MMSL 2001, 70(S2):79-82
STRUCTURAL AND FUNCTIONAL CHANGES IN RAT OFFSPRING INDUCED BY PRENATAL PHENYTOIN ADMINISTRATION
- 1 Institute Of Experimental Pharmacology, SASc, Bratislava, Slovak Republic
- 2 Hospital of Ministry of Defence, Bratislava, Slovak Republic
Phenytoin (sodium salt), a developmental neurotoxicant, was administered orally by gavage (150 mg/kg) to pregnant rats on days 7—18 of gestation. Various developmental and behavioural indices were evaluated. This study suggest that prenatal phenytoin exposure may result in developmental, behavioural deficits and neurochemical changes.
Keywords: Toxicology; phenytoin
Published: December 2, 2001 Show citation
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Mach, M., Ujházy, E., Dubovický, M., Navarová, J., Blažíček, P., & Šoltés, L. (2001). STRUCTURAL AND FUNCTIONAL CHANGES IN RAT OFFSPRING INDUCED BY PRENATAL PHENYTOIN ADMINISTRATION. Vojenské Zdravotnické Listy, 70(Suppl.2), 79-82
