We monitored the number of neutrophil granulocytes and the thickness of alveolar Septa in (057Bl/6xDBA/2)F1 mice 168 days after γ- irradiation in the area of the Iungs with a dose of 16 Gy (LD₅) and 180 days after irradiation with a dose of 18 Gy (LD₅₀). The laboratory animals were administered Pentoxifyline (3,5 and 35 mg/kg), Dexamethasone (1 and 10 mg/kg) and a combination of Pentoxifyline (35 mg/kg) and Dexamethasone (10 mg/kg) twice a week. In the animals examined 168 days after irradiation with a dose of 16 Gy, a significant decrease in the number of neutrophil granulocytes and a decrease in the thickness of alveolar septa were found in all the treated animals. The largest effect was seen in a combination of PTX and DXM. In the individuals examined 180 days after irradiation with a dose of 18 Gy, a similar trend was found. The largest effect was seen in DXM (10 mg/kg) and in a combination of DXM and PTX....

Keywords: y-Irradiation; Lung; Pentoxifylline; Dexamethasone (DXM); Image analysis