The etiology of Alzheimer’s disease, neurodegenerative disorder with impairment of cognitive functions and the loss of memory, is unknown. The deficit of the brain acetylcholine and cholinergic neurotransmission insufficence in Alzheimer’s patient is commonly accepted now. The key role of acetylcholinesterase, an important enzyme of cholinergic transmission in the etiology as well as in the therapy of Alzheimer’s disease is discussed in this paper.

Keywords: Alzheimer’s disease; Acetylcholinesterase; Nervous system; Etiopathology