Vojenské Zdravotnické Listy, 1998 (vol. 67), Suppl.2
CHOLINESTERASES AND THEIR POSSIBLE INFLUENCING
Jiří Bajgar
MMSL 1998, 67(S2):1-6 
Acetylcholinesterase and butyrylcholinesterase is characterized according to their properties and possible influencing of their activities by inhibitors and other factors.
ACETYLCHOLINESTERASE: THE KEY TO UNDERSTANDING ETIOLOGY AND THERAPY OF ALZHEIMER’S DISEASE ?
Anna Strunecká
MMSL 1998, 67(S2):7-11
The etiology of Alzheimer’s disease, neurodegenerative disorder with impairment of cognitive functions and the loss of memory, is unknown. The deficit of the brain acetylcholine and cholinergic neurotransmission insufficence in Alzheimer’s patient is commonly accepted now. The key role of acetylcholinesterase, an important enzyme of cholinergic transmission in the etiology as well as in the therapy of Alzheimer’s disease is discussed in this paper.
SOME CHARACTERISTICS OF SOMAN, SARIN AND VX POISONING
Jiří Bajgar
MMSL 1998, 67(S2):12-15
Effects of sarin, soman and VX were described and discussed. The trigger mechanism of their action is inhibition of cholinesterases followed by non-specific changes. However, changes in cholinesterase molecular forms are of interest and they play an important role in mechanism of action of nerve agents, too.
NON-SPECIFIC EFFECTS OF ORGANOPHOSPHORUS INHIBITORS OF CHOLINESTERASES
Jiří Kassa
MMSL 1998, 67(S2):15-19
This paper proposes the main aspects of the pathogenesis of acute poisoning with organophosphorus inhibitors of cholinesterases and describes non-specific effects of these toxic substantes such as the activation of multiple non-Cholinergic neurotransmitter systems in the central nervous system, the alteration of energetic metabolism, stressogenic effects, mutagenic effects, immune effects, the alteration of water and mineral metabolism, hepatotoxic effects, membrane effects as well as haematological effects. One of the most important non-specific effects produced by organophosphorus agents is the activation of multiple noncholinergic neurotransmitter...
GALANTHAMINE, A NATURAL INHIBITOR OF CHOLINESTERASES: DETERMINATION BY CAPILLARY ZONE ELECTROPHORESIS
Lenka Pokorná, Alma Revilla, Josef Havel, Jiří Patočka
MMSL 1998, 67(S2):19-22
The research to find better medicaments against Alzheimer’s disease is going on continuos. New drugs are under different levels of study. Galanthamine, an acetylcholinesterase inhibitor, is in phase III (clinical trials) in Austria. In this communication, the results of its determination in biological fluids and pharmaceutical preparations using capillary zone electrophoresis are presented.
NATURAL NEUROTOXINS WITH TARGETING TO CHOLINERGIC NERVOUS SYSTEM (CHOLINOTOXINS)
Jiří Patočka
MMSL 1998, 67(S2):22-31
Cholinergic nervous system plays an important role in many physiological and behavioral functions in all animals. The activity of central and peripheral nervous system depends on the production and fate of acetylcholine and all compounds influenced its biosynthesis, storage, release, hydrolysis, and interactions with different subtypes of acetylcholine both muscarinic and nicotinic receptors. Many natural neurotoxins also interact with different parts of cholinergic nervous system and these compounds are the aim of this review.
EFFECTS OF NEUROTOXINS ON SOME BEHAVIORAL MANIFESTATIONS
Marie Koupilová, Josef Herink
MMSL 1998, 67(S2):31-38
Behavioral tests were employed in the study of central effects of the selected neurotoxins mescaline, FAZ-4 and DSP-4 at stereotactical administration into three cerebral structures (ventriculus cerebri Iateralis, ncl. basalis Meynerti and nc. septi medialis).The results have confirmed the assumed negative action with cholinergic and monoaminergic dysfunctions, manifested by a disorder in the recall from animal memory immediately after their administration and with latency of several weeks. Different effects of individual neurotoxins on animal behaviour were observed also in dependence on the structure of administration.