MMSL 2022, 91(1):37-43 | DOI: 10.31482/mmsl.2021.027
OVERVIEW OF VITAMIN D ROLE IN POLYCYSTIC OVARIAN SYNDROMEReview article
- Department of Pharmacology and Toxicology, College of Pharmacy, University of Mosul, Mosul, Iraq
Vitamin D inadequacy is widespread in females with polycystic ovarian syndrome (PCOS), with blood values of 25-hydroxy vitamin D (25OHD) down to or less than 20 ng/ml in two-third of PCOS patients. Decreased 25OHD concentrations have been linked to insulin resistance, ovulatory and period abnormalities, lower pregnancy outcomes, and other indications of PCOS, according to epidemiological studies. There might be some, but inadequate, research that vitamin D supplements can help women with PCOS with menstruation disruption and insulin sensitivity. Vitamin D inadequacy may bestow to the exacerbation of PCOS, and vitamin D intake may be helpful in the treatment of this condition. However, the present evidence is insufficient, and further experimental investigations are in need to establish vitamin D supplementation's potential advantages in this population. Many investigators claimed a pertinency between vitamin D concentrations and PCOS, nevertheless, these researches bear rattle factors of conjoined with other disorders or ailments, such as obesity, diabetes, and hirsutism. In the view of this, the present review detailed the role of vitamin D inadequacy and related biomolecule abnormalities, including sex hormones, and insulin and we listed their psychological and cardiovascular encounter. We concluded that the correlation between vitamin D intake and mended PCOS prominence is dubious and no definite findings attained by studies conducted across multicentral laboratories.
Keywords: PCOS; Vitamin D; Calcium; Androgen; Reproduction
Received: August 8, 2021; Revised: September 17, 2021; Accepted: September 20, 2021; Prepublished online: December 21, 2021; Published: March 4, 2022 Show citation
References
- March WA, Moore VM, Willson KJ, et al. The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria. Hum Reprod. 2010;25(2):544-51.
Go to original source...
Go to PubMed...
- Lam PM, Johnson IR, Raine-Fenning NJ. Three-dimensional ultrasound features of the polycystic ovary and the effect of different phenotypic expressions on these parameters. Hum Reprod. 2007;22(12):3116-23.
Go to original source...
Go to PubMed...
- Talbott EO, Zborowski J V., Boudreaux MY. Do women with polycystic ovary syndrome have an increased risk of cardiovascular disease: Review of the evidence. Int Congr Ser. 2004;1266(C):233-40.
Go to original source...
- Ramagopalan S V., Heger A, Berlanga AJ, et al. A ChIP-seq defined genome-wide map of vitamin D receptor binding: Associations with disease and evolution. Genome Res. 2010;20(10):1352-60.
Go to original source...
Go to PubMed...
- Thomson RL, Spedding S, Buckley JD. Vitamin D in the aetiology and management of polycystic ovary syndrome. Clin Endocrinol (Oxf). 2012;77(3):343-50.
Go to original source...
Go to PubMed...
- Panidis D, Balaris C, Farmakiotis D, et al. Serum parathyroid hormone concentrations are increased in women with polycystic ovary syndrome. Clin Chem. 2005;51(9):1691-7.
Go to original source...
Go to PubMed...
- Hahn S, Haselhorst U, Tan S, et al. Low serum 25-hydroxyvitamin D concentrations are associated with insulin resistance and obesity in women with polycystic ovary syndrome. Exp Clin Endocrinol Diabetes. 2006;114(10):577-83.
Go to original source...
Go to PubMed...
- Yildizhan R, Kurdoglu M, Adali E, et al. Serum 25-hydroxyvitamin D concentrations in obese and non-obese women with polycystic ovary syndrome. Arch Gynecol Obstet. 2009;280(4):559-63.
Go to original source...
Go to PubMed...
- Wehr E, Pilz S, Schweighofer N, et al. Association of hypovitaminosis D with metabolic disturbances in polycystic ovary syndrome. Eur J Endocrinol. 2009;161(4):575-82.
Go to original source...
Go to PubMed...
- Li HWR, Brereton RE, Anderson RA, et al. Vitamin D deficiency is common and associated with metabolic risk factors in patients with polycystic ovary syndrome. Metabolism [Internet]. 2011;60(10):1475-81. Available from: http://dx.doi.org/10.1016/j.metabol.2011.03.002
Go to original source...
Go to PubMed...
- Wehr E, Pieber TR, Obermayer-Pietsch B. Effect of vitamin D3 treatment on glucose metabolism and menstrual frequency in polycystic ovary syndrome women: A pilot study. J Endocrinol Invest. 2011;34(10):757-63.
Go to PubMed...
- Mazloomi S, Sharifi F, Hajihosseini R, et al. Association between Hypoadiponectinemia and Low Serum Concentrations of Calcium and Vitamin D in Women with Polycystic Ovary Syndrome. ISRN Endocrinol. 2012;2012:1-6.
Go to original source...
Go to PubMed...
- Lerchbaum E, Giuliani A, Gruber HJ, et al. Adult-type hypolactasia and calcium intake in polycystic ovary syndrome. Clin Endocrinol (Oxf). 2012;77(6):834-43.
Go to original source...
Go to PubMed...
- Mahmoudi T, Gourabi H, Ashrafi M, et al. Calciotropic hormones, insulin resistance, and the polycystic ovary syndrome. Fertil Steril [Internet]. 2010;93(4):1208-14. Available from: http://dx.doi.org/10.1016/j.fertnstert.2008.11.031
Go to original source...
Go to PubMed...
- Prentice A. Vitamin D deficiency: A global perspective. Nutr Rev. 2008;66(SUPPL.2):153-64.
Go to original source...
Go to PubMed...
- Lips P. Worldwide status of vitamin D nutrition. J Steroid Biochem Mol Biol [Internet]. 2010;121(1-2):297-300. Available from: http://dx.doi.org/10.1016/j.jsbmb.2010.02.021
Go to original source...
Go to PubMed...
- Mahmoudi T. Genetic variation in the vitamin D receptor and polycystic ovary syndrome risk. Fertil Steril [Internet]. 2009;92(4):1381-3. Available from: http://dx.doi.org/10.1016/j.fertnstert.2009.05.002
Go to original source...
Go to PubMed...
- Teegarden D, Donkin SS. Vitamin D: Emerging new roles in insulin sensitivity. Nutr Res Rev. 2009;22(1):82-92.
Go to original source...
Go to PubMed...
- Muscogiuri G, Policola C, Prioletta A, et al. Low levels of 25(OH)D and insulin-resistance: 2 unrelated features or a cause-effect in PCOS? Clin Nutr [Internet]. 2012;31(4):476-80. Available from: http://dx.doi.org/10.1016/j.clnu.2011.12.010
Go to original source...
Go to PubMed...
- Selimoglu H, Duran C, Kiyici S, et al. The effect of vitamin D replacement therapy on insulin resistance and androgen levels in women with polycystic ovary syndrome. J Endocrinol Invest. 2010;33(4):234-8.
Go to original source...
Go to PubMed...
- Kotsa K, Yavropoulou MP, Anastasiou O, et al. Role of vitamin D treatment in glucose metabolism in polycystic ovary syndrome. Fertil Steril [Internet]. 2009;92(3):1053-8. Available from: http://dx.doi.org/10.1016/j.fertnstert.2008.07.1757
Go to original source...
Go to PubMed...
- Glintborg D, Andersen M, Hagen C, et al. Higher bone mineral density in Caucasian, hirsute patients of reproductive age. Positive correlation of testosterone levels with bone mineral density in hirsutism. Clin Endocrinol (Oxf). 2005;62(6):683-91.
Go to original source...
Go to PubMed...
- Thys-Jacobs S, Donovan D, Papadopoulos A, et al. Vitamin D and calcium dysregulation in the polycystic ovarian syndrome. Steroids. 1999;64(6):430-5.
Go to original source...
Go to PubMed...
- Lagunova Z, Porojnicu LC, Lindberg F, et al. The dependency of vitamin D status on body mass index, gender, age and season. Anticancer Res. 2009;29(9):3713-20.
Go to original source...
- Stumpf WE, Denny ME. Vitamin D (soltriol), light, and reproduction. Am J Obstet Gynecol [Internet]. 1989;161(5):1375-84. Available from: http://dx.doi.org/10.1016/0002-9378(89)90699-6
Go to original source...
Go to PubMed...
- Parikh G, Varadinova M, Suwandhi P, et al. Vitamin D regulates steroidogenesis and insulin-like growth factor binding protein-1 (IGFBP-1) production in human ovarian cells. Horm Metab Res. 2010;42(10):754-7.
Go to original source...
Go to PubMed...
- Sander VA, Hapon MB, Sícaro L, et al. Alterations of folliculogenesis in women with polycystic ovary syndrome. J Steroid Biochem Mol Biol. 2011;124(1-2):58-64.
Go to original source...
Go to PubMed...
- Menichini D, Facchinetti F. Effects of vitamin D supplementation in women with polycystic ovary syndrome: a review. Gynecol Endocrinol [Internet]. 2020;36(1):1-5. Available from: https://doi.org/10.1080/09513590.2019.1625881
Go to original source...
Go to PubMed...
- Irani M, Merhi Z. Role of vitamin D in ovarian physiology and its implication in reproduction: A systematic review. Fertil Steril [Internet]. 2014;102(2). Available from: http://dx.doi.org/10.1016/j.fertnstert.2014.04.046
Go to original source...
Go to PubMed...
- Zittermann A, Schleithoff SS, Koerfer R. Putting cardiovascular disease and vitamin D insufficiency into perspective. Br J Nutr. 2005;94(4):483-92.
Go to original source...
Go to PubMed...
- Merke J, Hofmann W, Goldschmidt D, et al. Demonstration of 1,25(OH)2 vitamin D3 receptors and actions in vascular smooth muscle cells In vitro. Calcif Tissue Int. 1987;41(2):112-4.
Go to original source...
Go to PubMed...
- Somjen D, Weisman Y, Kohen F, et al. 25-Hydroxyvitamin D3-1α-hydroxylase is expressed in human vascular smooth muscle cells and is upregulated by parathyroid hormone and estrogenic compounds. Circulation. 2005;111(13):1666-71.
Go to original source...
Go to PubMed...
- Merke J, Milde P, Lewicka S, et al. Identification and regulation of 1,25-dihydroxyvitamin D3 receptor activity and biosynthesis of 1,25-dihydroxyvitamin D3. Studies in cultured bovine aortic endothelial cells and human dermal capillaries. J Clin Invest. 1989;83(6):1903-15.
Go to original source...
Go to PubMed...
- Ching HL, Burke V, Stuckey BGA. Quality of life and psychological morbidity in women with polycystic ovary syndrome: Body mass index, age and the provision of patient information are significant modifiers. Clin Endocrinol (Oxf). 2007;66(3):373-9.
Go to original source...
Go to PubMed...
- Rasgon NL, Rao RC, Hwang S, et al. Depression in women with polycystic ovary syndrome: Clinical and biochemical correlates. J Affect Disord. 2003;74(3):299-304.
Go to original source...
Go to PubMed...
- Himelein MJ, Thatcher SS. Depression and body image among women with polycystic ovary syndrome. J Health Psychol. 2006;11(4):613-25.
Go to original source...
Go to PubMed...
- Murphy PK, Wagner CL. Vitamin D and Mood Disorders Among Women: An Integrative Review. J Midwifery Women's Heal. 2008;53(5):440-6.
Go to original source...
Go to PubMed...
- Jorde R, Sneve M, Figenschau Y, et al. Effects of vitamin D supplementation on symptoms of depression in overweight and obese subjects: Randomized double blind trial. J Intern Med. 2008;264(6):599-609.
Go to original source...
Go to PubMed...
- Zborowski J V, Talbott E, Cauley JA. POLYCYSTIC OVARY SYNDROME , ANDROGEN EXCESS , AND THE IMPACT ON BONE. 2001;28(1):135-51.
Go to original source...
Go to PubMed...
- Adami S, Zamberlan N, Castello R, et al. Effect of hyperandrogenism and menstrual cycle abnormalities on bone mass and bone turnover in young women. 1998;169-73.
Go to original source...
- Ferrannini E, Natali A, Bell P, et al. Insulin Resistance and Hypersecretion in Obesity. 1997;100(5):1166-73.
Go to original source...
Go to PubMed...
- Morin-papunen LC, Vauhkonen I, Koivunen RM, et al. Insulin sensitivity , insulin secretion , and metabolic and hormonal parameters in healthy women and women with polycystic ovarian syndrome. 2000;15(6):1266-74.
Go to original source...
Go to PubMed...
- Pasquali R, Gambineri A, Pagotto U. The impact of obesity on reproduction in women with polycystic ovary syndrome. BJOG An Int J Obstet Gynaecol. 2006;113(10):1148-59.
Go to original source...
Go to PubMed...
- Dunaif A, Segal KR, Futterweit W, et al. Profound Peripheral Insulin Resistance, Independent of Obesity, in Polycystic Ovary Syndrome. 1989;38(November 1988):1165-74.
Go to original source...
Go to PubMed...
- Zemel MB. Regulation of Adiposity and Obesity Risk By Dietary Calcium : Mechanisms and Implications. 2002;21(2):146-51.
Go to original source...
- Papers OOR, Holecki M, Zahorska-markiewicz B, et al. Osteoprotegerin - does it play a protective role in the pathogenesis of bone loss in obese perimenopausal women ? Czy osteoprotegeryna jest potencjalnym czynnikiem hamuj±cym ubytek masy kostnej oty³ych kobiet w wieku oko³omenopauzalnym ? 2007;58(1):7-10.
- Yanoff LB, Parikh SJ, Spitalnik A, et al. The prevalence of hypovitaminosis D and secondary hyperparathyroidism in obese Black Americans. 2006;523-9.
Go to original source...
- Scragg R, Jackson R, Holdaway IM, et al. Myocardial infarction is inversely associated with plasma 25-hydroxyvitamin D3 levels: A community-based study. Int J Epidemiol. 1990;19(3):559-63.
Go to original source...
Go to PubMed...
- Zella JB, Mccary LC, Deluca HF. Oral administration of 1,25-dihydroxyvitamin D 3 completely protects NOD mice from insulin-dependent diabetes mellitus. 2003;417:77-80.
Go to original source...
Go to PubMed...