Vojenské Zdravotnické Listy, 1998 (vol. 67), Suppl.1
UNIVERSITY PARTNERSHIP PROJECT IN HEALTH SERVICES MANAGEMENT EDUCATION - DRIVING FORCE BEHIND THE DEVELOPMENT OF EDUCATIONAL NETWORK IN THE CZECH REPUBLIC
Roman Prymula, Jiří Pavlíček, Jiří Beran
MMSL 1998, 67(S1):1-5 
The Czech health care system has been completely redesigned within the last 7-year period. There are many issues involved, which should be solved in the following months and years. One of the most serious is the lack of professional managers with a good knowledge of managerial science, practical skills and a thorough understanding of economics, particularly middle level managers. To help fill this gap, two partnerships between US and Czech universities have been established. Attention has been focused mainly on curriculum development and finalisation, information resources, and faculty development. In spite of the very short time period (less...
THE CORRELATION OF THE PRESENCE OF HYALINE MEMBRANES IN RADIATION PNEUMONITIS TO TIME AND RADIATION DOSE
Jan Österreicher, Jiřina Vávrová, Jan Nožička, Pavel Petýrek, Jiří Knížek
MMSL 1998, 67(S1):5-8
This study monitors the presence of hyaline membranes in (C57BI/6xDBA/2)F1 mice irradiated locally with gamma radiation of 60Co in the area of the thorax with absorbed doses of 14, 16 and 18 Gy and in a time interval of 18, 24, 30 and 36 weeks after the irradiation of the histologically examined mice. Hyaline membranes were not noted in mice irradiated with the lowest dose of 14 Gy of gamma radiation nor in all the animals examined 18 weeks after the irradiation. We can see from the results that hyaline membranes are observed in the lungs only after higher doses of radiation and in time intervals of 24, 30 and 36 weeks after the irradiation...
THE CORRELATION OF INFILTRATION OF NEUTROPHIL GRANULOCYTES AFTER LOCAL IRRADIATION OF THE THORAX TO TIME AND RADIATION DOSE
Jan Österreicher, Jiřina Vávrová, Jan Nožička, Pavel Petýrek, Jiří Knížek
MMSL 1998, 67(S1):8-11
This study monitors the presence of neutrophil granulocytes in the lungs in (C57BI/6xDBA/2)F1 mice irradiated locally in the area of the thorax with absorbed doses of 14, 16 and 18 Gy of gamma radiation in a time interval of 18, 24, 30 and 36 weeks after irradiation Of histologically examined animals. During the histologic examination, an increased amount of neutrophil granulocytes was noted 24 weeks after the irradiation when the extent of inflammatory infiltration of irradiated lungs reached maximum values. In other time intervals, a decreasing trend in the average number of neutrophil granulocytes in the viewing field was found. The values...
THE REACTIVATORS OF ISOPROPYLMETHYL-PHOSPHONYLATED ACETYLCHOLINESTERASE DERIVED FROM 2-HYDROXYIMINOMETHYLPYRIDINE
Jiří Patočka, Jiří Cabal, Jiří Bielavský, Josef Vachek
MMSL 1998, 67(S1):11-13
Four new 4-substituted pyridinium-2-aldoxime methoiodides were prepared and their physico-chemical properties were estimated, including their pKa values. Compounds were tested as reactivators of acetylcholinesterase inhibited by isopropyl-methylphosphonofluoridate in vitro. Their acute toxicities were estimated in mice after i.m. administration. Results show that these compounds are less toxic than 2—pyridinium-aldoxime methiodide (2-PAM) alone, but only one compound was better reactivator than 2-PAM.
THE EFFICACY OF 7-METHOXYTACRINE IN THE TREATMENT OF CENTRAL ANTICHOLINERGIC SYNDROME CAUSED BY SOME INCAPACITATING CHEMICAL AGENTS
Jiří Patočka, Josef Fusek
MMSL 1998, 67(S1):14-19
Central anticholinergic syndrome evoked by some incapacitating chemical agents from the family of anticholinergics is possible to treat with some reversible centrally active inhibitors of acetylcholinesterase. In this paper the view of anticholinergic incapacitating agents and their biological effects is summarize as well as a survey of inhibitors of acetylcholinesterase which may be used as antidotes against intoxication by incapacitating chemical agents. The position of 7-methoxytacrine as very effective and little toxic antidote is discussed.
THE INFLUENCE OF ISOLATED SOMAN-INDUCED ERYTHROCYTE ACETYLCHOLINESTERASE INHIBITION ON BASIC PHYSIOLOGICAL FUNCTIONS IN RABBITS
Jiří Kassa, Jiří Bajgar, Josef Fusek
MMSL 1998, 67(S1):19-23
The influence of isolated soman-induced inhibition of erythrocyte acetylcholinesterase on the basic physiological functions (respiration and circulation) was evaluated in a rabbit model with on-line monitoring of respiratory and circulatory parameters. Following 24h incubation of rabbit erythrocytes with soman (10-3 M) in vitro, the erythrocytes were added into plasma and injected to intact anaesthetized rabbit. The respiratory and circulatory parameters were monitored till 120 min following the end of blood-transfusion. At the end of experiments, the blood and various organs were removed to measure cholinesterase activities.No changes...
TOXICOLOGY OF ω-FLUOROCARBOXYLIC ACIDS
Jiří Patočka, Jiří Cabal
MMSL 1998, 67(S1):23-28
At this time we know thousands of organofluorine compounds and many of them are very toxic for humans (1). Mainly fluoroacetic acid and many other alifatic monofluoro compounds satisfied criteria of reliable poisons (2) and several these compounds were examined during the last war for possible use as chemical warfare agents (3-5). Author of this article hopes that more widespread knowledge of these very dangerous compounds may act as a deterrent to their illegal use and that concern may be stimulated in the search for more satisfactory methods of medical treatment.
SUBSTITUTED PYRIDINIUM DERIVATIVES AS INHIBITORS OF ACETYLCHOLINESTERASE
Kateřina Ševčíková, František Hampl, František Liška, Jiří Cabal, Jiří Patočka
MMSL 1998, 67(S1):28-31
The interaction of twenty-Six different I 2-, 3-, and 4- substituted N-methylpyridinium iodides withacetylcholinesterase (A ChE) was investigated in vitro experiments. All compounds involved in this study werefound to be competitive AChE inhibitors with Kdiss values ranging from 5.5 to 130 ,μM.