří Patočka
MMSL 2018, 87(2):92-94 | DOI: 10.31482/mmsl.2018.012
On March 4, Sergei Skripal, a former Russian spy who was convicted and imprisoned in Russia for working as a double agent, and his daughter were found unresponsive and slumped on a shopping-center bench in Salisbury, England. On 12 March 2018, British Prime Minister Theresa May said in Parliament that the two had been poisoned with Novichok, a “military grade” nerve agent developed by Russia, and she moved swiftly to retaliate against the government of President Vladimir Putin (BBC News, 12 March 2018). It was the first use of a nerve agent on European soil since World War II. Russian authorities have rejected May’s claims as nonsense....
HOST PATHOGEN INTERACTION FORUM HAS ACHIEVED INTERNATIONAL RECOGNITIONLetter to the editor
Klára Kubelková
MMSL 2018, 87(2):95-97
The 13th Host Pathogen Interaction Forum was held in Slavonice, Czech Republic, between April 16 and April 19, 2018. The Forum is traditionally organized by the Faculty of Military Health Sciences, Hradec Králové, Czech Republic, in collaboration with the Czech Immunological Society in Prague, Czech Republic. The venues for our Forums are selected with respect to historically significant areas of the Czech Republic. The Forum’s reputation has grown steadily over the years such that it has earned a place on the calendars of important scientists in the field of studies on pathogen interactions with their hosts. Due to the scientific...
13th INTERNATIONAL MEETING ON CHOLINESTERASES, 7th INTERNATIONAL CONFERENCE ON PARAOXONASESAnnouncement
Ondřej Soukup
MMSL 2018, 87(2):98
Dear Colleagues, Dear Friends I am honored to announce that the 13th International Meeting on Cholinesterases and the 7th International Conference on Paraoxonases will be organised under my supervision in the Czech Republic: 9th to 14th of September 2018 Hradec Králové, Czech Republic We would like to gather all researchers around the globe with a focus on cholinesterases, paraoxonases and also phosphotriesterases and I feel privileged to follow up the meeting in Elche in 2015 and further extend the great tradition of cholinesterase meetings dated since 1975. Dear friends, please accept my cordial...
COLONEL (ret.) Professor PAVEL KUNA, MD, DrSc. PASSED AWAY. (1. 11. 1940 – 17. 4. 2018)Letter to the editor
Jiřina Vávrová
MMSL 2018, 87(2):99-100
On April 17, 2018, Colonel (ret.) Professor Pavel Kuna, MD, DrSc., an important representative of Czechoslovak radiobiology and military university education, passed away. He was highly respected for his deep theoretical and professional knowledge, sensitive orientation in main directions of the development within a relatively new medical discipline. He was always a hard-working researcher and, at the same time, an exacting but favourite teacher.