MMSL 2022, 91(1):51-64 | DOI: 10.31482/mmsl.2021.031

USUTU VIRUS, ANOTHER EMERGING MOSQUITO-BORNE PATHOGEN IN CENTRAL EUROPEReview article

Jakub Vojtíšek ORCID...1,2, Radek Pečta1, Romana Kejíková ORCID...1, Zdeněk Hubálek ORCID...1, Silvie Šikutová ORCID...1, Ivo Rudolf ORCID...1,2*
1 Ústav biologie obratlovců AV ČR, v.v.i, Brno
2 Ústav experimentální biologie, Přírodovědecká fakulta, Masarykova univerzita, Brno

Usutu virus (USUV) je emergentní patogen přenášený komáry, taxonomicky náleží do rodu Flavivirus čeledi Flaviviridae. Tento původně africký arbovirus v roce 2001 způsobil hromadné hynutí ptactva v okolí Vídně a poté se rozšířil prakticky po celé střední, jižní a západní Evropě. USUV je primárně patogenní pro některé druhy pěvců, především kosy černé (Turdus merula), avšak patogenita byla prokázána i u řady jiných druhů, zejména z řádů dravců a sov. V posledních letech přibývá případů infekce u člověka. Cílem práce je podat ucelené informace o taxonomii viru, jeho genomu, životním cyklu včetně komářích vektorů a obratlovčích rezervoárů, endemickém výskytu v Africe i následném expanzivním šíření v Evropě, surveillanci v jednotlivých evropských státech, patogenitě viru pro obratlovce včetně popisu onemocnění, jež způsobuje, laboratorní diagnostice a dostupné léčbě.

Keywords: Usutu virus; USUV; flaviviry; ptáci; emergentní arboviry

Usutu virus (USUV) is an emerging mosquito-borne pathogen belonging to the genus Flavivirus and family Flaviviridae. This African arbovirus caused a large bird die-off near Vienna in 2001. Since then the virus spread in Central, Southern and Western Europe. USUV is a primarily pathogen of birds, highly pathogenic especially for blackbirds (Turdus merula), but with proven pathogenicity for other bird species, mainly from orders Accipitriformes and Strigiformes. However, the number of human cases of USUV infection has increased recently. In this review, we summarize the current knowledge on USUV taxonomy, its genome, transmission cycle involving mosquitoes as vectors and vertebrate hosts, endemic occurrence in Africa and expansive spread in Europe, surveillance in individual European countries, pathology and clinical manifestations in vertebrates, laboratory diagnosis of infection and available treatment.

Keywords: Usutu virus; USUV; flaviviruses; birds; emerging arboviruses

Received: September 4, 2021; Revised: September 30, 2021; Accepted: October 1, 2021; Prepublished online: November 8, 2021; Published: March 4, 2022  Show citation

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Vojtíšek, J., Pečta, R., Kejíková, R., Hubálek, Z., Šikutová, S., & Rudolf, I. (2022). USUTU VIRUS, ANOTHER EMERGING MOSQUITO-BORNE PATHOGEN IN CENTRAL EUROPE. MMSL, 91(1), 51-64. doi: 10.31482/mmsl.2021.031
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