MMSL 2023, 92(3):280-286 | DOI: 10.31482/mmsl.2023.015

ASSESSMENT OF OXIDATIVE STRESS AND ANTIOXIDANT STATUS IN TYPE 1 DIABETES MELLITUSOriginal article

Fatimah Haitham Fathi ORCID...1*, Jehan A. Mohammad ORCID...2, Ammar A.Y. Almulathanon ORCID...3
1 Department of Clinical Laboratory Sciences, College of Pharmacy, University of Mosul, Mosul, Iraq
2 Department of Pharmacognosy and Medicinal Plants, College of Pharmacy, University of Mosul, Mosul, Iraq
3 Department of Pharmacology and Toxicology, College of Pharmacy, University of Mosul, Mosul, Iraq

Increased oxidative stress appears to be a risk factor for insulin resistance, dyslipidemia, β-cell dysfunction, impaired glucose tolerance, and, eventually, diabetes mellitus. The majority of research shows that oxidative stress plays a role in the etiology of diabetes through changes in enzymatic systems, lipid peroxidation, decreased levels of vitamin C, and reduced glutathione metabolism.

Objectives: the study was conducted to evaluate biomarkers of oxidative stress such as serum malondialdehyde (MDA), myeloperoxidase (MPO), catalase (CAT), vitamins (C, E), nitric oxide (NO), reduced glutathione (GSH) levels and a lipid profile in newly diagnosed type I diabetics (IDDM).

Methods: Patients are selected by simple randomization after professional diagnosis based on clinical examination and laboratory tests in a case-control study. This study included 24 newly diagnosed type I diabetics and 20 as a control group.

Results: Newly diagnosed IDDM patients showed significantly higher MDA, MPO, TC, LDL, TC, TG, and AIP than the control group. The diabetic group also showed a significant decrease in CAT, GSH, HDL, NO and vitamins (E and C) when compared to healthy subjects.

Conclusion: This study demonstrated that patients with type 1 diabetes have a disturbance in oxidant/antioxidant status and lipid profile.

Keywords: Antioxidants; Type 1 diabetes mellitus; Oxidative stress; Lipid; Vitamins

Received: December 26, 2022; Revised: April 12, 2023; Accepted: April 12, 2023; Prepublished online: April 14, 2023; Published: September 1, 2023  Show citation

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Fathi, F.H., Mohammad, J.A., & Almulathanon, A.A.Y. (2023). ASSESSMENT OF OXIDATIVE STRESS AND ANTIOXIDANT STATUS IN TYPE 1 DIABETES MELLITUS. MMSL, 92(3), 280-286. doi: 10.31482/mmsl.2023.015
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