VZL 2007, 76(3):95-104

Biodosimetry: Dicentric Analysis and Premature Chromosome Condensation (PCC)

Jaroslav Pejchal ORCID..., Jan Österreicher, Jiřina Vávrová
Univerzita obrany, katedra radiobiologie Fakulty vojenského zdravotnictví, Hradec Králové

Nedávné události po celém světě poukazují na vzrůstající nebezpečí různých forem terorismu, včetně radiologického nebo nukleárního terorismu. Metody fyzikální dozimetrie jsou mnohdy nespolehlivé či nejsou využívány vůbec. Proto jsou zapotřebí metody, které by přesně určily absorbovanou dávku a pomohly při třídění ozářených pacientů. Cytogenetické metody jsou dosud nejpoužívanějšími metodami biologické dozimetrie. Práce pojednává o cytogenetických metodách - dicentrické analýze a předčasné chromozomové kondenzaci (PCC). Hodnotí tyto metody a srovnává jejich přednosti a nedostatky.

Keywords: Biodozimetrie; Dicentrická analýza; PCC

Current events throughout the world underscore the growing threat of different forms of terrorism, including a radiological or a nuclear attack. Physical dosimetric methods have sometimes low validity or are not used at all. Therefore, methods for accurate estismation of absorbed doses to facilitate effective triage are needed. Cytogenetic methods are the most widely used methods in biological dozimetry. The work analyses cytogenetic methods - dicentric analysis and premature chromosome condensation (PCC). The work assesses these methods and compares their advantages and disadvantages.

Keywords: Biodosimetry; Dicentric analysis; PCC

Received: January 17, 2007; Published: September 1, 2007  Show citation

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Pejchal, J., Österreicher, J., & Vávrová, J. (2007). Biodosimetry: Dicentric Analysis and Premature Chromosome Condensation (PCC). Vojenské Zdravotnické Listy, 76(3), 95-104
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