MMSL 2020, 89(3):114-125 | DOI: 10.31482/mmsl.2020.008

GUT MICROBIOTA ALTERATIONS BY NUTRITIONAL SUPPLEMENT IMUREGENOriginal article

Klara Kubelkova ORCID...1*, Ivan Rychlik2, Magdalena Crhanova2, Daniela Karasova2, Dasa Slizova3, Jitka Zakova1, Lenka Luksikova1, Ales Macela1
1 Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic
2 Veterinary Research Institute, Brno, Czech Republic
3 Charles University, Faculty of Medicine in Hradec Kralove, Czech Republic

The gut microbiota is one of the modulators influencing its host’s development, metabolism, as well as immunological, psychological, and cognitive abilities. The gut microbiota consortium influences enteroendocrine regulation, neurohormonal regulation, as well as natural immune regulation. Disruptions occurring in life can lead to dysbiosis that in turn influences the host homeostasis and/or disease. Targeted modulation of microbiota composition thus appears to be an appropriate intervention strategy in cases of certain specific health problems. Here, we demonstrate that application of the nutritional supplement Imuregen, which is a natural immune booster, modulates the Bacteroidetes/Firmicutes ratio in favor of the Bacteroidetes genera and causes no pathological changes to intestinal epithelium.

Keywords: microbiome; microbiota; Imuregen; immune modulation

Received: January 22, 2020; Revised: March 6, 2020; Accepted: March 12, 2020; Prepublished online: March 30, 2020; Published: September 4, 2020  Show citation

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Kubelkova, K., Rychlik, I., Crhanova, M., Karasova, D., Slizova, D., Zakova, J., Luksikova, L., & Macela, A. (2020). GUT MICROBIOTA ALTERATIONS BY NUTRITIONAL SUPPLEMENT IMUREGEN. MMSL, 89(3), 114-125. doi: 10.31482/mmsl.2020.008
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