MMSL 2024, 93(3):247-254 | DOI: 10.31482/mmsl.2023.029

OXIDATIVE STRESS ALTERS THE THERAPEUTIC EFFECTS OF KETOROLAC IN THE CHICKS MODELOriginal article

Rafal L. Abdulah ORCID..., Yaareb J. Mousa ORCID...*
Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Mosul, Almajmoaa Street, 41002, Mosul, Nineveh Province, Iraq

The purpose of the research consisted of assessing the modification produced by hydrogen peroxide (H2O2)-induced oxidative stress (OS) on the ketorolac therapeutic effects in the chickens which are the analgesic, antipyretic, and anti-inflammatory. A significant decrease in the total antioxidant capacity (T-AOC) and subsequent occurrence of OS was observed in the stressed (H2O2) group on days 7th, 10th, and 14th by 39, 29, and 41%, respectively in comparison to the control (non-stressed) group. The analgesic effect of ketorolac in the stressed group had more intense in comparison to the non-stressed group, the analgesic effectiveness of ketorolac raised by 16% in that group. In the non-stressed and stressed groups, ketorolac produces its antipyretic effect at 3 and 4 hours after fever induction by baker’s yeast while it shows the effect significantly at 1, 2, and 4 hours. Furthermore, ketorolac has the superiority of antipyretic action in stressed group over the non-stressed group. Ketorolac carries out anti-inflammatory activity in the stressed and non-stressed groups by 61 and 75%, respectively. Ketorolac has a significant anti-inflammatory property in the stressed group through a significant decrease in the delta thickness compared to the non-stressed group. The stressed group was treated with ketorolac for five consecutive days signifi-cantly affect the kidney and liver function concerning the non-stressed group. The net findings proposed the ability of H2O2-induced OS to alter ketorolac’s analgesic, antipyretic, and anti-inflammatory properties in the chickens thus, it is recommended to reduce the dose of ketorolac intended to be given to stressed animals involved.

Keywords: Analgesic; Antipyretic; Antiinflammatory; Oxidative stress; Ketorolac

Received: April 4, 2023; Revised: May 15, 2023; Accepted: May 26, 2023; Prepublished online: June 7, 2023; Published: September 2, 2024  Show citation

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Abdulah, R.L., & Mousa, Y.J. (2024). OXIDATIVE STRESS ALTERS THE THERAPEUTIC EFFECTS OF KETOROLAC IN THE CHICKS MODEL. MMSL, 93(3), 247-254. doi: 10.31482/mmsl.2023.029
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