The aim of the work was the comparison of effects of bile acids, mostly used in the therapy, on some parameters of heart activity after their chronical administration. Their possible effects on cardiovascular system are partially known from literature (1,2). Chenodeoxycholic acid (CDCA), ursodeoxycholic acid (UDCA) and deoxycholic acid (DCA) were administered orally once a day in doses 1 g/kg and 0.5 g/kg respectively during 4 weeks. Female rats intoxicated with a dose of isoprenaline 30 mg/kg administered subcutaneously 24 hours before the experiment were used. ECG and blood pressure were measured using Mingograf Siemens-Elema at the beginning and during the experiment, while in 10 minutes intervals mediators of vegetative nervous system were intravenously given. We evaluated R wave height, frequency, PQ, QRS, QT and ST interval lenght and qualitatively ST interval depression or elevation, P wave absence and pathological Q wave occurrence.

Keywords: Toxicology; bile acids