MMSL 2024, 93(4):335-341 | DOI: 10.31482/mmsl.2023.040

A CLINICAL STUDY OF LIPOCALIN 2 AND ITS RELATION WITH OXIDATIVE AND ANTIOXIDATIVE FACTORS IN ARTHRITISOriginal article

Safa Rabea Saadon, Thikra Ali Allwsh ORCID...*
Department of Chemistry, Collage of Science, University of Mosul, 41002, Mosul, Iraq

Background: Lipocalin-2 (LCN2) is a protein that has been associated with skeletal muscle regeneration, but details regarding its role in Arthritis remain unclear. The aim of the current study was to investigate LCN2 levels of Arthritis patients and its relationship with oxidative and antioxidative factors.

Methods: The study includes (125) blood samples of persons aged 20–65 years were divided into a control group (apparently healthy) consisting of 55 samples [31female, 24 males] and a Patient group consisting of 70 samples [37female, 33 males] who were attending the bone diseases consultation unit at the Ibn Sina Teaching Hospital in Mosul, Iraq. Venous blood samples (10 ml) were collected after overnight fasting. To conduct Clinical analyses: Serum LCN2 level was determined by ELISA, also Malonaldehyde, glutathione, vitamin E, vitamin C, peroxy nitrite, peroxidase, and aryl esterase were estimated.

Results: The findings revealed a significant increase in the levels of LCN2 in Arthritis compared to the control group and there was a significant decrease in the concentration of vitamin C, glutathione, vitamin E and the activity of the arylesterase in serum of patients with arthritis compared with the control group. Also, a significant increase in the activity of peroxidase, concentration of peroxynitrite and malondialdehyde for patients than a control group.

Conclusion: These findings imply that LCN2 may play a substantial role in iron-related oxidative stress damage in arthritis. Thus a therapeutic candidate target for treatment.

Keywords: Lipocalin-2; oxidative stress; Arthritis; BMI

Received: September 3, 2023; Revised: October 25, 2023; Accepted: October 25, 2023; Prepublished online: December 19, 2023; Published: December 2, 2024  Show citation

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Saadon, S.R., & Allwsh, T.A. (2024). A CLINICAL STUDY OF LIPOCALIN 2 AND ITS RELATION WITH OXIDATIVE AND ANTIOXIDATIVE FACTORS IN ARTHRITIS. MMSL, 93(4), 335-341. doi: 10.31482/mmsl.2023.040
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