MMSL 2018, 87(2):82-91 | DOI: 10.31482/mmsl.2018.014

CHITOSAN - PROTOTYPE POLYMER NANOPARTICLES WITH TRANSPORT CAPACITYReview article

Klára Kubelková ORCID...1*, Simona Frydrychová2, Jaroslav Pejchal ORCID...3
1 Katedra molekulární patologie a biologie, Fakulta vojenského zdravotnictví, Univerzita Obrany, Hradec Králové
2 Katedra epidemiologie, Fakulta vojenského zdravotnictví, Univerzita Obrany, Hradec Králové
3 Katedra toxikologie a vojenské farmacie, Fakulta vojenského zdravotnictví, Univerzita Obrany, Hradec Králové

Chitosan je málo toxický, neimunogenní a biologicky odbouratelný přírodní biopolymer. Jako deacetylovaná forma chitinu je ve velké míře používán v medicíně, zemědělství a průmyslu kvůli snadné výrobě, biokompatibilitě a antimikrobiální aktivitě. Chitosan je také široce studován jako hlavní stavební složka nanomateriálů. Četné studie prokázaly, že chitosan, kromě silných antibakteriálních účinků, lze využít jako adjuvans při konstrukci nových vakcín. Neméně významné je potenciální využití chitosanu jako nosiče xenobiotik. V tomto přehledu uvádíme základní informace o chitosanových nanočásticích, jejich přípravě, purifikaci a charakterizaci, stejně tak nová data o možnosti jejich využití pro přípravu směrovaných léčiv na bázi nanotechnologií.

Keywords: chitosan; chitin; nanočástice; vakcinace; nanotechnologie

Chitosan is low toxic, non-immunogenic and biodegradable natural biopolymer. As the deacetylated form of chitin, it is extensively used in medicine, agriculture and industry for easy production, biocompatibility and antimicrobial activity. Chitosan is also widely studied as the main structural unit of nanomaterials. Numerous studies have shown the strong antimicrobial activity of chitosan including its efficacy as an adjuvant for construction of new vaccines. In this overview, we present the basic information on chitosan nanopar-ticles, their preparation, purification, and  characterization as well as the new data on their utilization for the construction of targetted drugs based on nanotechnologies.

Keywords: chitosan; chitin; nanoparticules; vaccination; nanotechnology

Received: January 17, 2018; Revised: April 4, 2018; Prepublished online: April 24, 2018; Published: June 8, 2018  Show citation

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Kubelková, K., Frydrychová, S., & Pejchal, J. (2018). CHITOSAN - PROTOTYPE POLYMER NANOPARTICLES WITH TRANSPORT CAPACITY. MMSL, 87(2), 82-91. doi: 10.31482/mmsl.2018.014
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