The influence of isolated soman-induced inhibition of erythrocyte acetylcholinesterase on the basic physiological functions (respiration and circulation) was evaluated in a rabbit model with on-line monitoring of respiratory and circulatory parameters. Following 24h incubation of rabbit erythrocytes with soman (10^-3 M) in vitro, the erythrocytes were added into plasma and injected to intact anaesthetized rabbit. The respiratory and circulatory parameters were monitored till 120 min following the end of blood-transfusion. At the end of experiments, the blood and various organs were removed to measure cholinesterase activities.
No changes in monitored respiratory and circulatory parameters as well as no significant changes in cholinesterase activities with the exception of erythrocyte acetylcholinesterase were observed in comparison with controls. These data suggest that isolated significant decrease in erythrocyte acetylcholinesterase has not any influence on the basic physiological functions in rabbits.

Keywords: Soman; Acetylcholinesterase; Transfusion; Respiration; Circulation; Rabbit