MMSL 2023, 92(1):14-21 | DOI: 10.31482/mmsl.2022.015

VITAMIN E VERSUS PROPOLIS AS AN ADD-ON THERAPY TO SITAGLIPTIN/METFORMIN ON OXIDANT/ANTIOXIDANT STATUS AND LIPID PROFILE IN TYPE 2 DIABETIC PATIENTSOriginal article

Sarraa Dhiaa ORCID...1*, Imad A. Thanoon ORCID...2, Nabeel N. Fadhil ORCID...3
1 College of Pharmacy, Alhadbaa Street, 41002, University of Mosul, Mosul, Ninevah Province, Iraq
2 College of Medicine, Alhadbaa Street, 41002, University of Mosul, Mosul, Ninevah Province, Iraq
3 College of Medicine, Alhadbaa Street, 41002, Ninevah University, Mosul, Ninevah Province, Iraq

The main health care challenges associated with diabetic patients are glycemic control. Insulin defection has been regarded as the mainstay which needs to be tackled to avoid glucose over presence in the circulatory system. These challenges have always been conjoined with the patient’s redox status, hence, oxidants/antioxidants determine the fate of pancreatic tissue status and they are reciprocally interrelated.  Various remedies have been utilized by patients themselves and healthcare workers to control hyperglycemia if any. Herbal and pharmacological therapy were always being used hand in hand. Herein, we are demonstrating the antioxidant effect of propolis and its role in modulation of lipid profile in type 2 diabetic patients using vitamin E for comparison in sequential mode i.e. vitamin E used for 8 weeks followed one-week washout period and then propolis therapy started in the same group of patients (n = 45). Thereby a sample of serum has been collected in the first visit (baseline and vitamin E started, followed by collecting serum after 8 weeks (second visit); followed by commencing of propolis after a washout week from the second visit, at the third visit another serum sample collected from all patients. Serum was analyzed for oxidant/antioxidant status represented by malondialdehyde (MDA) and total antioxidant status (TAS). Additionally, lipid profile has been measured from the same samples. The results indicate that both propolis and vitamin E positively modulated the measured parameters with superiority of propolis over vitamin E in improving these measured biomolecules. To conclude, propolis is an overall safe natural product and is inducing such positive effects in the diabetic patient, we do advise these patients to start propolis therapy as an adjuvant medication to control these deleterious biomolecules.

Keywords: Vitamin E; Propolis; Sitagliptin; Lipid; TAS; MDA; Diabetes

Received: January 28, 2022; Revised: February 7, 2022; Accepted: March 28, 2022; Prepublished online: April 4, 2022; Published: March 3, 2023  Show citation

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Dhiaa, S., Thanoon, I.A., & Fadhil, N.N. (2023). VITAMIN E VERSUS PROPOLIS AS AN ADD-ON THERAPY TO SITAGLIPTIN/METFORMIN ON OXIDANT/ANTIOXIDANT STATUS AND LIPID PROFILE IN TYPE 2 DIABETIC PATIENTS. MMSL, 92(1), 14-21. doi: 10.31482/mmsl.2022.015
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