Background and Purpose: Different oak species (Quercus spp.) are widely distributed in Asia, Africa, Europe, and North America. The oak plant and its fruit hull have considerable antiinflammatory, antimicrobial, and antioxidant effects with important potential to be applied in wound healing products.

Methods: The systematic review of documents and manuscripts from clinical trials, and scientific societies has been carried out. The surveys of interest were indexed in “PubMed”, “Web of Science”, “SciFinder”, and “Elsevier”. As a research strategy to carry out this review, two reviewers were responsible for searching the publications. Relevant literature has been obtained using the keywords “antimicrobial activity”, “antioxidant activity”, “flavonoids”, “oak”, “oak fruit”, “phytochemicals”, “tannins”, and “natural components”. The selection criterion was to include research papers on the most important topics, using in vitro or in vivo studies.

Results: The most important Quercus species are Quercus infectoria, Quercus ilex, Quercus cerris, Quercus brantii, Quercus virgiliana, Quercus suber, Quercus rotundifolia, and Quercus robur. Important chemical com-ponents in lipophilic compounds are aliphatic alcohols such as octacosanol, hexacosanol, tetracosanol, and docosanol; fatty acids such as oleic acid and α linolenic acid; tannins such as castalagin, pedunculagin, and diagalloyl hexose; terpenoids such as cornin, agnuside, lamioside, and gibberellin A4 glucosylester; tocopherols such as α-tocopherol, β-tocopherol, and γ-tocopherol. The most important chemical constituents in its hydrophilic compounds are flavonoids, phenolic acids, tannin, amino acids, peptides, and analogues, carbohydrates and carbohydrate conjugates, and other phenolic compounds. Acorns are affordable and easily accessible raw material known in different cultures and regions which can be used in medicine, pharmacology, and food industry. Acorns are rich in many bioactive components with importance in food products with high health-promoting activities. Different parts of oak, especially its bark can be used as an antiseptic and hemostatic, which makes it appropriate to cure gastropathies, and toothache with beneficial activities as healing agents in burn.

Conclusions: The general conclusion is that different parts of oak can be used more widely as an important ingredient in drugs, supplements, and functional foods.

Keywords: antimicrobial activity; antioxidant activity; flavonoids; oak; oak fruit; phytochemicals; tannins