The aim of the study was to evaluate models for studying possible preventive effects of selective antioxidants on biochemical changes induced by chronic intrauterine hypoxia and neonatal anoxia in Wistar//DV rats. Anoxia of newborn rats and chronic intrauterine hypoxia induced by phenytoin caused oxidative stress followed by organ ischaemia/reperfusion and reactive oxygen species generation. In biochemical quantification of oxidative stress we used the activity of the lysosomal enzyme N-acetyl-B-D-glucosaminidase (NAGA) and the level of glutathione (GSH) in foetal liver and brain, and in the placenta and brain, lungs and liver of newborn rats as markers of tissue damage. Neonatal anoxia (25 min) in 2-day-old pups induced significant increase in NAGA activity in lungs and liver and GSH increase in brain and liver. The activity of NAGA in brain....

Keywords: Toxicology; oxidative stress