VZL 2007, 76(1):7-11

Global Quality of Life in Adult Patients with Acute Myeloid Leukemia after Haematopoietic Stem Cell Transplantation: Cross-Sectional and Retrospective Study

Ladislav Slováček1,2, Birgita Slováčková3, Ladislav Jebavý1,2
1 Katedra válečného vnitřního lékařství Fakulty vojenského zdravotnictví, Univerzita obrany, Hradec Králové
2 Oddělení klinické hematologie II. interní kliniky Fakultní nemocnice a Lékařské fakulty Univerzity Karlovy v Hradci Králové
3 Psychiatrická klinika Fakultní nemocnice a Lékařské fakulty Univerzity Karlovy v Hradci Králové

Transplantace krvetvorných buněk je specifická léčebná metoda užívaná nejen v léčbě hematologických malignit a solidních tumorů, ale i v léčbě nenádorových onemocnění. Podobně jako jiné léčebné metody také transplantace krvetvorných buněk ovlivňuje další průběh onemocnění a tím i kvalitu života nemocného. Autoři ve své transverzální studii s 12 dospělými pacienty s akutní myeloidní leukémií po transplantaci krvetvorných buněk na Oddělení klinické hematologie II. interní kliniky Fakultní nemocnice a Lékařské fakulty UK v Hradci Králové analyzují vliv vybraných faktorů na globální kvalitu života u této skupiny nemocných. Metodikou European Quality of Life Questionnaire EQ-5D je hodnocena globální kvalita života v závislosti na věku, pohlaví, úrovni vzdělání, polymorbiditě, religiozitě, rodinném stavu, abuzu kouření, typu transplantace krvetvorných buněk (alogenní/autologní) a časovém odstupu od provedení transplantace krvetvorných buněk. Výsledky prezentují statisticky významnou závislost globální kvality života na věku, religiozitě, abuzu kouření, vzdělání a polymorbiditě. Vliv ostatních faktorů se jako statistický významný neprokázal. Globální kvalita života dospělých nemocných s akutní myeloidní leukémií po transplantaci krvetvorných buněk na Oddělení klinické hematologie II. interní kliniky FN a LF UK v Hradci Králové je na velmi dobré úrovni, o čemž vypovídají i průměrné hodnoty EQ-5D skóre (75,1 %) a EQ-5D VAS (67,5 %).

Keywords: Kvalita života; Akutní myeloidní leukémie; Transplantace krvetvorných buněk; Dotazníky kvality života

The haematopoietic stem cell transplantation is a specific therapy used not only in the therapy of haemato-oncological disease and in the therapy of solid tumors but also in the therapy of non-malignant diseases. As other currative methods, the haematopoetic stem cell transplantation has an influence on the course of disease and consequently on the quality of life. The authors explore the global quality of life in 12 adult patients with acute myeloid leukemia after haematopoietic stem cell transplantation at the Department of Clinical Haematology of the 2nd Department of Internal Medicine, University Hospital and the Faculty of Medicine of Charles University in Hradec Králové. The EuroQol methodology (European Quality of Life Questionnaire EQ-5D) was used in evaluating the effects of selected aspects on the global quality of life (age, sex, level of education, religion, smoking abuse, polymorbidity, marital status, type of transplantation (autologous or allogeneic) and the lapse time from transplantation. The results show that the global quality of life is significantly related with the age, level of education, smoking abuse, religion and polymorbidity. The effect of other factors on the global quality of life has not been proved. The global quality of life in adult patients wih acute myeloid leukemia after the haematopoietic stem cell transplantation at the Department of Clinical Haematology of the 2nd Department of Internal Medicine, University Hospital and the Faculty of Medicine of Charles University in Hradec Králové is on a greatly good level (mean EQ-5D score was 75,1% and mean EQ-5D VAS was 67,5%).

Keywords: Quality of life; Acute myeloid leukemia; Haematopoietic stem cell transplantation; Quality of life questionnaire

Received: May 16, 2006; Published: March 1, 2007  Show citation

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Slováček, L., Slováčková, B., & Jebavý, L. (2007). Global Quality of Life in Adult Patients with Acute Myeloid Leukemia after Haematopoietic Stem Cell Transplantation: Cross-Sectional and Retrospective Study. Vojenské Zdravotnické Listy, 76(1), 7-11
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