VZL 2008, 77(2):58-65

New Potentialities of Passive Immunoprophylaxis of Bacterial Intracellular Infections

Klára Kubelková ORCID...1, Aleš Macela ORCID...2
1 Univerzita obrany, Ústav molekulární patologie Fakulty vojenského zdravotnictví, Hradec Králové
2 Univerzita obrany, Centrum pokročilých studií Fakulty vojenského zdravotnictví, Hradec Králové

Infekce způsobené intracelulárními bakteriálními patogeny jsou považovány obecně za vážný problém veřejného zdravotnictví. Vzhledem k neexistenci vakcín pro humánní použití neexistuje u většiny infekcí ani žádná vakcinační strategie. Informace získané z nových studií nabízejí možnost využití polyklonálních nebo monoklonálních protilátek samotných či v kombinaci s cytokiny k pasivní imunoprofylaxi těchto závažných infekčních onemocnění.

Keywords: Protilátky; Bakteriální infekce; Intracelulární bakterie; Protektivní imunita; Pasivní přenos; Cytokiny

Infections caused by intracellular bacterial pathogens are generally considered as a serious problem for health care services. The vaccination strategy is missing in most of these infections due to the absence of vaccines licensed for human use. The information from newly performed studies revealed the possibility of utilizing the polyclonal or monoclonal antibodies alone, or in combination with cytokines as a tool for passive immunoprophylaxis of these serious infections.

Keywords: Antibodies; Bacterial infection; Intracellular bacterium; Protective immunity; Passive transfer; Cytokines

Received: January 24, 2008; Published: June 1, 2008  Show citation

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Kubelková, K., & Macela, A. (2008). New Potentialities of Passive Immunoprophylaxis of Bacterial Intracellular Infections. Vojenské Zdravotnické Listy, 77(2), 58-65
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