MMSL, 2016 (vol. 85), issue 2
IRRITANT COMPOUNDS: MILITARY RESPIRATORY IRRITANTS. PART II. STERNUTATORSReview article
Jiří Patočka, Kamil Kuča
MMSL 2016, 85(2):50-55 | DOI: 10.31482/mmsl.2016.010 
Sternutators are substances that irritate the nasal and respiratory passages and cause coughing, sneezing, lacrimation, and sometimes vomiting. They are organoarsenic compounds and some of them were used as warfare toxic gases in World War I, namely diphenylaminochloroarsine, diphenylchloroarsine, diphenylcyanarsine, and phenyldichloroarsine. The effect of these irritants is in principle non-lethal.
CURRENT ADJUSTMENTS IN TEACHING AND TRAINING STUDENTS AT THE FACULTY OF MILITARY HEALTH SCIENCES, UNIVERSITY OF DEFENCEOriginal article
Milan Růžička, Vojtěch Humlíček, Michal Potáč, Jaroslav Žďára, Petra Vrtíšková
MMSL 2016, 85(2):56-62 | DOI: 10.31482/mmsl.2016.011
The University of Defence (UD) provides comprehensive education and training of students to get knowledge and skills which enable graduates to manage activities in the area of management and leadership. Formerly, the UD students received military and leadership skills especially within the military training outside the UD in basic training, in the Career course or the Specialized officer course at the Training Command - Military Academy (TC-MA) in Vyškov. Currently, the UD has included the Officer course into its own teaching curriculum, and thus bears a full responsibility for comprehensive preparedness of the UD graduates for their assignment to...
BLOOD-FETUS PENETRATION OF PRALIDOXIMEOriginal article
Shreesh Ojha, Syed M. Nurulain, S. Dhanasekaran, Mohammad Shafiullah, Abdu Adem, Charu Sharma, Kamil Kuča, Huba Kalasz
MMSL 2016, 85(2):63-68 | DOI: 10.31482/mmsl.2016.012
Pralidoxime (2-PAM) is a monopyridinium aldoxime-type compound of acetylcholinesterase reactivators. 2-PAM was introduced about five decades ago for the treatment of organophosphorus poisoning in order to reactivate inhibited acetylcholinesterase. The application of organophosphorus compounds is varied, including warfare agents, insecticides and pesticides in agriculture, the chemical industry, etc. The exposure is not limited to certain groups of humans: rather everyone can be affected, including pregnant women, and consequently fetuses as well.The present study was aimed to determine the 2-PAM concentration in the plasma of pregnant mice, assuming...
RENAL CELL LINES FOR STUDY OF NEPHROTOXICITY IN VITROReview article
Martina Vrbová, Eva Dastychová, Tomáš Roušar
MMSL 2016, 85(2):69-74 | DOI: 10.31482/mmsl.2016.013
The kidneys are one of the organ that can be commonly damaged by a number of toxic compounds (heavy metals, xenobiotics, drugs, etc.). To characterize the mechanism of toxicity, a variety of methods have been developed. The in vitro methods belong among the mostly used. Especially, the use of cell lines seems to be the leading approach to test and to characterize the toxicity mechanisms. At present, several cell lines of animal (from rat, dog, pig) or human origin are available. A detailed evaluation must go before any selection of a suitable cell line for experiments. Therefore, the aim of this review was to describe and to evaluate the mostly...
VIRTUAL SCREENING IN DRUG DESIGN - OVERVIEW OF MOST FREQUENT TECHNIQUESReview article
Tomáš Kučera
MMSL 2016, 85(2):75-79 | DOI: 10.31482/mmsl.2016.014
New and modern techniques of drug design are extensively used in parallel or instead of the classic ones. Applicability of virtual screening (VS) is growing with the computational performance. This article includes list and short description of most frequent used methods in VS. These methods are divided into two groups - ligand-based VS and structure-based VS. Ligand based methods include chemical similarity, pharmacophore and quantitative structure-activity relationship. Molecular docking and scoring are methods of the structure-based VS.
BIOACTIVE METABOLITES OF ENTOMOPATHOGENIC FUNGI Beauveria bassianaReview article
Jiří Patočka
MMSL 2016, 85(2):80-88 | DOI: 10.31482/mmsl.2016.015
Beauveria bassiana is a fungus which causes disease in insects. Currently it is used as an insecticide to control pest populations. Fungi are known to produce a vast array of secondary metabolites that are important for biotechnological applications. Furthemore, B. bassiana is an interesting source of biologically active molecules. There are alkaloids with the structure of 2-pyridone, dibenzoquinone pigments and different cyclodepsipeptides. Cyclodepsipeptides from B. bassiana are interesting for their neuroprotective properties. Interest of psychopharmacology is focused on the group of beauveriolides. Plant B. bassiana...
REPORT FROM 16th MILITARY MEDICAL SERVICES CONFERENCELetter to the editor
Jaroslav Žďára, Petr Král, Božena Vašínová, Lada Kovářová
MMSL 2016, 85(2):89-91
Military Training Area Libava was the venue for the 16th Military Medical Services Conference. This event has a long tradition and it became an integral part of military education actions. We can say, that the level of the conference is gradually improving year by year...
DISCUSSION FORUM 2016 - HOST PATHOGEN INTERACTIONAnnouncement
Klára Kubelková
MMSL 2016, 85(2):92
Conference with international participation. The interaction between host and pathogen with enlargement to other aspects of the analysis of biological material.