VZL 2005, 74(2):81-84

Biodosimetry Part I: Practical Need of Biodosimetry and the Most Important Mechanisms Activated After Irradiation

Zdeňka Vilasová, Jan Österreicher, Jiřina Vávrová
Univerzita obrany, katedra radiobiologie Fakulty vojenského zdravotnictví v Hradci Králové

Práce pojednává o možnostech praktického použití současných metod biodozimetrie včetně informací o jejich omezeních. V další části obsahuje ucelené shrnutí nejdůležitějších poznatků účinků ionizujícího záření na molekulární úrovni, zejména pak postradiační aktivace p53, navození bloku v G2/M buněčného cyklu a související aktivace MAP-kinázové cesty.

Keywords: Biodozimetrie; p53; G2, M blok; MAPK

This study analyzes possibilities of the use of biodosimetric methods in military practice. It also mentions information concerning limited use of these methods. Subsequently it contains a summary of the most important facts concerning radiation-induced mechanisms at the molecular level, in paticular those concerning p53 activation, induction of G2/M cell cycle arrest and related activation of the MAP kinase pathway at the molecular level.

Keywords: Biodosimetry; p53; G2/M block; MAPK

Received: October 19, 2004; Published: June 1, 2005  Show citation

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Vilasová, Z., Österreicher, J., & Vávrová, J. (2005). Biodosimetry Part I: Practical Need of Biodosimetry and the Most Important Mechanisms Activated After Irradiation. Vojenské Zdravotnické Listy, 74(2), 81-84
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