MMSL 2017, 86(2):70-83 | DOI: 10.31482/mmsl.2017.011

HLö-7 - A REVIEW OF ACETYLCHOLINESTERASE REACTIVATOR AGAINST ORGANOPHOSPHOROUS INTOXICATIONReview article

Miroslav Psotka1, David Maliňák1, Lukáš Gorecki ORCID...1,2, Thuy Duong Nguyen ORCID...2, Ondřej Soukup ORCID...1,2, Daniel Jun ORCID...1,2, Kamil Kuča ORCID...1, Kamil Musílek ORCID...1,2, Jan Korábečný ORCID...1,2*
1 Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic
2 Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic

The treatment of organophosphate (OP) poisoning consists of the administration of a parasympatholytic agent, an anticonvulsant and an acetylcholinesterase (AChE) reactivator. Since there is no broad AChE reactivator available, a post-treatment strategy currently exploits administration of different types of oximes depending on the exposure of OP. In this contribution, we summarize all the available data about AChE reactivator HLö-7 including its synthesis, physico-chemical properties, pharmacokinetic and pharmacodynamics profile, and its efficacy in vitro and in vitro.

Keywords: Acetylcholinesterase; Organophosphorus compound; Oximes; Nerve agent; Reactivation; Hlö-7

Received: February 2, 2017; Revised: May 22, 2017; Published: June 9, 2017  Show citation

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Psotka, M., Maliňák, D., Gorecki, L., Nguyen, T.D., Soukup, O., Jun, D., ... Korábečný, J. (2017). HLö-7 - A REVIEW OF ACETYLCHOLINESTERASE REACTIVATOR AGAINST ORGANOPHOSPHOROUS INTOXICATION. MMSL, 86(2), 70-83. doi: 10.31482/mmsl.2017.011
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