VZL 2005, 74(2):53-59

Domoic Acid - A Dangerous Neurotoxin

Vratislav Hrdina, Jiří Patočka ORCID...1,2, Vladimír Měrka, Radomír Hrdina3
1 Univerzita obrany, katedra toxikologie Fakulty vojenského zdravotnictví v Hradci Králové
2 Jihočeská univerzita, katedra radiologie a toxikologie Zdravotně sociální fakulty, České Budějovice
3 Univerzita Karlova, katedra farmakologie a toxikologie Farmaceutické fakulty v Hradci Králové

Kyselina domoová, aminokyselina produkovaná některými mikroskopickými organismy mořského planktonu, je příčinou toxicity některých mořských živočichů, zejména korýšů a měkkýšů. Jejich konzumace je příčinou kuriózních otrav doprovázených neurodegenerací a dysfunkcí CNS a v mnoha případech také ztrátou recentní (krátkodobé) paměti, což vede ke snížené nebo zcela vymizelé schopnosti osvojovat si a vybavovat nové poznatky. V práci jsou uvedeny základní informace o tomto podivuhodném mořském excitotoxinu.

Keywords: Kyselina domoová; Neurotoxin; Excitotoxin; Excitační aminokyselina; Intoxikace spojená s amnézií (ASP); NMDA-glutamátový receptor

Domoic acid, an amino acid produced by some microscopic algae and diatoms from the sea phytoplankton, causes toxicity in some sea animals, especially shellfish. Their consumption can cause curious intoxications combined with neurodegeneration and central nervous system dysfunction. In many cases a loss of recent memory occurs. It means a reduced capability or an absolute inability to remember new knowledge. Our study presents basic information on this strange excitotoxin.

Keywords: Domoic acid; Neurotoxin; Excitotoxin; Excitatory amino acid; Amnesic shellfish poisoning (ASP); NMDA-glutamic receptor

Received: March 25, 2005; Published: June 1, 2005  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Hrdina, V., Patočka, J., Měrka, V., & Hrdina, R. (2005). Domoic Acid - A Dangerous Neurotoxin. Vojenské Zdravotnické Listy, 74(2), 53-59
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. AMZIL, Z., et al. Domoic acid accumulation in French shellfish in relation to toxic species of Pseudonitzschia multiseries and P. pseudodelicatissima. Toxicon, 2001, vol. 39, p. 1245-1251. Go to original source... Go to PubMed...
    2. ANANTH, C., et al. Protective role of melatonin in domoic acid-induced neuronal damage in the hippocampus of adult rats. Hippocampus, 2003, vol. 13, p. 375-387. Go to original source... Go to PubMed...
    3. ANONYM. The problem of invaders in the Caspian Sea in the context of the findings of new zoo- and phytoplankton species from the Black Sea. [Article in Russian] Izv. Akad. Nauk Ser. Biol., 2005, issue 1, p. 78-87.
    4. APPEL, NM., et al. Sequelae of parenteral domoic acid administration in rats: comparison of effects on different metabolic markers in brain. Brain Res., 1997, vol. 754, p. 55-64. Go to original source... Go to PubMed...
    5. ARIAS, B., et al. In vivo release of dopamine and its metabolites from rat striatum in response to domoic acid. Neurochem. Res., 1998, vol. 23, p. 1509-1514. Go to original source... Go to PubMed...
    6. BAILEY, CH., et al. Toward a molecular definition of long-term memory storage. Proc. Nat. Acad. Sci. USA, 1996, vol. 93, p. 13445-13452. Go to original source... Go to PubMed...
    7. CENDES, F., et al. Temporal lobe epilepsy caused by domoic acid intoxication: evidence for glutamate receptor-mediated excitotoxicity in humans. Ann. Neurol., 1995, vol. 37, p. 123-126. Go to original source... Go to PubMed...
    8. CLAYTON, EC., et al. Working memory deficits induced by single but not repeated exposures to domoic acid. Toxicon., 1999, vol. 37, p. 1025-1039. Go to original source... Go to PubMed...
    9. COSTA, PR., et al. A potential vector of domoic acid: the swimming crab Polybius henslowii Leach (Decapodabrachyura). Toxicon, 2003, vol. 42, p. 135-141. Go to original source... Go to PubMed...
    10. CULOTTA, E. Red menace in the world's ocean. Science, 1992, vol. 257, p. 1476-1477. Go to original source... Go to PubMed...
    11. DAIGO, K. Studies on the constituents of Chondria armata. II. Isolation of an anthelmintical constituent. J. Jap. Pharm. Assoc., 1959, vol. 79, p. 353-356. Go to original source...
    12. DEBONEL, G., et al. Domoic acid, the alleged "mussel toxin", might produce its neurotoxic effect through kainate receptor activation: an electrophysiological study in the dorsal hippocampus. Can. J. Physiol. Pharmacol., 1989, vol. 67, p. 29-33. Go to original source... Go to PubMed...
    13. DOUCETTE, TA., et al. Low doses of domoic acid during postnatal development produce permanent changes in rat behaviour and hippocampal morphology. Neurotox Res. 2004, vol.6, p. 555-563. Go to original source... Go to PubMed...
    14. FALK, M., et al. Solubility of domoic acid in water and in nonaqueous solvents. Canad. J. Chem.-Rev. Can. Chim., 1991, vol. 69, p. 1740-1744. Go to original source...
    15. FUREY, A., et al. Determination of domoic acid in shellfish by liquid chromatography with electrospray ionization and multiple tandem mass spectrometry. J. Chromatogr. A., 2001, vol. 938, p. 167-174. Go to original source... Go to PubMed...
    16. GULLAND, FM., at al. Domoic acid toxicity in Californian sea lions (Zolophus californianus): clinical signs, treatment and survival. Vet. Rec. 2002, vol. 150, p. 475-480. Go to original source... Go to PubMed...
    17. HOLLAND, PT., et al. Amnesic shellfish poisoning toxins in shellfish: estimation of uncertainty of measurement for a liquid chromatography/tandem mass spectrometry method. J. AOAC Int. 2003, vol. 86, p.1095-1100. Go to original source... Go to PubMed...
    18. HRDINA, V., et al. Přírodní toxiny a jedy. Praha, Galén a Karolinum, 2004. 302 s.
    19. HUNGERFORD, JM. Committee on Natural Toxins and Food Allergens. Marine and freshwater toxins. J. AOAC Int., 2005, vol. 88, p. 299-313. Go to original source... Go to PubMed...
    20. IPCS. Poisons Information Monograph 670: Domoic acid. (May 1996). Available from: http://www.inchem.org/documents/pims/chemical/pim670.htm as of July 19, 2004.
    21. JEFFERY, B., et al. Amnesic shellfish poison. Food Chem. Toxicol., 2004, vol. 42, p. 545-557. Go to original source... Go to PubMed...
    22. JOHANSEN, TH., et al. A novel non-NMDA receptor antagonist shows selective displacement of low-affinity [3H]kainate binding. Eur. J. Pharmacol., 1993, vol. 246, p. 195-204. Go to original source... Go to PubMed...
    23. KLASSEN, CD. (ed). Casarett and Doull's Toxicology. The Basic Science of Poisons. 6th ed. New York, McGraw-Hill, 2001. 1079 p.
    24. KOTAKI, Y., et al. Confirmation of domoic acid production of Pseudonitzschia multiseries isolated from Ofunato Bay. Japan Toxicon., 1999, vol. 37, p. 677-682. Go to original source... Go to PubMed...
    25. KUNIG, G., et al. Regional differences in the interaction of excitotoxins domoate and L-beta-oxalyl-amino-alanine with [3H]-kainate binding sites in human hippocampus. Neurosci. Lett., 1995, vol. 187, p. 107-110. Go to original source... Go to PubMed...
    26. LARM, JA., et al. Neurotoxin domoic acid produces cytotoxicity via kainate- and AMPA-sensitive receptors in cultured cortical neurones. Neurochem. Int. 1997, vol. 31, p. 677-682. Go to original source... Go to PubMed...
    27. LI, DZ., et al. Capillary electrophoretic analysis of amnesic shellfish toxin-domoic acid [Article in Chinese] Se Pu, 2002, vol. 20, p.125-128.
    28. LOPEZ-RIVERA, A., et al. Improved high-performance liquid chromatographic method for the determination of domoic acid and analogues in shellfish: effect of pH. Anal. Bioanal. Chem., 2005, Mar 16; [Epub ahead of print] Go to original source... Go to PubMed...
    29. MAYER, AM. The marine toxin domoic acid may affect the developing brain by activation of neonatal microglia and subsequent neurotoxic mediator generation. Med. Hypotheses, 2000, vol. 54, p. 837-841. Go to original source... Go to PubMed...
    30. MICHELI, L., et al. Disposable immunosensor for the determination of domoic acid in shellfish. Biosens Bioelectron., 2004, vol. 20, p. 190-196. Go to original source... Go to PubMed...
    31. MOS, L. Domoic acid: a fascinating marine toxin. Environ. Toxicol. Pharmacol., 2001, vol. 9, p. 79-85. Go to original source... Go to PubMed...
    32. NAKAJIMA, S. - POTVIN, JL. Neural and behavioural effects of domoic acid, an amnesis shellfish toxin, in the rat. Can. J. Psychol., 1992, vol. 46, p. 569-581. Go to original source... Go to PubMed...
    33. NIEOULLON, A., et al. Excitotoxicity and the putative involvement of excitative amino acids in neurodegenerative diseases. J. Appl. Biomed., 2003, vol. 1, p. 1-5. Go to original source...
    34. NIJJAR, MS. - NIJJAR, SS. Domoic acid-induced neurodegeneration resulting in memory loss is mediated by Ca2+ overload and inhibition of Ca2+ + calmodulin-stimulated adenylate cyclase in rat brain (review). Int. J. Mol. Med., 2000, vol. 6, p. 377-389. Go to original source... Go to PubMed...
    35. NOVELLI, A., et al. Domoic acid-containing toxic mussels produce neurotoxicity in neuronal cultures through a synergism between excitatory amino acids. Brain Res. 1992, vol. 577, p. 41-48. Go to original source... Go to PubMed...
    36. OLNEY, JW. Excitotoxicity: an overview. Can. Dis. Wkly. Rep., 1990, vol. 16, suppl. 1, p. 47-57.
    37. PATOČKA, J. Kyselina domoová, neurotoxin způsobující ztrátu krátkodobé paměti. Psychiatrie, 1999, vol. 3, p. 182-184.
    38. PATOČKA, J. - STŘEDA, L. Brief review of natural nonprotein neurotoxins. ASA Newsletter, 2002, vol. 89, p. 16-24.
    39. PENG, YG. - RAMSDELL, JS. Brain Fos induction is a sensitive biomarker for the lowest observed neuroexcitatory effects of domoic acid. Fundam. Appl. Toxicol., 1996, vol. 31, p. 162-168. Go to original source... Go to PubMed...
    40. PERL, TM., et al. An outbreak of toxic encephalopathy caused by eating mussels contaminated with domoic acid. N. Engl. J. Med., 1990, vol. 322, p. 1775-1780. Go to original source... Go to PubMed...
    41. PERL, TM., et al. Amnesic shellfish poisoning: a new clinical syndrome due to domoic acid. Can. Dis. Wkly. Rep., 1990, vol. 16, suppl. 1, p. 7-8.
    42. QUILLIAM, MA. Phycotoxins. J. AOAC Int., 1999, vol. 82, p. 773-781. Go to original source... Go to PubMed...
    43. QUILLIAM, MA., et al. Analysis of domoic acid in shellfish by thin-layer chromatography. Nat. Toxins, 1998, vol. 6, p. 147-152. Go to original source... Go to PubMed...
    44. RHODES, L., et al. Pseudonitzschia in New Zealand and the role of DNA probes and immunoassays in refining marine biotoxin monitoring programmes. Nat. Toxins, 1998, vol. 6, p. 105-111. Go to original source... Go to PubMed...
    45. SCHOLIN, CA., et al. Mortality of sea lions along the central California coast linked to a toxic diatom bloom. Nature, 2000, vol. 403, p. 80-84. Go to original source... Go to PubMed...
    46. SIERRA-BELTRAN, A., et al. Sea bird mortality at Cabo San Lucas, Mexico: evidence that toxic diatom blooms are spreading. Toxicon, 1997, vol. 35, p. 447-453. Go to original source... Go to PubMed...
    47. SILVAGNI, PA., et al. Pathology of domoic acid toxicity in California sea lions (Zolophus californianus). Vet. Pathol., 2005, vol. 42, p. 184-191. Go to original source... Go to PubMed...
    48. SLIKKER, W., et al. Biologically-based dose-response model for neurotoxicity risk assessment. Toxicol. Lett., 1998, vol. 102, 429-433. Go to original source... Go to PubMed...
    49. SMAYDA, TJ. - SHIMIZU, Y. (eds.) Toxic Phytoplankton Blooms in the Sea. New York, Elsevier Sci. Publ., 1993.
    50. SPENCER, PS., et al. Are human neurodegenerative disorders linked to environmental chemicals with excitotoxic properties? Ann. N. Y. Acad. Sci., 1992, vol., 648, p. 154-160. Go to original source... Go to PubMed...
    51. STEWART, JM., et al. Microbial utilization of the neurotoxin domoic acid: blue mussels (Mytilus edulis) and soft shell clams (Mya arenaria) as source of the microorganisms. Can. J. Microbiol., 1998, vol. 44, p. 456-464. Go to original source... Go to PubMed...
    52. STOMMEL, EW. - WATTERS, MR. Marine Neurotoxins: Ingestible Toxins. Curr. Treat. Options Neurol., 2004, vol. 6, p. 105-114. Go to original source... Go to PubMed...
    53. TAKEMOTO, T. - DAIGO, K. Constituents of Chondria armata. Chem. Pharm. Bull., 1958, vol. 6, p. 578-580. Go to original source...
    54. TASKER, RA., et al. Selective reduction in domoic acid toxicity in vivo by a novel non-N-methyl-D-aspartate receptor antagonist. Can. J. Physiol. Pharmacol., 1996, vol. 74, p. 1047-1054. Go to original source... Go to PubMed...
    55. TEITELBAUM, JS., et al. Neurologic sequelae of domoic acid intoxication due to the ingestion of contaminated mussels. New England J. Med., 1990, vol. 322, p. 1781-1787. Go to original source... Go to PubMed...
    56. TOSTESON, TR. The diversity and origins of toxins in ciguatera fish poisoning. P. R. Health Sci. J., 1995, vol. 14, p. 117-129. Go to PubMed...
    57. WALZ, PM., et al. Domoic acid producing diatom blooms in Monterey Bay, California; 1991-93. Natural Toxins, 1994, vol. 2, p. 271-279. Go to original source... Go to PubMed...
    58. WANG, JK. Presynaptic glutamate receptors modulate dopamine release from striatal synaptosomes. J. Neurochem., 1991, vol. 57, p. 819-822. Go to original source... Go to PubMed...
    59. WORK, TM., et al. Domoic acid intoxication of brown pelicans and cormorants in Santa Cruz, California. In SMAYDA, TJ., et al. Domoic acid is a potent neurotoxin to neonatal rats. Nat. Toxin, 1997, vol. 5, p. 74-79. Go to original source...
    60. WRIGHT, JLC. Domoic acid - ten years after. Nat. Toxins, 1998, vol. 6, p. 91-92. Go to original source... Go to PubMed...
    61. XI, D., et al. Domoic acid is a potent neurotoxin to neonatal rats. Nat. Toxins, 1997, vol. 5, p. 74-79. Go to original source... Go to PubMed...
    62. YU, FY., et al. Development of a sensitive enzyme-linked immunosorbent assay for the determination of domoic acid in shellfish. J. Agric. Food Chem., 2004, vol. 52, p. 5334-5339. Go to original source... Go to PubMed...

    Return to the content