VZL 2009, 78(2):60-65

Protection of Brain Acetylcholinesterase against Inhibition with VX Agent in Laboratory Rats

Jiří Bajgar
Univerzita obrany, Fakulta vojenského zdravotnictví, katedra toxikologie, Hradec Králové

Byl studován ochranný účinek reverzibilních inhibitorů cholinesteráz tacrinu a pyridostigminu samotných nebo jejich kombinací s různými látkami proti inhibici acetylcholinesterázy v pontomedulární oblasti nebo mozečku potkanů způsobenou látkou VX in vivo, stejně jako přežívání zvířat premedikovaných různými kombinacemi použitých látek. Nejlepší profylaktický efekt byl pozorován pro kombinaci pyridostigminu (nebo tacrinu) s benactyzinem, trihexyfenidylem a HI-6. Samotný tacrin nebo i jeho různé kombinace nebyly lepší než pyridostigmin.

Keywords: Benactyzin; Trihexyfenidyl; HI-6; Tacrin; VX; Potkan; Profylaxe; Acetylcholinesteráza; Mozeček; pontomedulární oblast

Protective effect of cholinesterase reversible inhibitors tacrin, and pyridostigmine alone or in combination with different drugs against acetylcholinesterase inhibition in the pontomedullar area and cerebellum of rats caused by VX agent in vivo was studied as well as survival of animals pretreated with different combinations of the drugs used. The best prophylactic effect was observed for combination of pyridostigmine (or tacrin) with benactyzine, trihexyphenidyle and HI-6. However, tacrine alone or in other combinations had not better prophylactic effect in comparison with these combinations containing pyridostigmine.

Keywords: Benactyzine; Trihexyphenidyle; HI-6; Tacrin; VX; Rat; Prophylaxis; Acetylcholinesterase; Cerebellum; pontomedullar area

Received: February 14, 2008; Published: June 1, 2009  Show citation

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Bajgar, J. (2009). Protection of Brain Acetylcholinesterase against Inhibition with VX Agent in Laboratory Rats. Vojenské Zdravotnické Listy, 78(2), 60-65
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