MMSL 2024, 93(3):297-311 | DOI: 10.31482/mmsl.2023.033
THE BOON AND BANE OF PARTHENIUM HYSTEROPHORUS FOR HUMAN HEALTHReview article
- 1 Department of Pharmacy, Quantum School of Health Sciences, Quantum University, Roorkee, Uttarakhand, 247662, India
- 2 School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, 302017, India
The annual or ephemeral plant Parthenium hysterophorus L. is an upright and heavily branched member of the Asteraceae family. The herb is used to treat heart issues, fever, anemia, wounds, and ulcerated sores. It is applied topically to treat skin issues, while the plant’s decoction is frequently taken orally to address a wide range of ailments. Psoriasis, rheumatoid arthritis, diarrhea, urinary tract infections, dysentery, malaria, psoriasis, allergies, asthma, tinnitus, nausea, vomiting, and neuralgia are just a few of the health benefits that P. hysterophorus L. can provide. Asthma, bronchitis, dermatitis, and hay fever are some of the major problems caused by this weed, which is harmful to all living things because it also depletes nutrient levels and competes with the cultivation of major crops and vegetation. This review discusses the potential health benefits as well as the origin, distribution, morphology, and harmful effects of the plant on human health.
Keywords: Pharmacological activities; Health benefits; Harmful effects; Weed; Asteraceae
Received: April 1, 2023; Revised: July 16, 2023; Accepted: July 31, 2023; Prepublished online: August 8, 2023; Published: September 2, 2024 Show citation
References
- Lalita, Kumar A. Review on a weed Parthenium hysterophorus (L.). Int J Curr Res Rev. 2018;10(17):23-32.
Go to original source...
- Shenefelt PD. Herbal Treatment for Dermatologic Disorders. Herbal Medicine: Biomolecular and Clinical Aspects: Second Edition [Internet]. 2011;383-403. Available from: https://www.ncbi.nlm.nih.gov/books/NBK92761/
Go to original source...
- Choudhary S, Noor MU, Hussain MS, et al. Allium sativum L.: Therapeutic uses and pharmacological properties. Biogenesis: Jurnal Ilmiah Biologi [Internet]. 2022;10(2). Available from: https://journal.uin-alauddin.ac.id/index.php/biogenesis/article/view/33672
- Tessema T, Hoppe B, Janke J, et al. Parthenium weed (Parthenium hysterophorus L.) research in Ethiopia: Investigation of pathogens as biocontrol agents. Ethiopian Journal of Agricultural Sciences [Internet]. 2016;21(1-2):107-27. Available from: https://www.ajol.info/index.php/ejas/article/view/142889
- Saini A, Aggarwal NK, Sharma A, et al. Utility Potential of Parthenium hysterophorus for Its Strategic Management. Advances in Agriculture. 2014.
Go to original source...
- Abdeta ABC. A Review on the Distribution, Biology and Management Practices of Parthenium Weed, (Parthenium hysterophorus L.) in Ethiopia. J Biol Agric Healthc [Internet]. 2016;6(5):136-145. Available from: https://www.iiste.org/Journals/index.php/JBAH/article/view/29494
- Belgeri A, Bajwa AA, Shabbir A, et al. Managing an Invasive Weed Species, Parthenium hysterophorus, with Suppressive Plant Species in Australian Grasslands. Plants. 2020;9(11):1587. Available from: https://www.mdpi.com/2223-7747/9/11/1587/htm
Go to original source...
Go to PubMed...
- Rai A. Antimicrobial, Antioxidant and Cytotoxic Activity of Green Synthesized Copper Nanoparticle of Parthenium Hysterophorus L. INTERNATIONAL JOURNAL OF MULTIDISCIPLINARY RESEARCH AND ANALYSIS. 2021 Feb 4;04(02).
Go to original source...
- Adkins S, Shabbir A. Biology, ecology and management of the invasive parthenium weed (Parthenium hysterophorus L.). Pest Manag Sci [Internet]. 2014;70(7):1023-1029. Available from: https://pubmed.ncbi.nlm.nih.gov/24430973/
Go to original source...
Go to PubMed...
- Satao NT, Shinde N. Extraction of Parthenin from Parthenium Hysterophorus. 2014;
- Marwat SK, Fazal-ur-Rehman, Khan IU. Ethnobotanical Importance and Phytochemical constituents of Parthenium weed (Parthenium hysterophorus L.) - A Review. Plant Science Today [Internet]. 2015;2(2):77-81. Available from: https://horizonepublishing.com/journals/index.php/PST/article/view/113
Go to original source...
- Kaur L, Malhi DS, Cooper R, et al. Comprehensive review on ethnobotanical uses, phytochemistry, biological potential and toxicology of Parthenium hysterophorus L.: A journey from noxious weed to a therapeutic medicinal plant. J Ethnopharmacol [Internet]. 2021;281. Available from: https://pubmed.ncbi.nlm.nih.gov/34411657/
Go to original source...
Go to PubMed...
- Mcconnachie AJ, Strathie LW, Mersie W, et al. Current and potential geographical distribution of the invasive plant Parthenium hysterophorus (Asteraceae) in eastern and southern Africa. Weed Res. 2011;51(1):71-84.
Go to original source...
- Nimal Chandrasena NC, Rao AN. Parthenium weed: uses and abuses. Parthenium weed: biology, ecology and management. 2018 Nov 30;190-211.
Go to original source...
- Bezuneh TT. Phytochemistry and Antimicrobial Activity of Parthenium hysterophorus L.: A Review. http://www.sciencepublishinggroup.com [Internet]. 2015;3(3):30. Available from: http://www.sciencepublishinggroup.com/j/sjac
Go to original source...
- Birhanu A, Khan PR. The distribution, status and mitigation methods of Parthenium hysterophorus L. in Ethiopia: A review. ~ 5 ~ Journal of Medicinal Plants Studies. 2018;6(4):5-10.
- Dey S, Sinha B, Kalita J. Effect of Eupatorium adenophorum Spreng leaf extracts on the mustard aphid, Lipaphis erysimi Kalt: A scanning electron microscope study. Microsc Res Tech. 2005;66(1):31-36.
Go to original source...
Go to PubMed...
- Jaiswal J, Singh N, Gupta VK, et al. Pharmacological Chemistry and Biomedical Implications of Chemical Ingredients from Parthenium hysterophorus. Curr Top Med Chem [Internet]. 2022;22(23):1950-1965. Available from: https://pubmed.ncbi.nlm.nih.gov/35255797/
Go to original source...
Go to PubMed...
- Weyl P. Parthenium hysterophorus (parthenium weed). CABI Compendium. 2022 Jan 7;CABI Compendium.
Go to original source...
- Kaur M, Aggarwal NK, Kumar V, Dhiman R. Effects and Management of Parthenium hysterophorus : A Weed of Global Significance . Int Sch Res Notices. 2014;2014:1-12.
Go to original source...
Go to PubMed...
- Javaid A, Adrees H. Parthenium management by cultural filtrates of phytopathogenic fungi. http://dx.doi.org/101080/14786410902726167 [Internet]. 2009;23(16):1541-1551. Available from: https://www.tandfonline.com/doi/abs/10.1080/14786410902726167
Go to original source...
- Allan S, Shi BoYang SB, Adkins SW. Impact of parthenium weed on human and animal health. Parthenium weed: biology, ecology and management. 2018;105-130.
Go to original source...
- Ratnaparkhe S, Ratnaparkhe MB. Parthenium hysterophorus: Weed to Value. Bioremediation using weeds [Internet]. 2021;79-96. Available from: https://www.academia.edu/65813553/Parthenium_hysterophorus_Weed_to_Value
Go to original source...
- Mao R, Shabbir A, Adkins S. Parthenium hysterophorus: A tale of global invasion over two centuries, spread and prevention measures. J Environ Manage [Internet]. 2021;279. Available from: https://pubmed.ncbi.nlm.nih.gov/33310235/
Go to original source...
Go to PubMed...
- Kaur A, Kaur S, Jandrotia R, et al. Parthenin-A Sesquiterpene Lactone with Multifaceted Biological Activities: Insights and Prospects. Molecules [Internet]. 2021;26(17). Available from: /pmc/articles/PMC8434391/
Go to original source...
Go to PubMed...
- Rice C, Wolf J, Fleisher DH, et al. Recent CO2 levels promote increased production of the toxin parthenin in an invasive Parthenium hysterophorus biotype. Nat Plants [Internet]. 2021 Jun 1 [cited 2023 Feb 12];7(6):725-729. Available from: https://pubmed.ncbi.nlm.nih.gov/34099902/
Go to original source...
Go to PubMed...
- Balaich JN, Mathias DK, Torto B, et al. The Nonartemisinin Sesquiterpene Lactones Parthenin and Parthenolide Block Plasmodium falciparum Sexual Stage Transmission. Antimicrob Agents Chemother [Internet]. 2016 Apr 1 [cited 2023 Feb 12];60(4):2108. Available from: /pmc/articles/PMC4808191/
Go to original source...
Go to PubMed...
- Singh P, Kushwaha PP, Kumar S. Parthenin and Its Similar Structure as Potential Lead Inhibitors of Plasmodium vivax and Plasmodium falciparum Lactate Dehydrogenase. Phytochemistry: An in-silico and in-vitro Update. 2019;565-77.
Go to original source...
- Smolinski AT, Pestka JJ. Comparative effects of the herbal constituent Parthenolide (Feverfew) on lipopolysaccharide-induced inflammatory gene expression in murine spleen and liver. J Inflamm (Lond) [Internet]. 2005;2:6. Available from: /pmc/articles/PMC1185559/
Go to original source...
Go to PubMed...
- Baud V, Karin M. Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls. Nat Rev Drug Discov [Internet]. 2009;8(1):33-40. Available from: https://pubmed.ncbi.nlm.nih.gov/19116625/
Go to original source...
Go to PubMed...
- Mathema VB, Koh YS, Thakuri BC, et al. Parthenolide, a sesquiterpene lactone, expresses multiple anticancer and anti-inflammatory activities. Inflammation [Internet]. 2012;35(2):560-565. Available from: https://pubmed.ncbi.nlm.nih.gov/21603970/
Go to original source...
Go to PubMed...
- Ali F, Rahul, Naz F, et al. Health functionality of apigenin: A review. http://dx.doi.org/101080/1094291220161207188 [Internet]. 2016;20(6):1197-1238. Available from: https://www.tandfonline.com/doi/abs/10.1080/10942912.2016.1207188
Go to original source...
- Salehi B, Venditti A, Sharifi-Rad M, et al. The Therapeutic Potential of Apigenin. Int J Mol Sci [Internet]. 2019;20(6). Available from: /pmc/articles/PMC6472148/
Go to original source...
Go to PubMed...
- Jaiswal J, Singh N, Gupta VK, et al. Pharmacological Chemistry and Biomedical Implications of Chemical Ingredients from Parthenium hysterophorus. Curr Top Med Chem [Internet]. 2022;22(23):1950-1965. Available from: https://pubmed.ncbi.nlm.nih.gov/35255797/
Go to original source...
Go to PubMed...
- Bezerra GSN, Pereira MAV, Ostrosky EA, et al. Compatibility study between ferulic acid and excipients used in cosmetic formulations by TG/DTG, DSC and FTIR. J Therm Anal Calorim. 2017;127(2):1683-1691.
Go to original source...
- Aguilar-Hernández I, Afseth NK, López-Luke T, et al. Surface enhanced Raman spectroscopy of phenolic antioxidants: A systematic evaluation of ferulic acid, p-coumaric acid, caffeic acid and sinapic acid. Vib Spectrosc. 2017;89:113-122.
Go to original source...
- Zduńska K, Dana A, Kolodziejczak A, et al. Antioxidant Properties of Ferulic Acid and Its Possible Application. Skin Pharmacol Physiol [Internet]. 2018;31(6):332-336. Available from: https://pubmed.ncbi.nlm.nih.gov/30235459/
Go to original source...
Go to PubMed...
- Alam MA. Antihypertensive Effect of Cereal Antioxidant Ferulic Acid and Its Mechanism of Action. Front Nutr [Internet]. 2019;6:121. Available from: /pmc/articles/PMC6692439/
Go to original source...
Go to PubMed...
- Khan F, Bamunuarachchi NI, Tabassum N, et al. Caffeic Acid and Its Derivatives: Antimicrobial Drugs toward Microbial Pathogens. J Agric Food Chem [Internet]. 2021;69(10):2979-3004. Available from: https://pubmed.ncbi.nlm.nih.gov/33656341/
Go to original source...
Go to PubMed...
- Fazal H, Ahmad N, Ullah I, et al. Antibacterial potential in Parthenium hysterophorus, Stevia rebaudiana and Ginkgo biloba. Pak J Bot. 2011;43(2):1307-1313.
- Sharma DS. ANTIMICROBIAL POTENTIAL OF A WEED PLANT PARTHENIUM HYSTEROPHORUS : AN INVITRO STUDY. 2012;
- Jain NK, Kulkarni SK. Antinociceptive and anti-inflammatory effects of Tanacetum parthenium L. extract in mice and rats. J Ethnopharmacol [Internet]. 1999;68(1-3):251-259. Available from: https://pubmed.ncbi.nlm.nih.gov/10624885/
Go to original source...
Go to PubMed...
- Yamamoto T, Nozaki-Taguchi N, Chiba T. Analgesic effect of intrathecally administered orexin-A in the rat formalin test and in the rat hot plate test. Br J Pharmacol [Internet]. 2002;137(2):170. Available from: /pmc/articles/PMC1573477/
Go to original source...
Go to PubMed...
- Williams CA, Harborne JB, Geiger H, et al. The flavonoids of Tanacetum parthenium and T. vulgate and their anti- inflammatory properties. Phytochemistry [Internet]. 199951(3):417-423. Available from: https://pubmed.ncbi.nlm.nih.gov/10382317/
Go to original source...
- Patel S. Harmful and beneficial aspects of Parthenium hysterophorus: an update. 3 Biotech [Internet]. 2011;1(1):1. Available from: /pmc/articles/PMC3339593/
Go to original source...
Go to PubMed...
- Valdés AFC, Martínez JM, Lizama RS, et al. In vitro antimalarial activity and cytotoxicity of some selected cuban medicinal plants. Rev Inst Med Trop Sao Paulo [Internet]. 2010;52(4):197-201. Available from: https://pubmed.ncbi.nlm.nih.gov/21748227/
Go to original source...
Go to PubMed...
- Talakal TS, Dwivedi SK, Sharma SR. In vitro and in vivo antitrypanosomal activity of Xanthium strumarium leaves. J Ethnopharmacol. 1995;49(3):141-145.
Go to original source...
Go to PubMed...
- Zaheer Z, Shafique S, Shafique S, et al. Antifungal potential of Parthenium hysterophorus L. plant extracts against Fusarium solani. Scientific Research and Essays [Internet]. 2012;7(22):2049-2054. Available from: http://www.academicjournals.org/SRE
Go to original source...
- Bashar HMK, Juraimi AS, Ahmad-Hamdani MS, et al. A Mystic Weed, Parthenium hysterophorus: Threats, Potentials and Management. Agronomy 2021, Vol 11, Page 1514 [Internet]. 2021;11(8):1514. Available from: https://www.mdpi.com/2073-4395/11/8/1514/htm
Go to original source...
- Talakal TS, Dwivedi SK, Sharma SR. In vitro and in vivo antitrypanosomal activity of Xanthium strumarium leaves. J Ethnopharmacol. 1995;49(3):141-145.
Go to original source...
Go to PubMed...
- Meena RK, Dutt B, Kumar R, et al. Phyto-Chemistry of Congress grass (Parthenium hysterophorus L.) and Harmful and Beneficial effect on Human and Animals: A review. Int J Chem Stud [Internet]. 2017;5(4):643-647. Available from: https://www.chemijournal.com/archives/?year=2017&vol=5&issue=4&ArticleId=718&si=false
- Kumar S, Pandey S, Pandey AK. In Vitro Antibacterial, Antioxidant, and Cytotoxic Activities of Parthenium hysterophorus and Characterization of Extracts by LC-MS Analysis. Biomed Res Int [Internet]. 2014;2014. Available from: /pmc/articles/PMC4033558/
Go to original source...
Go to PubMed...
- Sahrawat A, Sharma J, Nandan Rahul S, et al. Parthenium hysterophorus Current Status and Its Possible Effects on Mammalians-A Review. IntJCurrMicrobiolAppSci [Internet]. 2018;7(11):3548-3557. Available from: https://doi.org/10.20546/ijcmas.2018.711.407
Go to original source...
- Kumar S, Chashoo G, Saxena AK, et al. Parthenium hysterophorus: a probable source of anticancer, antioxidant and anti-HIV agents. Biomed Res Int [Internet]. 2013;2013. Available from: https://pubmed.ncbi.nlm.nih.gov/24350290/
Go to original source...
Go to PubMed...
- Maciej Serda, Becker FG, Cleary M, et al. Synteza i aktywność biologiczna nowych analogów tiosemikarbazonowych chelatorów żelaza. G. Balint, Antala B, Carty C, Mabieme JMA, Amar IB, Kaplanova A, editors. Uniwersytet śląski [Internet]. 2013;7(1):343-354. Available from: https://desytamara.blogspot.com/2017/11/sistem-pelayanan-perpustakaan-dan-jenis.html
- Sztiller-Sikorska M, Czyz M. Parthenolide as Cooperating Agent for Anticancer Treatment of Various Malignancies. Pharmaceuticals (Basel) [Internet]. 2020;13(8):1-30. Available from: https://pubmed.ncbi.nlm.nih.gov/32823992/
Go to original source...
Go to PubMed...
- Jha U, Chhajed PJ, Oswal RJ, et al. Skeletal muscle relaxant activity of methanolic extract of Parthenium hysterophorus L. leaves in Swiss Albino mice. International Journal of Pharmacy and Life Sciences (IJPLS). 2011;2(11):1211-1213.
- Jha U, Chhajed PJ, Oswal R, et al. Skeletal muscle relaxant activity of methanolic extract of Parthenium hysterophorus L. leaves in swiss albino mice. 2011;
- Kumar S, Singh AP, Nair G, et al. Impact of Parthenium hysterophorus leaf extracts on the fecundity, fertility and behavioural response of Aedes aegypti L. Parasitol Res [Internet]. 2011;108(4):853-859. Available from: https://pubmed.ncbi.nlm.nih.gov/20978787/
Go to original source...
Go to PubMed...
- Abdelhadi AA, Elkheir YM, Hassan T, et al. NEUROMUSCULAR BLOCKING ACTIVITY OF A CRUDE AQUEOUS EXTRACT OF IPOMOEA FISTULOSA. Clin Exp Pharmacol Physiol. 1986;13(2):169-171.
Go to original source...
Go to PubMed...
- Khaket TP, Aggarwal H, Jodha D, et al. Parthenium hysterophorus in current scenario: A toxic weed with industrial, agricultural and medicinal applications. Journal of Plant Sciences. 2015;10(2):42-53.
Go to original source...
- Khan RA, Ahmed M, Khan MR, et al. Nutritional investigation and biological activities of parthenium hysterophorus. Afr J Pharm Pharmacol. 2011;5(18):2073-2078.
Go to original source...
- Natukunda MI, Natukunda K, Kyeyune G, et al. Management strategies for the noxious invasive parthenium weed (Parthenium hysterophorus L.) in Uganda. Afr J Agric Res [Internet]. 2020;15(1):1-9. Available from: https://academicjournals.org/journal/AJAR/article-abstract/6652D2F62620
Go to original source...
- Amare T. Allelopathic Effect of Aqueous Extracts of Parthenium ( Parthenium hysterophorus L.) Parts on Seed Germination and Seedling Growth of Maize ( Zea Mays L.). Journal of Agriculture and Crops [Internet]. 2018;4(12):157-163. Available from: https://ideas.repec.org/a/arp/jacarp/2018p157-163.html
- Sushilkumar. Spread, menace and management of Parthenium. Indian Journal of Weed Science. 2014;46(3):205-219.
- Thesis MS, Ayele S. THE IMPACT OF PARTHENIUM (PARTHENIUM HYSTEROPHORUS L.) ON THE RANGE ECOSYSTEM DYNAMICS OF THE JIJIGA RANGELAND, ETHIOPIA. 2007.
- Magnoli K, Carranza CS, Aluffi ME, et al. Herbicides based on 2,4-D: its behavior in agricultural environments and microbial biodegradation aspects. A review. Environmental Science and Pollution Research. 2020;27(31):38501-38512.
Go to original source...
Go to PubMed...
- Maszura CM, Karim SMR, Norhafizah MZ, et al. Distribution, Density, and Abundance of Parthenium Weed (Parthenium hysterophorus L.) at Kuala Muda, Malaysia. International Journal of Agronomy. 2018;2018.
Go to original source...
- Horo JT, Gudisa T, Worku E, et al. Distribution and Abundance of Parthenium hysterophorus L. in Metekel Zone, Northwest Ethiopia. American Journal of Plant Sciences. 2020 Jul 7;11(7):1101-1110.
Go to original source...
- Ojija F, Arnold SE, Treydte AC. Plant competition as an ecosystem-based management tool for suppressing Parthenium hysterophorus in rangelands. Rangelands. 2021 Apr 1;43(2):57-64.
Go to original source...
- Masum SM, Hasanuzzaman M, Ali MH. Threats of Parthenium hysterophorus on agroecosystems and its management: a review. International Journal of Agriculture and Crop Sciences. 2013;6(11):684.
- Ravindra K, Goyal A, Kumar S, et al. Pollen Calendar to depict seasonal periodicities of airborne pollen species in a city situated in Indo-Gangetic plain, India. Atmospheric Environment. 2021;262:118649.
Go to original source...
- Lakshmi C, Srinivas CR. Parthenium: A wide angle view. Indian Journal of Dermatology, Venereology and Leprology. 2007;73:296.
Go to original source...
Go to PubMed...
- Lazzaro L, Essl F, Lugliè A, et al. Invasive alien plant impacts on human health and well-being. Invasive species and human health. Eds. Mazza G, Tricario E. Wallingford: CAB International. 2018:16-33.
Go to original source...
- Nguyen T, Bajwa AA, Belgeri A, et al. Impact of an invasive weed, Parthenium hysterophorus, on a pasture community in south east Queensland, Australia. Environmental Science and Pollution Research. 2017;24:27188-27200.
Go to original source...
Go to PubMed...
- Tiruneh S, Tegene F. Impacts of climate change on Livestock production and productivity and different adaptation strategies in Ethiopia. Journal of Applied and Advanced Research. 2018;3(3):52-58.
Go to original source...
- Tamado T, Ohlander L, Milberg P. Interference by the weed Parthenium hysterophorus L. with grain sorghum: influence of weed density and duration of competition. International Journal of Pest Management. 2002;48(3):183-188.
Go to original source...
- Rana RS, Dhillon BS, Khetarpal RK. Invasive alien species: the Indian scene. Indian Journal of Plant Genetic Resources. 2003;16(3):190-213.
- Byrne MJ, du Plessis D, Ivey PJ, et al. Education, training and capacity-building in the field of biological invasions in South Africa. Biological Invasions in South Africa. 2020;731.
Go to original source...