MMSL 2018, 87(1):14-20 | DOI: 10.31482/mmsl.2018.003

BOLESATINE, A TOXIC PROTEIN FROM THE MUSHROOM RUBROBOLETUS SATANASReview article

Jiří Patočka ORCID...1,2
1 Institute of Radiology, Toxicology and Civil Protection, Faculty of Health and Social Studies, University of South Bohemia České Budějovice, České Budějovice, Czech Republic
2 Biomedical Research Centre, University Hospital, Hradec Kralove, Czech Republic

Rubroboletus satanas (Lenz) Kuan Zhao & Zhu L. Yang, known as Boletus satanas (Lenz) until 2014, and commonly known as the Devil´s bolete or Satan´s bolete, is a basidiomycete mushroom of the bolete family. Grows in mixed woodlands in the southern, warmer regions of Europe and North America. Satan´s bolete generally regarded as a poisonous mushroom, with predominantly gastrointestinal symptoms of nausea and violent vomiting occurring if eaten raw or isufficiently heat-treated. The toxicity of the mushroom corresponds to a toxic protein called bolesatine. Bolesatine is a toxic glycoprotein which has been shown to inhibit protein synthesis in cell-free systems and cell culture and is toxic to rodents. Biology, chemistry, pharmacology and toxicology of bolesatine is discussed in this article.

Keywords: Rubroboletus satanas; Boletus satanas; poisoning mushroom; toxic peptide; bolesatine

Received: October 3, 2017; Revised: November 22, 2017; Published: March 9, 2018  Show citation

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Patočka, J. (2018). BOLESATINE, A TOXIC PROTEIN FROM THE MUSHROOM RUBROBOLETUS SATANAS. MMSL, 87(1), 14-20. doi: 10.31482/mmsl.2018.003
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