MMSL 2022, 91(4):293-304 | DOI: 10.31482/mmsl.2022.005

A ROLE FOR INFLAMMATORY IL-6 IN THE DEVELOPMENT OF CORONARY ARTERY DISEASE:  A CASE CONTROL STUDY AT AL-QADISIYAH GOVERNORATE, IRAQOriginal article

Ajil A. Alzamily ORCID...*, Mohammed N. Al-Delfi ORCID..., Aqeel R Al-Barqaw
College of Medicine, University of AL-Qadisiyah; Iraq

Background: Disruption of the IL-6 axis can result in the beginning or progression of a variety of disease states, including cardiovascular diseases. Because of IL-6’s pathogenic function, pharmacologic manipulation of the IL-6 axis is a sensible therapeutic strategy; nevertheless, various expected, yet frequently overlooked, effects on tissues and organs other than blood vessels may also occur. The study’s goal is as follows: The purpose of this study is to see how inflammatory Interleukin-6 affects the development of coronary artery disease.

Materials and Methods: Serum IL-6 level was estimated using Elabscience® kits. A case-control study included 30 CAD patients, 30 positive controls (PC) [(have family history for CAD)], and  30 negative controls (NG) [they have no family history for CAD]. Ranged from 30 to 81 years old. Patients with acute or chronic illnesses such as liver disease, renal disease, thyroid function disorders, COVID-19, and autoimmune disease were excluded from the study. During the period from December 2020 to May 2021. Our study was included other factors such as ages, genders, smoking, family history, antihypertensive drugs or drugs for other diseases, body mass index (BMI)  which were assessed.

Results: The results of this study show increased levels of IL-6 in patients with CAD compared with the PC and NC These results showed a highly significant difference (p < 0.0001) in the concentrations compared with PC and NC.

Conclusions: IL-6 could be one of the prognostic signs of CAD.

Keywords: Coronary Artery Disease; IL-6; Inflammation; Cytokines

Received: December 12, 2021; Revised: January 16, 2022; Accepted: January 18, 2022; Prepublished online: February 11, 2022; Published: December 2, 2022  Show citation

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Alzamily, A.A., Al-Delfi, M.N., & Al-Barqaw, A.R. (2022). A ROLE FOR INFLAMMATORY IL-6 IN THE DEVELOPMENT OF CORONARY ARTERY DISEASE:  A CASE CONTROL STUDY AT AL-QADISIYAH GOVERNORATE, IRAQ. MMSL, 91(4), 293-304. doi: 10.31482/mmsl.2022.005
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