MMSL 1998, 67(S1):28-31
SUBSTITUTED PYRIDINIUM DERIVATIVES AS INHIBITORS OF ACETYLCHOLINESTERASE
- 1 Institute of Chemical Technology, Prague
- 2 Purkyně Military Medical Academy, Hradec Králové
The interaction of twenty-Six different I 2-, 3-, and 4- substituted N-methylpyridinium iodides with
acetylcholinesterase (A ChE) was investigated in vitro experiments. All compounds involved in this study were
found to be competitive AChE inhibitors with Kdiss values ranging from 5.5 to 130 ,μM.
Keywords: Acetylcholinesterase; Inhibition; Pyridinium salts
Published: September 1, 1998 Show citation
