MMSL, 2020 (vol. 89), issue 2
BATS - A PANDORA'S BOX FOR VIRUSES IN THE 21st CENTURYReview article
Vanda Boštíková
MMSL 2020, 89(2):58-65 | DOI: 10.31482/mmsl.2020.012 
More attention has been paid to bat research in recent years, resulting in the detection of viruses similar to those that cause serious infectious diseases in both humans and other mammals. The ability to fly, among other atypical characteristics, probably influenced their antiviral immune response during evolution. They can control the propagation of the virus and limit self-damaging inflammatory processes. The study of these properties is very important for understanding and possible prediction of virus jump to new hosts.
SEARCHING FOR NEW ANTIMICROBIAL AGENTS BY TARGETING BACTERIAL NAD METABOLISM: EVALUATION OF FRENTIZOLE DERIVATIVES SELECTED BY MOLECULAR DOCKINGOriginal article
Michaela Hympanova, Tomas Kucera, Ondrej Benek, Jan Korabecny, Jan Marek
MMSL 2020, 89(2):66-73 | DOI: 10.31482/mmsl.2020.005
Growing evidence of antibiotic-resistant pathogens is a serious medical issue that has to be addressed. Our antimicrobial research is focused on searching for novel small molecules that differ from the most clinically used antibiotics by chemical structure and mechanism. However, this fundamental research is like looking for a needle in a haystack. In addition, in vitro methods are time-consuming and expensive to screen large number of compounds in reasonable time. Off-target screening can represent a solution to find novel and effective antimicrobial agents that can eliminate these problems. Accordingly, molecular docking in the family of selected...
TELEMEDICINE AND OBESITY TREATMENTReview article
Miroslav Urban, Ondřej Kádě, Vladimír Pavlík, Václav Šafka, Petr Lašák, Lucie Pravdová, Martin Matoulek
MMSL 2020, 89(2):74-79 | DOI: 10.31482/mmsl.2020.007
The telemedicine shows rapid development in the past decades of 20th century. It’s principally based on the transmission of sound, pictures and other kind of data using wireless technology. The establishing of the telemedicine in the obezitology begins at die end of 20th century. That time shows the technique a rapidly development, but even more, there were first menus made and shared trough the PCs. All the mend facts are connected due to rapidly increased amount of the people with obesity. In the Czech Republic, approximately 60 % of the adult population suffer obesity or overweight. The telemedicine would applied specially for the cases as...
INFLUENCE OF IONIZING RADIATION ON DEVELOPMENT OF THYMUS AND THYMOCYTESReview article
Markéta Němcová, Anna Lierová, Lenka Andrejsová, Marcela Jeličová, Zuzana Šinkorová
MMSL 2020, 89(2):80-89 | DOI: 10.31482/mmsl.2019.022
Purpose: Among other reasons, the deteriorating global security situation and dangers associated with nuclear weapons have increased the need for deeper knowledge of the basic mechanisms involving the human immune system and ionizing radiation (IR). We conducted a review as to the effects of IR on thymic tissue, and particularly on the development of thymocytes and the T lymphocytes population in peripheral blood.Existing knowledge on this topic is based in part on national registers that store records concerning irradiated people. The majority of studies in this area, however, are based on experimental animal models. The main open question in this...
CYNOMORIUM PLANTS: BIOACTIVE COMPOUNDS AND PHARMACOLOGIC ACTIONSReview article
Jiří Patočka, Zdeňka Navrátilová
MMSL 2020, 89(2):90-98 | DOI: 10.31482/mmsl.2020.001
Cynomorium coccineum and Cynomorium songaricum are unusual parasitic plants in the family Cynomoriaceae characterized by their unusual appearance and way of life. Due to their special habit and extremely rare occurrence, in the past, various magical properties have been attributed to these plants. The plant Cynomorium coccineum, which is found in the Mediterranean, has been used in Europe since the Middle Ages in folk medicine under the name fungus maletensis (maltese fungus). It was used for the same purpose in Arabic cultures under the name tarthuth. The Asian species (Cynomorium songaricum), sometimes considered...
DEFINITION OF THE TARGET POPULATION FOR EXTERNAL PACEMAKER AS A KEY ASPECT IN SUCCESSFUL MEDICAL DEVICE HTA PROCESSReview article
Jan Honegr, Daniel Jun, Kamil Kuca, Petra Maresova
MMSL 2020, 89(2):99-107 | DOI: 10.31482/mmsl.2020.003
In this paper we have compiled and summarized the steps which manufacturers and clinical investigators need to undertake to perform a target population definition during the Health technology assessment process of medical device, namely external cardio stimulator (pacemaker). Based on available data using top-down approach we have defined target population for external cardiostimulator and estimated, that the size of the target population for external pacing will not exceed 16000 patients per year in the Czech Republic and is of comparable size with other states in the region.
LUXATION OF THE KNEE JOINT COMPLICATED BY THE INJURY OF THE POPLITEAL ARTERYCase report
Karel Šmejkal, Jan Šimek, Tomáš Dědek, Jiří Páral
MMSL 2020, 89(2):108-112 | DOI: 10.31482/mmsl.2020.004
Luxation of the knee joint is a relatively rare high-energy injury with a disability of all knee joints with many early and late complications. While the diagnosis itself does not make it difficult, complications such as lesion of popliteal artery or compartment syndrome are key points and can escape attention and are needed to be actively pursued. One such case of knee luxation with revascularization by popliteopopliteal bypass using the autologous graft v. Saphena magna and thrombectomy of the leg arteries and protective fasciotomy for impending compartment syndrome is presented by the authors in this case study.