MMSL 2024, 93(3):274-287 | DOI: 10.31482/mmsl.2023.034

THE ROLE OF SERUM MIDKINE IN THE DIAGNOSIS AND PROGNOSIS OF THE COLORECTAL CARCINOMAOriginal article

Ali H. Abd-Allah ORCID...1,*, Haider A. Jabbar1,2, Mazen J. Ibrahim2
1 Department of Clinical Biochemistry, College of Medicine, University; of Al- Qadisiyah, Iraq
2 Department of Oncology, College of Medicine, University of Baghdad, Iraq

Background: The second-leading source of neoplasm-related death and a primary factor in gastrointestinal cancer, colorectal cancer (CCR) affects both genders globally. Poor eating behaviours, tobacco, an intestinal inflammatory disorder, swellings, inherited characteristics, and the elderly all increase the threat of acquiring this malignancy. The illness is more hostile in patients detected at earlier ages, although 90% of patients with colorectal tumours are older than 50, with a median oldness of 64 years. American Cancer Association estimates that it caused more than 49,700 fatalities in 2015.

Objectives: Study the correlation of midkine with carcinoembryonic antigen (CEA), liver function tests, and white blood cell count in patients with colorectal carcinoma.

Methods: The serum midkine and CEA of all subjects were measured by the ELISA technique, Liver enzymes were measured by colourimetric methods and neutrophils, and lymphocytes were measured by an Electrical Impedance Cell Counting method (automated machine).

Conclusion: The study results of the correlation between serum midkine and other parameters in colorectal carcinoma patients show a significant positive correlation of midkine with CEA, liver enzyme, neutrophils, and lymphocytes.

Keywords: Colorectal carcinoma; Liver enzymes; Lymphocytes; Neutrophils; Midkine

Received: May 31, 2023; Revised: May 31, 2023; Accepted: July 31, 2023; Prepublished online: August 14, 2023; Published: September 2, 2024  Show citation

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Abd-Allah, A.H., Jabbar, H.A., & Ibrahim, M.J. (2024). THE ROLE OF SERUM MIDKINE IN THE DIAGNOSIS AND PROGNOSIS OF THE COLORECTAL CARCINOMA. MMSL, 93(3), 274-287. doi: 10.31482/mmsl.2023.034
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