MMSL 2017, 86(3):122-134 | DOI: 10.31482/mmsl.2017.020

PHARMACOLOGICALLY AND TOXICOLOGICALLY RELEVANT COMPONENTS OF Amanita muscariaReview article

Jiří Patočka ORCID...*, Barbora Kocandrlová
Institute of Radiology, Toxicology and Civil Protection, Faculty of Health and Social Studies, University of South Bohemia České Budějovice, České Budějovice, Czech Republic

Amanita muscaria, the red fly agaric, is the most famous of all Amanita. The initial history of this fascinating mushroom dates back to at least the 13th century. The use of mushrooms began in antiquity and is associated with mysticism. The collection and consumption of mushrooms and other plants containing psychoactive substances is now very popular, especially among young people who are experimenting with drugs. Ibotenic acid and muscimol are the main active ingredients of this mushroom, but other substances are likely to be involved in the psychotropic effects. A. muscaria also contains some other non-psychotropic substances that are interesting not only for their chemical structure but also for their biological activity. Current knowledge about chemistry, pharmacology and toxicology regarding this fungus is reviewed in this article.

Keywords: Amanita muscaria; fly agaric; ibotenic acid; muscimol; stizolobic acid; muscarufine; betalains

Received: July 14, 2017; Revised: August 15, 2017; Published: September 8, 2017  Show citation

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Patočka, J., & Kocandrlová, B. (2017). PHARMACOLOGICALLY AND TOXICOLOGICALLY RELEVANT COMPONENTS OF Amanita muscaria. MMSL, 86(3), 122-134. doi: 10.31482/mmsl.2017.020
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