MMSL 2019, 88(2):51-53 | DOI: 10.31482/mmsl.2018.045

EVIDENCE-BASED TOXICOLOGY: WHERE DOES IT GO?Review article

Jiri Patocka ORCID...1,2
1 Institute of Radiology, Toxicology and Civil Protection, Faculty of Health and Social Studies, University of South Bohemia Èeské Budìjovice, Èeské Budìjovice, Czech Republic
2 Biomedical Research Centre, University Hospital, Hradec Králové, Czech Republic

Evidence-Based Toxicology (EBT) was established in 2005 as a tool for toxicological risk assessment and causal link on the basis of the parallel relationship between the toxicological test method evaluation and the Evidence-Based Diagnostic Testing Assessment (EBM). The introduction of evidence-based principles can provide new tools that are necessary to validate toxicological testing methods. EBT should contribute to testing strategies to address toxicology problems in the 21st century. Practice has shown that the underlying concepts of EBT, such as the use of systematic reviews to capture and consider all available information, improve the results of toxicological assessment conducted by different groups and orga-nizations. New challenges are emerging before toxicology, such as safety assessments of new agrochemicals, pharmaceuticals and nanomaterials, and EBT can provide important results for their application in practice.

Keywords: Evidence-based toxicology (EBT); causation; environmental health

Received: July 17, 2018; Accepted: December 11, 2018; Prepublished online: February 25, 2019; Published: June 7, 2019  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Patocka, J. (2019). EVIDENCE-BASED TOXICOLOGY: WHERE DOES IT GO? MMSL, 88(2), 51-53. doi: 10.31482/mmsl.2018.045
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Eddy DM. Evidence-Based Medicine: A Unified Approach. Health Aff. 2005;24(1):9-17. Go to original source... Go to PubMed...
    2. Guzelian PS, Victoroff MS, Halmes NC, James RC, Guzelian CP. Evidence-based toxicology: a comprehensive framework for causation. Hum Exp Toxicol. 2005;24(4):161-201. Go to original source... Go to PubMed...
    3. Hartung T. Evidence-based toxicology - the toolbox of validation for the 21st century? ALTEX. 2010;27(4):253-263. Go to original source... Go to PubMed...
    4. Hartung T, Fitzgerald RE, Jennings P, Mirams GR, Peitsch MC, Rostami-Hodjegan A, Shah I, Wilks MF, Sturla SJ. (2017). Systems toxicology: Real world applications and opportunities. Chem Res Toxicol. 2017;30(4),870-882. Go to original source... Go to PubMed...
    5. Hoffmann S, Hartung T. Diagnosis: toxic! Trying to apply approaches of clinical diagnostics and prevalence in toxicology considerations. Toxicol Sci. 2005;85:422-428. Go to original source... Go to PubMed...
    6. Hoffmann S, Hartung T. Toward an evidence-based toxicology. Hum Exp Toxicol. 2006;25(9):497-513. Go to original source... Go to PubMed...
    7. Mandrioli D, Silbergeld E. Evidence from toxicology: the most essential science for the prevention. Environ Health Perspect. 2016;124:6-11. Go to original source... Go to PubMed...
    8. Rudén C, Hansson SO. Evidence-based toxicology: "sound science" in new disguise. Int J Occup Environ Health. 2008;14(4):299-306. Go to original source... Go to PubMed...
    9. Stephens M, Andersen M, Becker RA, Betts K et al. (2013). Evidence-based toxicology for the 21st century: Opportunities and challenges. ALTEX. 2013;30(1):74-104. Go to original source... Go to PubMed...
    10. Stephens ML, Betts K, Beck NB, Cogliano V, Dickersin K, Fitzpatrick S, Freeman J, Gray G, Hartung T, McPartland J, Rooney AA, Scherer RW, Verloo D, Hoffmann S. The Emergence of Systematic Review in Toxicology. Toxicol Sci. 2016;152(1):10-16. Go to original source... Go to PubMed...
    11. Valerio LG, Jr. In silico models and databases as FDA critical path initiative toolkits. Jum Genomics 2011;5(3):200-207. Go to original source... Go to PubMed...
    12. Von Aulock S. Evidence-Based Toxicology Collaboration (EBTC). Editorial. ALTEX. 2013;30(1):1. Go to PubMed...
    13. Wikoff DS, Miller GW. Systematic Reviews in Toxicology. Toxicological Sciences, 2018;163(2),335-337. Go to original source... Go to PubMed...

    Return to the content