MMSL 2023, 92(1):75-86 | DOI: 10.31482/mmsl.2022.026

PROPOLIS-INDUCED HEPATORENOPROTECTION IN RODENTS EXPOSED TO RIFAMPICIN AND ISONIAZIDOriginal article

Ahmed Abdulsallam ORCID...1*, Imad A. Thanoon ORCID...2, Abdulrahman I. Abduljabbar ORCID...3
1 Alkhansaa Teaching hospital, Mosul, Ninevah Province, Iraq
2 College of Medicine, University of Mosul, Mosul, Ninevah Province, Iraq
3 Graduated Physician, University of Mosul, Mosul, Ninevah Province, Iraq

The elimination of most drugs based on liver/renal excretion; making liver and kidneys the commonest target organ for exposure to toxic materials. Long-term use of drugs surpassed the effect and aggravate the toxicity. Tuberculosis (TB) is chronic disease with long-term therapy and the deleterious impact of antitubelculosis is certain. Various pharmacokinetic manoveuors were proposed to avoid the potential harmful effect of TB therapy. The present study aimed at mitigating the destructive effects of TB therapy using propolis. To do so, rats were exposed to isoniazid or rifampicin or a combination of them in groups of 8 rats each for a period of 8-weeks these groups were matched with similar group with a propolis ad-on therapy. These results were compared to propolis-free negative control group and positive propolis-treated group. The histological and laboratory findings confirmed that isoniazid or rifampicin or a combination of them jeopardized hepatorenal function and induced deleterious damage. However, isoniazid has shown more intensive deleterious effect compared to rifampicin. Nonetheless, propolis restore the quasi-equilibrium status for kidney and liver via restoring its normal architecture and functionality. To sum up, the potential defect of anti-TB was restored via using propolis as add-on therapy, we do advise using propolis as an adjuvant TB therapy in critically–ill and clinical cases required long-term TB therapy.

Keywords: isoniazid; rifampicin; propolis; liver; kidney

Received: March 29, 2022; Revised: May 25, 2022; Accepted: July 12, 2022; Prepublished online: July 28, 2022; Published: March 3, 2023  Show citation

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Abdulsallam, A., Thanoon, I.A., & Abduljabbar, A.I. (2023). PROPOLIS-INDUCED HEPATORENOPROTECTION IN RODENTS EXPOSED TO RIFAMPICIN AND ISONIAZID. MMSL92(1), 75-86. doi: 10.31482/mmsl.2022.026
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References

  1. Hasan SK, Khan R, Ali N, et al. 18-β Glycyrrhetinic acid alleviates 2-acetylaminofluorene-induced hepatotoxicity in Wistar rats: role in hyperproliferation, inflammation and oxidative stress. Human & Experimental Toxicology. 2015 Jun;34(6):628-41. https://doi.org/10.1177/0960327114554045 Go to original source... Go to PubMed...
  2. Zakaria ZA, Mahmood ND, Mamat SS, et al. Endogenous antioxidant and LOX-mediated systems contribute to the hepatoprotective activity of aqueous partition of methanol extract of Muntingia calabura L. leaves against paracetamol intoxication. Frontiers in pharmacology. 2018 Feb 15;8:982. https://doi.org/10.3389/fphar.2017.00982 Go to original source... Go to PubMed...
  3. Ahmad SB, Rehman MU, Fatima B, et al. Antifibrotic effects of D-limonene (5 (1-methyl-4-[1-methylethenyl]) cyclohexane) in CCl4 induced liver toxicity in Wistar rats. Environmental toxicology. 2018 Mar;33(3):361-9. https://doi.org/10.1002/tox.22523 Go to original source... Go to PubMed...
  4. Costiniuk CT, McCarthy AE, Talreja H, et al. Acute renal failure and disseminated intravascular coagulation associated with rifampin in tuberculosis treatment [Correspondence]. The International Journal of Tuberculosis and Lung Disease. 2011 Mar 1;15(3):421.
  5. Beebe A, Seaworth B, Patil N. Rifampicin-induced nephrotoxicity in a tuberculosis patient. Journal of Clinical Tuberculosis and Other Mycobacterial Diseases. 2015 Nov 1;1:13-5. https://doi.org/10.1016/j.jctube.2015.09.001 Go to original source... Go to PubMed...
  6. Clarkson MR, Giblin L, O'Connell FP, et al. Acute interstitial nephritis: clinical features and response to corticosteroid therapy. Nephrology Dialysis Transplantation. 2004 Nov 1;19(11):2778-83. https://doi.org/10.1093/ndt/gfh485 Go to original source... Go to PubMed...
  7. Ramappa V, Aithal GP. Hepatotoxicity related to anti-tuberculosis drugs: mechanisms and management. Journal of clinical and experimental hepatology. 2013 Mar 1;3(1):37-49. https://doi.org/10.1016/j.jceh.2012.12.001 Go to original source... Go to PubMed...
  8. Tasduq SA, Kaiser P, Sharma SC, et al. Potentiation of isoniazid-induced liver toxicity by rifampicin in a combinational therapy of antitubercular drugs (rifampicin, isoniazid and pyrazinamide) in Wistar rats: A toxicity profile study. Hepatology Research. 2007 Oct;37(10):845-53. https://doi.org/10.1111/j.1872-034X.2007.00129.x Go to original source... Go to PubMed...
  9. Arbex MA, Varella MD, Siqueira HR, et al. Antituberculosis drugs: drug interactions, adverse effects, and use in special situations-part 1: first-line drugs. Jornal Brasileiro de Pneumologia. 2010;36:626-40. https://doi.org/10.1590/S1806-37132010000500016 Go to original source... Go to PubMed...
  10. Agal S, Baijal R, Pramanik S, et al. Monitoring and management of antituberculosis drug induced hepatotoxicity. Journal of Gastroenterology and Hepatology. 2005 Nov;20(11):1745-52. https://doi.org/10.1111/j.1440-1746.2005.04048.x Go to original source... Go to PubMed...
  11. Langenheim JH. Plant resins: chemistry, evolution, ecology, and ethnobotany. Oregon, US: Timber Press; 2003.
  12. Wali AF, Avula B, Ali Z, et al. Antioxidant, hepatoprotective potential and chemical profiling of propolis ethanolic extract from Kashmir Himalaya region using UHPLC-DAD-QToF-MS. BioMed research international. 2015 Oct 11;2015. https://doi.org/10.1155/2015/393462 Go to original source... Go to PubMed...
  13. Wali AF, Mushtaq A, Rehman MU, et al. In vitro antioxidant and antimicrobial activities of propolis from Kashmir Himalaya region. Free radicals and antioxidants. 2016;6(1):51-7. DOI: 10.5530/fra.2016.1.6 Go to original source...
  14. Silva-Carvalho R, Baltazar F, Almeida-Aguiar C. Propolis: a complex natural product with a plethora of biological activities that can be explored for drug development. Evidence-Based Complementary and Alternative Medicine. 2015 Jan 1;2015. https://doi.org/10.1155/2015/206439 Go to original source... Go to PubMed...
  15. Nna VU, Bakar AB, Mohamed M. Malaysian propolis, metformin and their combination, exert hepatoprotective effect in streptozotocin-induced diabetic rats. Life sciences. 2018 Oct 15;211:40-50. https://doi.org/10.1016/j.lfs.2018.09.018 Go to original source... Go to PubMed...
  16. Kocot J, Kie³czykowska M, Luchowska-Kocot D, et al. Antioxidant potential of propolis, bee pollen, and royal jelly: Possible medical application. Oxidative medicine and cellular longevity. 2018 May 2;2018. https://doi.org/10.1155/2018/7074209 Go to original source... Go to PubMed...
  17. Yang J, Ren J, Wang A. Isolation, characterization, and hepatoprotective activities of terpenes from the gum resin of Boswellia carterii Birdw. Phytochemistry Letters. 2018 Feb 1;23:73-7. https://doi.org/10.1016/j.phytol.2017.10.005 Go to original source...
  18. Faisal IM, Almukhtar HM, Merkhan MM, et al. Comparative anti-inflammatory effect of risperidone versus olanzapine in schizophrenic patients. Indian J. Publ. Health Res. Develop.. 2019 Aug 1;10(8):964-9. Go to original source...
  19. Abdulrazzaq G, Khalaf MM, Merkhan MM. Allopurinol therapy impairs lipid metabolism in patients with renal stone. Pharmacology. 2006;1:1.
  20. Faisal IM, Merkhan MM, Almukhtar HM. Effect of chronic Allopurinol therapy on Thyroid function in patients with urate stones. Journal of Advanced Pharmacy Education & Research| Oct-Dec. 2020;10(4):5.
  21. Almukhtar HM, Faisal IM, Merkhan MM. Effects of statins on platelet count in hyperlipidemic patients. International Journal of Pharmaceutical Research. 2020 Apr;12(2):2640-4. Go to original source...
  22. Almukhtar HM, Faisal IM, Merkhan MM. Acute effect of atorvastatin in comparison with rosuvastatin on glucose homeostasis in hypercholesteremic patients. Pharmacology. 2021;25:25-34.
  23. M Merkhan M. The effects of glibenclamide on thyroid function tests in type 2 diabetic patients. Iraqi Journal of Pharmacy. 2013 Dec 28;13(2):55-61. Doi: 10.33899/iphr.2013.86556 Go to original source...
  24. Abdulqader SW, Faisal IM, Saeed MG, et al. Fluvoxamine Provide a Gastro-Protection Against Vitiated Insult. Indian Journal of Forensic Medicine & Toxicology. 2022 Jan;16(1):1047. Go to original source...
  25. Merkhan MM, Abdullah E, Althanoon Z. Effect of Esomeprazole on serum creatinine and urea in patients with Peptic Ulcer. Age (years).;39(3.8):35-1. Go to original source...
  26. Abdullah E, Dhiaa S, Saleh K, et al. Effect of esomeprazole on lipid profile in patients with peptic ulcer. Pharmacia. 2021 Aug 17;68:613. DOI:10.3897/pharmacia.68.e70292 Go to original source...
  27. Huang D, Ou B, Prior RL. The chemistry behind antioxidant capacity assays. Journal of agricultural and food chemistry. 2005 Mar 23;53(6):1841-56. https://doi.org/10.1021/jf030723c Go to original source... Go to PubMed...
  28. Tasduq SA, Peerzada K, Koul S, et al. Biochemical manifestations of anti-tuberculosis drugs induced hepatotoxicity and the effect of silymarin. Hepatology research. 2005 Mar 1;31(3):132-5. https://doi.org/10.1016/j.hepres.2005.01.005 Go to original source... Go to PubMed...
  29. Lynch T, Neff AP. The effect of cytochrome P450 metabolism on drug response, interactions, and adverse effects. American family physician. 2007 Aug 1;76(3):391-6. Go to PubMed...
  30. Ingawale DK, Mandlik SK, Naik SR. Models of hepatotoxicity and the underlying cellular, biochemical and immunological mechanism (s): a critical discussion. Environmental toxicology and pharmacology. 2014 Jan 1;37(1):118-33. https://doi.org/10.1016/j.etap.2013.08.015 Go to original source... Go to PubMed...
  31. Schubert C, Bates WD, Moosa MR. Acute tubulointerstitial nephritis related to antituberculous drug therapy. Clinical nephrology. 2010 Jun 1;73(6):413-9. DOI: 10.5414/cnp73413 Go to original source... Go to PubMed...
  32. Graham GG, Scott KF, Day RO. Alcohol and paracetamol. https://doi.org/10.18773/austprescr.2004.009 Go to original source...
  33. Muriel P. Role of free radicals in liver diseases. Hepatology international. 2009 Dec;3(4):526-36. https://doi.org/10.1007/s12072-009-9158-6 Go to original source... Go to PubMed...
  34. Seronello S, Sheikh MY, Choi J. Redox regulation of hepatitis C in nonalcoholic and alcoholic liver. Free Radical Biology and Medicine. 2007 Sep 15;43(6):869-82. https://doi.org/10.1016/j.freeradbiomed.2007.05.036 Go to original source... Go to PubMed...
  35. Banu Rekha VV, Santha T, Jawahar MS. Rifampicin-induced renal toxicity during retreatment of patients with pulmonary tuberculosis. Journal of the Associations of Physicians of India. 2005;53(Sep):811-3.
  36. Muthukumar T, Jayakumar M, Fernando EM, et al. Acute renal failure due to rifampicin: a study of 25 patients. American Journal of Kidney Diseases. 2002 Oct 1;40(4):690-6. https://doi.org/10.1053/ajkd.2002.35675 Go to original source... Go to PubMed...
  37. Hodgkins KS, Schnaper HW. Tubulointerstitial injury and the progression of chronic kidney disease. Pediatric nephrology. 2012 Jun;27(6):901-9. https://doi.org/10.1007/s00467-011-1992-9 Go to original source... Go to PubMed...
  38. De Vriese AS, Robbrecht DL, Vanholder RC, et al. Rifampicin-associated acute renal failure: pathophysiologic, immunologic, and clinical features. American journal of kidney diseases. 1998 Jan 1;31(1):108-15. https://doi.org/10.1053/ajkd.1998.v31.pm9428460 Go to original source... Go to PubMed...
  39. González E, Gutiérrez E, Galeano C, et al. Early steroid treatment improves the recovery of renal function in patients with drug-induced acute interstitial nephritis. Kidney international. 2008 Apr 2;73(8):940-6. https://doi.org/10.1038/sj.ki.5002776 Go to original source... Go to PubMed...
  40. Wali AF, Mushtaq A, Rehman MU, et al. Amelioration of Rifampicin and Isoniazid Induced Liver Oxidative Damage and Inflammation Response by Propolis Extracts in Rodent Model. Journal of Biologically Active Products from Nature. 2019 Jan 2;9(1):57-66. https://doi.org/10.1080/22311866.2019.1570338 Go to original source...
  41. Pahlavani N, Sedaghat A, Moghaddam AB, et al. Effects of propolis and melatonin on oxidative stress, inflammation, and clinical status in patients with primary sepsis: Study protocol and review on previous studies. Clinical nutrition ESPEN. 2019 Oct 1;33:125-31. https://doi.org/10.1016/j.clnesp.2019.06.007 Go to original source... Go to PubMed...