AN APPRAISAL OF SINGLE ORGANS AND TISSUES LOADING AFTER XENOBIOTIC INVASION IN ORGANISM BY MEANS OF EXTRACTIONS POTENCIES CALCULATED USING FIRST PASS EFFECT (MODEL METHOTREXATE) IN RATS

V. Grossmann¹, J. Stuchlík¹, L. Šišpera², J. Martínková²: ¹ Department of research, development and clinics GALENA, a.s. IVAX-CR — Opava; ² Department of Pharmacology, Medicine Faculty of Charles University in Hradec Kralové

In the study of effect of New Chemical Entity (NCE) entering in organism it is advantageous to know the concentration of its loading the single organs and tissues. The greater stress is, the higher probability of undesirable effect and higher inﬂuence of pathologically changed organ function on effect kinetics and dosing can originate. The indicator of the stress degree can be the extraction potency (EP) of organ and tissues calculated using AUCS of plasma levels after administration of NCE in part of blood circuit before and after supplying the studied organ or area (2). Subtracting relation between these AUCS from one it is possible obtain the EP of studied organ (3)....

Keywords: Toxicology; New Chemical Entity

Published: December 2, 2001 Show citation

Grossmann, V., Stuchlík, J., Šišpera, L., & Martínková, J. (2001). AN APPRAISAL OF SINGLE ORGANS AND TISSUES LOADING AFTER XENOBIOTIC INVASION IN ORGANISM BY MEANS OF EXTRACTIONS POTENCIES CALCULATED USING FIRST PASS EFFECT (MODEL METHOTREXATE) IN RATS. Vojenské Zdravotnické Listy, 70(Suppl.2), 101

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