VZL 2007, 76(1):27-31

A Comparison of Newly Synthesized Oximes (K074, K075) and Oximes Introduced into the Czech Army (Obidoxime, HI-6) to Reactivate Tabun or Soman-Inhibited Acetylcholinesterase in Rat's Blood and Brain

Jiří Kassa ORCID...1, Daniel Jun ORCID...2
1 Katedra toxikologie Fakulty vojenského zdravotnictví, Univerzita obrany, Hradec Králové
2 Centrum pokročilých studií Fakulty vojenského zdravotnictví, Univerzita obrany, Hradec Králové

Na samcích potkana kmene Wistar byl testován reaktivační účinek nově syntetizovaných oximů (K074, K075) a srovnáván s reaktivačním efektem oximů zavedených do zdravotnické výbavy AČR jako antidotum první pomoci (obidoxim) či lékařské pomoci (HI-6). Schopnost oximů reaktivovat tabunem nebo somanem inhibovanou acetylcholinesterázu byla hodnocena cestou srovnání aktivity acetylcholinesterázy v krvi a mozku potkana měřené 30 minut po otravě tabunem nebo somanem. Získané výsledky ukázaly, že nově syntetizované oximy jsou účinnějšími reaktivátory tabunem inhibované mozkové acetylcholinesterázy než dosud používané oximy, avšak v případě otravy somanem nedosahují reaktivačního efektu oximu HI-6.

Keywords: Tabun; Soman; Acetylcholinesteráza; HI-6; Obidoxim; K074; K075; Atropin; Potkan

The reactivating efficacy of newly synthesized oximes (K074, K075) and the oximes introduced into the Czech Army for the first aid (obidoxime) and medical care (HI-6) was evaluated in male Wistar rats. The potency of oximes to reactivate tabun or soman-inhibited acetylcholinesterase was evaluated by the comparison of the activity of acetylcholinesterase in rat's blood and brain measured 30 minutes following tabun or soman poisoning. The obtained results demonstrate that newly synthesized oximes are more effective than currently used oximes in the reactivation of tabun-inhibited brain acetylcholinesterase but less effective than the oxime HI-6 against soman.

Keywords: Tabun; Soman; Acetylcholinesterase; HI-6; Obidoxime; K074; K075; Atropine; Rat

Received: August 3, 2006; Published: March 1, 2007  Show citation

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Kassa, J., & Jun, D. (2007). A Comparison of Newly Synthesized Oximes (K074, K075) and Oximes Introduced into the Czech Army (Obidoxime, HI-6) to Reactivate Tabun or Soman-Inhibited Acetylcholinesterase in Rat's Blood and Brain. Vojenské Zdravotnické Listy, 76(1), 27-31
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