MMSL 2023, 92(1):22-28 | DOI: 10.31482/mmsl.2022.016

DRUG-INDUCED ACUTE PANCREATITIS – LITERATURE OVERVIEW AND OUR EXPERIENCEReview article

Ján Csomor ORCID...1,2*, Petr Hříbek ORCID...1,2, Petr Urbánek ORCID...1
1 ÚVN, Interní klinika 1. LF UK a ÚVN, Praha, Česká Republika
2 Fakulta vojenského zdravotnictví, Univerzita Obrany, Hradec Králové, Česká Republika

Polékové akutní pankreatitidy patří celosvětově mezi nejvzácnější akutní pankreatitidy. V mezinárodní literatuře i statistických souborech je jejich výskyt udáván mezi 0,1 % až 2 % všech případů akutní pankreatitidy. K dnešnímu dni je definováno více než 200 potenciálně nebezpečných léků, které mohou indukovat akutní pankreatitidu. Exaktní mechanismus této polékové reakce je nejasný a diagnóza se opírá většinou o vyloučení jiných, mnohem častějších příčin pankreatitidy (hlavně biliární a alkoholové) a časovou souvislost s podáním nové, potenciálně rizikové medikace.

Keywords: poléková reakce; akutní pankreatitida

Drug induced acute pancreatitis is worldwide a very rare cause of acute pancreatitis at all. In the literature and in the statistics it comprises only 0.1-2 % of all cases of acute pancreatitis. Nowadays, more than 200 potential dangerous drugs are specified, that they can cause acute pancreatitis. The exact mechanism of this adverse drug reaction is still unclear and to establish the diagnosis one has to exclude more common form of acute pancreatitis (caused especially by gallstones and alcohol) and find the time connection with recieving a new, risky medication.

Keywords: adverse drug reaction; acute pancreatitis

Received: February 3, 2022; Revised: March 16, 2022; Accepted: March 28, 2022; Prepublished online: April 6, 2022; Published: March 3, 2023  Show citation

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Csomor, J., Hříbek, P., & Urbánek, P. (2023). DRUG-INDUCED ACUTE PANCREATITIS – LITERATURE OVERVIEW AND OUR EXPERIENCE. MMSL, 92(1), 22-28. doi: 10.31482/mmsl.2022.016
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