Central anticholinergic syndrome evoked by some incapacitating chemical agents from the family of anticholinergics is possible to treat with some reversible centrally active inhibitors of acetylcholinesterase. In this paper the view of anticholinergic incapacitating agents and their biological effects is summarize as well as a survey of inhibitors of acetylcholinesterase which may be used as antidotes against intoxication by incapacitating chemical agents. The position of 7-methoxytacrine as very effective and little toxic antidote is discussed.

Keywords: Incapacitating chemical agents; Biological effects; Acetylcholinesterase inhibitors; Antidotes