Nerve Agents are toxic organophosphorus compounds which inhibit cholinesterases, pivotal enzyme in Parasympathetic Neurotransmission. As they are Schedule 1 compounds in accordance to Chemical Weapons Convention, strict controls are applied and some research groups may have their work hampered due to requirements for synthesis and manipulation. Nerve Agents’ surrogates have emerged as affordable substitutes for more realistic approach for development of antidotes and biochemical and toxicity studies, as they are structurally related to Nerve Agents and considered as CWC Schedule 2 compounds, yielding similar enzyme adducts. As Laboratório de Análises Químicas – LAQ (ISO 17025) at IDQBRN have been participated in OPCW Proficiency Tests, striven to obtain the “OPCW Designated Laboratory” status, we have synthesized different dialkyl alkylphosphonates for verification purposes. Therefore, we have proposed synthesis of surrogates for our research on Medicinal Chemistry using them as starting materials. They have proven to be very useful compounds in our research and our syntheses have delivered good yields and purity of final compounds.

Keywords: Nerve Agents’ Surrogates; Chemical Weapons Convention; Cholinesterases; Drug Screening; Dialkyl Alkylphosphonates