Since 1972 the former Institute for Immunology of Purkyne Military Medical Academy has been engaged in the study of pathogenesis of severe viral, rickettsial and bacterial infections. In the late eighties this Institute built laboratory for the analysis of complex protein mixtures originating from prokaryotic and eukaryotic cells that was based on the application of high-resolution two-dimensional gel electrophoresis (2-DE). Furthermore, the complete proteome "technology including computer-assisted 2-DE gel evaluation and MALDI-TOF MS for protein identification, was successfully implemented in 1999. In the year 2000 the Institute launched the tight cooperation with Faculty of Medicine of Charles University in Hradec Kralove and Masaryk Memorial Cancer Institute in Brno in order to perform the complex analysis of host-bacteria interactions on tissue, cellular; protein, and nucleic acid levels....

Keywords: Institute for Immunology of Purkyne Military Medical Academy